Results 211 to 220 of about 1,152,460 (369)

Papers on combinatorial chemistry or solid-phase synthesis from other journals - September 2000

, 2000

openalex   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Evolution Driven Microscale Combinatorial Chemistry in Intracellular Mimicking Droplets to Engineer Thermostable RNA for Cellular Imaging. [PDF]

Small
Kinghorn AB, Guo W, Wang L, Tang MYH, Wang F, Shiu SC, Lau KK, Jinata C, Poonam AD, Shum HC, Tanner JA.   +10 more
europepmc   +1 more source

Papers on combinatorial chemistry or solid-phase synthesis from other journals - April 2000

, 2000

openalex   +1 more source

Anion templates in synthesis and dynamic combinatorial libraries

, 2008
AV Eliseev, B Hasenknopf, B Hasenknopf, C Reuter, C Reuter, C Seel, CS Campos-Fernandez, CS Campos-Fernandez, D Meshcheryakov, DH Busch, DK Chand, EA Katayev, EA Katayev, EA Katayev, GA Melson, GM Hubner, H Amouri, H Amouri, J-M Lehn, J-M Lehn, J-M Lehn, JA Wisner, JS Fleming, M Bru, M Roitzsch, MC Thompson, MCT Fyfe, MD Lankshear, MD Lankshear, MR Sambrook, N Gimeno, P Diaz, PT Corbett, R Vilar, R Vilar, R Vilar, RL Paul, S Anderson, S Otto, S Otto, S Otto, SJ Rowan, SJ Rowan   +42 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Pioneering integration of combinatorial chemistry and machine learning to accelerate the development of tailored LNPs for mRNA delivery. [PDF]

Acta Pharm Sin B
He X, Wang P, Qing L, Song X.
europepmc   +1 more source

Papers on combinatorial chemistry or solid-phase synthesis from other journals - February 2000

, 2000

openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Special Issue: Selected Papers from the Second Eurasian Meeting on Heterocyclic Chemistry: Heterocycles in Organic and Combinatorial Chemistry [PDF]

, 2003
Eugene V. Babaev
openalex   +1 more source