Results 11 to 20 of about 28,100,614 (312)
Combination treatment of neuropathic pain: Danish expert recommendations based on a Delphi process
Journal of Pain Research, 2017 Background Current Danish treatment algorithms for pharmacological treatment of neuropathic pain (NeP) are tricyclic antidepressants (TCA), gabapentin and pregabalin as first-line treatment for the most common NeP conditions.
J. V. Holbech +5 more
semanticscholar +2 more sources
Anti-inflammatory activity of berberine in non-alcoholic fatty liver disease via the Angptl2 pathway
BMC Immunology, 2020 Background Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease worldwide. Recent studies have shown that the Angptl2 pathway mediated hepatic inflammatory response plays an important role in the progression of nonalcoholic ...
Zengsheng Lu +4 more
doaj +1 more source
Cells, 2022 Ballooning degeneration of hepatocytes is a major distinguishing histological feature of non-alcoholic steatosis (NASH) progression that can lead to cirrhosis and hepatocellular carcinoma (HCC).
K. Murakami +14 more
semanticscholar +1 more source
Pharmaceuticals, 2022 NK/T-cell lymphoma (NKTCL) and γδ T-cell non-Hodgkin lymphomas (γδ T-NHL) are highly aggressive lymphomas that lack rationally designed therapies and rely on repurposed chemotherapeutics from other hematological cancers. Histone deacetylases (HDACs) have
Harsimran Kaur Garcha +16 more
doaj +1 more source
Journal of Allergy and Clinical Immunology, 2022 Background: Thymic stromal lymphopoietin (TSLP) has been shown to play a central role in the initiation and persistence of allergic responses. Objective: We evaluated whether tezepelumab, a human monoclonal anti-TSLP antibody, improved the efficacy of ...
J. Corren +21 more
semanticscholar +1 more source
Preclinical and clinical developments for combination treatment of influenza
PLoS Pathogens, 2022 Antiviral drugs are an important measure of control for influenza in the population, particularly for those that are severely ill or hospitalised. The neuraminidase inhibitor (NAI) class of drugs, including oseltamivir, have been the standard of care ...
Paulina Koszalka +2 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2022 The anticancer effects of ruxolitinib and calcitriol against breast cancer were reported previously. However, the effect of ruxolitinib and calcitriol combination treatment on various molecular subtypes of breast cancer remains unexplored. In this study,
J. Schneider, Y. Jeon, Y. Suh, S. Lim
semanticscholar +1 more source
Biology, 2023 There is an evolving landscape of systemic combination regimens for patients with advanced well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
Leonidas N. Diamantopoulos +4 more
doaj +1 more source
iScience, 2021 Antiviral treatments targeting the coronavirus disease 2019 are urgently required. We screened a panel of already approved drugs in a cell culture model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and identified two new agents having ...
Hirofumi Ohashi +29 more
semanticscholar +1 more source
PI3Kβ inhibition enhances ALK‐inhibitor sensitivity in ALK‐rearranged lung cancer
Molecular Oncology, 2023 Treatment with anaplastic lymphoma kinase (ALK) inhibitors significantly improves outcome for non‐small‐cell lung cancer (NSCLC) patients with ALK‐rearranged tumors. However, clinical resistance typically develops over time and, in the majority of cases,
Sarang S. Talwelkar +12 more
doaj +1 more source