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Solid‐Phase Synthesis of Lipidated Peptides [PDF]
Chemistry – A European Journal, 2005 AbstractA new flexible and efficient methodology for the solid‐phase synthesis of lipidated peptides has been developed. The approach is based on the use of previously synthesized building blocks and overcomes the limitations of previously reported methods, since long doubly lipidated peptides can be synthesized by using this route. Furthermore, it was
Lumbierres, M. +5 more
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Frontiers in Chemistry, 2020 Peptoids hold status as peptide-mimetics with versatile biological applications due to their proteolytic stability and structural diversity. Among those that have been studied in different biological systems, are peptoids with dominant balanced ...
Abdullah Lone +5 more
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Synthesis of Chlorotoxin by Native Chemical Ligation
Journal of the Turkish Chemical Society, Section A: Chemistry, 2018 Chlorotoxin (CLTX) is a neurotoxin found in the venom of the Israeli scorpion, Leirius quinquestriatus. It contains 36-amino acids with four disulfide bonds and inhibits low-conductance chloride channels.
Ulvi Karaca +2 more
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Parallel solid-phase synthesis of diaryltriazoles
Beilstein Journal of Organic Chemistry, 2012 A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a ...
Matthias Wrobel +2 more
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Molecules, 2011 The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli +7 more
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Total wash elimination for solid phase peptide synthesis
Nature Communications, 2023 We present a process for solid phase peptide synthesis (SPPS) that completely eliminates all solvent intensive washing steps during each amino acid addition cycle.
Jonathan M. Collins +6 more
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Solid‐Phase Synthesis of Oligosaccharides
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Diederichsen, Ulf, Wagner, Thomas
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New Solid Phase Synthesis of Distamycin Analogues
Molecules, 2011 A novel and straightforward solid phase synthesis of distamycin analogues containing benzene units has been developed.
Drozdowska Danuta
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Photolabile Linkers for Solid-Phase Synthesis [PDF]
ACS Combinatorial Science, 2018 Photolabile linkers are the subjects of intense research because they allow the release of the target molecule simply by irradiation. Photochemical release of synthesis products is often facilitated without additional reagents under mild reaction conditions, which may even be environmentally friendly and appealing in the context of greener chemistry ...
Remi J. T. Mikkelsen +4 more
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Solid-Phase Synthesis of ?-Oligopeptides
CHIMIA, 1997 Fmoc-N-Protected ?-amino acids of (S)-configuration bearing the side chains of Ala, Val, Leu, and Phe in the 3- and 2-position have been prepared. Manual solid-phase synthesis (ortho-chlorotrityl-chloride resin) of the ?-heptapeptides H-?3-HVal-?
Gilles Guichard, Dieter Seebach
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