One-Pot Parallel Synthesis of Unclosed CryptandsSearching for Selective Anion Receptors via Static Combinatorial Chemistry Techniques [PDF]
ACS Omega, 2020 We present the synthesis of 17 macrocyclic compounds having the structure of so-called unclosed cryptands, acting as anion receptors. These compounds possess amide functions playing the role of hydrogen-bond-donating systems. We have synthesized the presented compounds both by standard methods (using batch conditions) and by static combinatorial ...
Patryk Niedbała, Janusz Jurczak
doaj +5 more sources
Novel Screening Technique: Integrated Combinatorial Green Chemistry & Life Cycle Analysis (CGC-LCA)
BioResources, 2013 The integration of combinatorial green chemistry (CGC), a more benign approach to combinatorial chemistry, with environmental life cycle assessment (LCA) methodologies as an improved process development methodology is discussed. It is expected that the CGC approach will require less labor and result in more globally optimized assay results, leading to ...
Richard A. Venditti +2 more
openaire +5 more sources
Buchbesprechung: Analytical Techniques in Combinatorial Chemistry. Von Michael E. Swartz. [PDF]
Angewandte Chemie, 2001 Jörg W. Metzger
openaire +3 more sources
Molecular Modeling, Computational/ Combinatorial Chemistry, and Chemical Diversity: Methods and Techniques [PDF]
Chemical & Engineering News Archive, 1997 openaire +2 more sources
Old and Modern Antibiotic Structures with Potential for Today’s Infections
ADMET and DMPK, 2022 Due to the lack of new antibiotics with efficacy against the ESKAPE and other resistant microbes, coupled to the demise of major pharmaceutical company antibiotic discovery programs, due to a number of factors but mainly ROI calculations and the lack of ...
David Newman
doaj +1 more source
Improved Topical Drug Delivery: Role of Permeation Enhancers and Advanced Approaches
Pharmaceutics, 2022 The delivery of drugs via transdermal routes is an attractive approach due to ease of administration, bypassing of the first-pass metabolism, and the large skin surface area.
Victor Hmingthansanga +5 more
doaj +1 more source
Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses. [PDF]
PLoS ONE, 2013 The development of an effective AIDS vaccine has been a formidable task, but remains a critical necessity. The well conserved membrane-proximal external region (MPER) of the HIV-1 gp41 glycoprotein is one of the crucial targets for AIDS vaccine ...
Guohua Yi +11 more
doaj +1 more source
Development of Advanced Macrosphelides: Potent Anticancer Agents
Molecules, 2015 Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography ...
Seung-Mann Paek
doaj +1 more source
CHIMIA, 2003 This review aims at giving a short introduction to the most important areas of library design. The description of compounds by descriptors and fingerprints, and similarity-based clustering techniques are illustrated in the context of untargeted ...
Friederike Stoll
doaj +1 more source
Química Nova, 2005 Combinatorial chemistry refers to techniques to rapidly fabricate tens, hundreds or even thousands of different micro samples. The analysis of the large number of samples generated by combinatorial methods requires highly efficient analytical methods. In
Najla Maroun Estrada +3 more
doaj +1 more source