One-Pot Parallel Synthesis of Unclosed CryptandsSearching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques [PDF]
ACS Omega, 2020 We present the synthesis of 17 macrocyclic compounds having the structure of so-called unclosed cryptands, acting as anion receptors. These compounds possess amide functions playing the role of hydrogen-bond-donating systems. We have synthesized the presented compounds both by standard methods (using batch conditions) and by static combinatorial ...
Patryk Niedbała, Janusz Jurczak
doaj +4 more sources
Old and Modern Antibiotic Structures with Potential for Today’s Infections
ADMET and DMPK, 2022 Due to the lack of new antibiotics with efficacy against the ESKAPE and other resistant microbes, coupled to the demise of major pharmaceutical company antibiotic discovery programs, due to a number of factors but mainly ROI calculations and the lack of ...
David Newman
doaj +1 more source
Exploring chemical space and structural diversity of supramolecular peptide materials
Supramolecular Materials, 2023 Searching chemical space and expanding the structural diversity of supramolecular self-assembly based on the development of combinatorial libraries is significant to the guided design of bio-inspired materials.
Mengyue Zhu, Jing Chen, Yiyang Lin
doaj +1 more source
Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches
Pharmaceutics, 2022 The delivery of drugs via transdermal routes is an attractive approach due to ease of administration, bypassing of the first-pass metabolism, and the large skin surface area.
Victor Hmingthansanga +5 more
doaj +1 more source
Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses. [PDF]
PLoS ONE, 2013 The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine ...
Guohua Yi +11 more
doaj +1 more source
Combinatorial Chemistry: A Guide for Librarians.
Issues in Science and Technology Librarianship, 2002 In the 1980s a need to synthesize many chemical compounds rapidly and inexpensively spawned a new branch of chemistry known as combinatorial chemistry.
Philip Barnett
doaj +1 more source
Combinatorial structures to modeling simple games and applications [PDF]
, 2017 We connect three different topics: combinatorial structures, game theory and chemistry. In particular, we establish the bases to represent some simple games, defined as influence games, and molecules, defined from atoms, by using combinatorial structures.
Molinero Albareda, Xavier
core +1 more source
Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
doaj +1 more source
Similarity-based data mining in files of two-dimensional chemical structures using fingerprint measures of molecular resemblance [PDF]
, 2011 This paper reviews the use of measures of intermolecular similarity for processing databases of chemical structures, which play an important role in the discovery of new drugs by the pharmaceutical industry.
Willett, P.
core +1 more source
Visual and computational analysis of structure-activity relationships in high-throughput screening data [PDF]
, 2001 Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. This paper reviews recent
Agrafiotis +75 more
core +1 more source