Results 1 to 10 of about 28,100,614 (312)

Influence of immune checkpoint inhibitor target and timing on combination treatment with antibody-based β-emitting targeted radionuclide therapy across tumor immunogenicity profiles [PDF]

Frontiers in Immunology
IntroductionTargeted radionuclide therapy (TRT) and immune checkpoint inhibition (ICI) could be a highly effective combination treatment due to potential synergistic effects.
Simone C. Kleinendorst, Egbert Oosterwijk, Mark Konijnenberg, Mark Konijnenberg, Milou Boswinkel, Manon Gloudemans, Sylvia T.M. Wenker, Stijn Muselaers, Peter Mulders, Lyndsey Maffa, Michael F. O’Hara, Michael P. Wheatcroft, Kwame Twumasi-Boateng, Sandra Heskamp   +13 more
doaj   +2 more sources

A stretchable wireless wearable bioelectronic system for multiplexed monitoring and combination treatment of infected chronic wounds

Science Advances, 2023
Chronic nonhealing wounds are one of the major and rapidly growing clinical complications all over the world. Current therapies frequently require emergent surgical interventions, while abuse and misapplication of therapeutic drugs often lead to an ...
Ehsan Shirzaei Sani, Changhao Xu, Canran Wang, Yu Song, Jihong Min, J. Tu, S. Solomon, Jiahong Li, Jaminelli Banks, D. Armstrong, Wei Gao   +10 more
semanticscholar   +1 more source

Estimated Lifetime Cardiovascular, Kidney, and Mortality Benefits of Combination Treatment With SGLT2 Inhibitors, GLP-1 Receptor Agonists, and Nonsteroidal MRA Compared With Conventional Care in Patients With Type 2 Diabetes and Albuminuria

Circulation, 2023
BACKGROUND: Sodium glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and the nonsteroidal mineralocorticoid receptor antagonist (ns-MRA) finerenone all individually reduce cardiovascular, kidney, and ...
B. Neuen, H. Heerspink, P. Vart, B. Claggett, Robert A. Fletcher, C. Arnott, Juliana de Oliveira Costa, M. Falster, S. Pearson, K. Mahaffey, B. Neal, R. Agarwal, G. Bakris, V. Perkovic, Scott D. Solomon, M. Vaduganathan   +15 more
semanticscholar   +1 more source

When Molecular-Targeted Agents Meet Immunotherapy: The Opportunities for Soft Tissue Sarcoma [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
Soft tissue sarcomas (STS) account for less than 1% of adult cancers with a median overall survival of 12 months in the metastatic setting. Although chemotherapy remains the standard of treatment for advanced disease, molecular targeted agents (MTAs) and
Vanina E. Wainsztein, Tom W. Chen
doaj   +1 more source

A preliminary study on drug switching strategy for second-line therapy after combination treatment of tyrosine kinase inhibitors and immune checkpoint inhibitors for unresectable hepatocellular carcinoma

Frontiers in Pharmacology, 2022
Background: Combination treatment with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) has been widely used in patients with unresectable hepatocellular carcinoma (uHCC).
Renguo Guan, Renguo Guan, Renguo Guan, Chengyou Yu, Chengyou Yu, Chengyou Yu, Shaohua Li, Shaohua Li, Shaohua Li, Jie Mei, Jie Mei, Jie Mei, Wei Wei, Wei Wei, Wei Wei, Rongping Guo, Rongping Guo, Rongping Guo   +17 more
doaj   +1 more source

Combination Treatment Strategies to Overcome PARP Inhibitor Resistance

Biomolecules, 2023
Poly(ADP-ribose) polymerase (PARP) enzymes have been shown to be essential for DNA repair pathways, including homologous recombination repair (HRR). Cancers with HRR defects (e.g., BRCA1 and BRCA2 mutations) are targets for PARP inhibitors (PARPis) based
Y. Soung, Jun Chung
semanticscholar   +1 more source

Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT

Health Technology Assessment, 2022
Background: The mainstay of treatment for diabetic peripheral neuropathic pain is pharmacotherapy, but the current National Institute for Health and Care Excellence guideline is not based on robust evidence, as the treatments and their combinations have ...
Solomon Tesfaye, Gordon Sloan, Jennifer Petrie, David White, Mike Bradburn, Tracey Young, Satyan Rajbhandari, Sanjeev Sharma, Gerry Rayman, Ravikanth Gouni, Uazman Alam, Steven A Julious, Cindy Cooper, Amanda Loban, Katie Sutherland, Rachel Glover, Simon Waterhouse, Emily Turton, Michelle Horspool, Rajiv Gandhi, Deirdre Maguire, Edward Jude, Syed Haris Ahmed, Prashanth Vas, Christian Hariman, Claire McDougall, Marion Devers, Vasileios Tsatlidis, Martin Johnson, Didier Bouhassira, David L Bennett, Dinesh Selvarajah   +31 more
doaj   +1 more source

Combination treatment of docetaxel with caffeic acid phenethyl ester suppresses the survival and the proliferation of docetaxel-resistant prostate cancer cells via induction of apoptosis and metabolism interference

Journal of Biomedical Sciences, 2022
Docetaxel has been approved by USFDA as a first-line treatment for castration-resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy along with docetaxel result in superior survival, lower serum prostate specific ...
Yu-Ke Fu, Bi-Juan Wang, Jen-Chih Tseng, Shi Huang, Ching-Yu Lin, Ying-Yu Kuo, T. Hour, Chih-Pin Chuu   +7 more
semanticscholar   +1 more source

NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice

eLife, 2023
Transplantation of neural stem cells (NSCs) has been proved to promote functional rehabilitation of brain lesions including ischemic stroke. However, the therapeutic effects of NSC transplantation are limited by the low survival and differentiation rates
Ruolin Zhang, Weibing Mao, Lumeng Niu, Wendai Bao, Yiqi Wang, Ying Wang, Yasha Zhu, Zhihao Yang, Jincao Chen, Jiawen Dong, Meng Cai, Zilong Yuan, Haikun Song, Guangqiang Li, Min Zhang, Nanxiang Xiong, Jun Wei, Zhiqiang Dong   +17 more
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Synergistic Killing and Re-Sensitization of Pseudomonas aeruginosa to Antibiotics by Phage-Antibiotic Combination Treatment

Pharmaceuticals, 2021
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a serious health threat. Bacteriophage–antibiotic combination therapy is a promising candidate for combating these infections. A 5-phage P.
E. Engeman, Helen R. Freyberger, B. Corey, A. M. Ward, Yunxiu He, M. Nikolich, A. Filippov, Stuart D. Tyner, Anna C. Jacobs   +8 more
semanticscholar   +1 more source