Results 231 to 240 of about 1,090,432 (279)

Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures

Chemical Society Reviews, 2014
Reversible covalent bond formation under thermodynamic control adds reactivity to self-assembled supramolecular systems, and is therefore an ideal tool to assess complexity of chemical and biological systems. Dynamic combinatorial/covalent chemistry (DCC)
Andreas Herrmann
exaly   +2 more sources

Dynamic Combinatorial Chemistry in Chemical Catalysis

Israel Journal of Chemistry, 2013
Despite the progress in the field of dynamic combinatorial chemistry (DCC), dynamic combinatorial catalysis has received considerably less attention. Some first studies, however, have provided proof of principle and demonstrated that DCC-based approaches
Joost N H Reek, Paweł Dydio, Pierre-alain R Breuil   +2 more
exaly   +2 more sources

Diffusion NMR Spectroscopy in Supramolecular and Combinatorial Chemistry: An Old Parameter?New Insights

Angewandte Chemie - International Edition, 2005
Intermolecular interactions in solution play an important role in molecular recognition, which lies at the heart of supramolecular and combinatorial chemistry.
Yoram Cohen, Liat Avram, Hongmei Yang
exaly   +2 more sources

Dynamic Generation of G-Quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nanoplatform.

Journal of Medicinal Chemistry, 2018
Dynamic combinatorial chemistry (DCC) has emerged as a promising strategy for template-driven selection of high-affinity ligands for biological targets from equilibrating combinatorial libraries.
S. Jana, Deepanjan Panda, P. Saha, G. Pantoș, J. Dash   +4 more
semanticscholar   +1 more source

Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry.

ACS Combinatorial Science, 2018
Solid-phase organic synthesis is a powerful tool in the synthesis of small organic molecules and building of libraries of compounds for drug discovery.
Aizhan Abdildinova, Y. Gong
semanticscholar   +1 more source

Application of Pictet-Spengler Reaction to Indole-Based Alkaloids Containing Tetrahydro-β-carboline Scaffold in Combinatorial Chemistry.

ACS Combinatorial Science, 2017
Indole-based alkaloids are well-known in the literature for their diverse biological properties. Polysubstituted optically active tetrahydro-β-carboline derivatives functionalized on C-1 position are the common structural motif in most of the indole ...
R. N. Rao, Barnali Maiti, K. Chanda
semanticscholar   +1 more source

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases.

Journal of combinatorial chemistry, 1999
The discovery of various protein/receptor targets from genomic research is expanding rapidly. Along with the automation of organic synthesis and biochemical screening, this is bringing a major change in the whole field of drug discovery research.
A. Ghose, and Vellarkad N. Viswanadhan, J. Wendoloski   +2 more
semanticscholar   +1 more source

Dynamic combinatorial chemistry on a monolayer protected gold nanoparticle.

Chemical Communications, 2015
Here, we show that the addition of Hg(2+) or Ag(+) metal ions to a dynamic system composed of monolayer protected gold nanoparticles (Au NPs) and a mixture of four nucleotides (dGMP, dAMP, TMP, and dCMP) leads to the self-selection of TMP or dGMP ...

semanticscholar   +1 more source

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Angewandte Chemie, 2014
Structure-based design (SBD) can be used for the design and/or optimization of new inhibitors for a biological target. Whereas de novo SBD is rarely used, most reports on SBD are dealing with the optimization of an initial hit.
M. Mondal, N. Radeva, H. Köster, A. Park, C. Potamitis, M. Zervou, G. Klebe, A. Hirsch   +7 more
semanticscholar   +1 more source