Results 261 to 270 of about 1,058,395 (336)

Combinatorial chemistry of hydantoins

Bioorganic & Medicinal Chemistry Letters, 1998
Access to combinatorial chemistry of hydantoins is provided by convenient and versatile methods for the solid phase synthesis of libraries of 3,5-, 1,3- and 1,3,5-substituted hydantoins. The preparation of trisubstituted hydantoins features a Mitsunobu reaction for introduction of the substituent on N-1.
Astrid Boeijen, John A. W. Kruijtzer, Rob M. J. Liskamp   +2 more
openaire   +4 more sources

Dynamic combinatorial chemistry

Drug Discovery Today, 2002
A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal. Dynamic combinatorial chemistry has the potential to achieve exactly this. In this review, we will highlight the unique features that distinguish dynamic combinatorial chemistry from traditional ...
Jeremy K. M. Sanders, Ricardo L. E. Furlan, Sijbren Otto   +2 more
openaire   +3 more sources

Dynamic Generation of G-Quadruplex DNA Ligands by Target-Guided Combinatorial Chemistry on a Magnetic Nanoplatform.

Journal of Medicinal Chemistry, 2018
Dynamic combinatorial chemistry (DCC) has emerged as a promising strategy for template-driven selection of high-affinity ligands for biological targets from equilibrating combinatorial libraries.
S. Jana, Deepanjan Panda, P. Saha, G. Pantoș, J. Dash   +4 more
semanticscholar   +1 more source

Steroids and Combinatorial Chemistry

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Liviu C. Ciobanu, Donald Poirier, Martin R. Tremblay, René Maltais   +3 more
openaire   +4 more sources

Current Parallel Solid-Phase Synthesis of Drug-like Oxadiazole and Thiadiazole Derivatives for Combinatorial Chemistry.

ACS Combinatorial Science, 2018
Solid-phase organic synthesis is a powerful tool in the synthesis of small organic molecules and building of libraries of compounds for drug discovery.
Aizhan Abdildinova, Y. Gong
semanticscholar   +1 more source

Basics of Combinatorial Chemistry

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Alain Wagner, Cécile Vanier
openaire   +2 more sources

Application of Pictet-Spengler Reaction to Indole-Based Alkaloids Containing Tetrahydro-β-carboline Scaffold in Combinatorial Chemistry.

ACS Combinatorial Science, 2017
Indole-based alkaloids are well-known in the literature for their diverse biological properties. Polysubstituted optically active tetrahydro-β-carboline derivatives functionalized on C-1 position are the common structural motif in most of the indole ...
R. N. Rao, Barnali Maiti, K. Chanda
semanticscholar   +1 more source

Overview of Combinatorial Chemistry

Current Protocols in Pharmacology, 2000
AbstractThis unit provides an overview of combinatorial chemistry, including the design and construction of combinatorial libraries for drug discovery. Strategies and resources for library synthesis are summarized, and examples of combinatorial libraries are given.
Stephen L. Crooks, Leslie J. Charles
openaire   +3 more sources

Nanotiterplates for combinatorial chemistry

Reviews in Molecular Biotechnology, 2001
Miniaturization has grown to be a driving force in modern chemical and biochemical laboratories. Combinatorial explosion demands for new pathways for the synthesis and screening of new substances which can act as leads in drug discovery. Highly parallelized automata that can handle the smallest amounts of substances are needed. However, the development
Andreas Schober, Günter Mayer, J. Michael Köhler   +2 more
openaire   +3 more sources

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases.

Journal of combinatorial chemistry, 1999
The discovery of various protein/receptor targets from genomic research is expanding rapidly. Along with the automation of organic synthesis and biochemical screening, this is bringing a major change in the whole field of drug discovery research.
A. Ghose, and Vellarkad N. Viswanadhan, J. Wendoloski   +2 more
semanticscholar   +1 more source