Results 11 to 20 of about 15,411 (236)

Library Design

CHIMIA, 2003
This review aims at giving a short introduction to the most important areas of library design. The description of compounds by descriptors and fingerprints, and similarity-based clustering techniques are illustrated in the context of untargeted ...
Friederike Stoll
doaj   +1 more source

Química combinatória de materiais com análise por microdifração de raios X. Primeira parte: fundamentos Combinatorial chemistry of materials with analysis by X-ray microdiffraction. Part I: fundamentals

Química Nova, 2005
Combinatorial chemistry refers to techniques to rapidly fabricate tens, hundreds or even thousands of different micro samples. The analysis of the large number of samples generated by combinatorial methods requires highly efficient analytical methods. In
Najla Maroun Estrada, Francisco Manoel dos Santos Garrido, Marta Eloisa Medeiros, Sérgio de Paula Machado   +3 more
doaj   +1 more source

Computational Enumeration of Colorings of Hyperplanes of Hypercubes for all Irreducible Representations and Applications

Journal of Mathematical Sciences and Modelling, 2018
We obtain the generating functions for the combinatorial enumeration of colorings of all hyperplanes of hypercubes for all irreducible representations of the hyperoctahedral groups.
Krishnan Balasubramanian
doaj   +1 more source

Versatile Monitoring Tools in Parallel Solid-Phase Synthesis

CHIMIA, 2003
Parallel synthesis on solid-phase is routinely applied in our combinatorial chemistry efforts for lead finding and lead optimization in drug discovery.
Eduard R. Felder, Katia Martina, Simona Scarpella, Marco Tatò   +3 more
doaj   +1 more source

DNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution.

PLoS Biology, 2004
Biological in vitro selection techniques, such as RNA aptamer methods and mRNA display, have proven to be powerful approaches for engineering molecules with novel functions.
David R Halpin, Pehr B Harbury
doaj   +1 more source

Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation

ADMET and DMPK, 2020
Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids.
Shashi Kiran Misra, Kamla Pathak
doaj   +1 more source

Upgrading SELEX Technology by Using Lambda Exonuclease Digestion for Single-Stranded DNA Generation

Molecules, 2009
The generation of single-stranded DNA (ssDNA) molecules plays a key role in the SELEX (Systematic Evolution of Ligands by EXponential enrichment) combinatorial chemistry process and numerous molecular biology techniques and applications, such as DNA ...
Meltem Avci-Adali, Angel Paul, Nadj Wilhelm, Gerhard Ziemer, Hans Peter Wendel   +4 more
doaj   +1 more source

Ultrasonic surface acoustic wave-assisted separation of microscale droplets with varying acoustic impedance

Ultrasonics Sonochemistry, 2023
In droplet-based microfluidic platforms, precise separation of microscale droplets of different chemical composition is increasingly necessary for high-throughput combinatorial chemistry in drug discovery and screening assays.
Mushtaq Ali, Jinsoo Park
doaj   +1 more source

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.

PLoS Biology, 2020
As a novel alternative to established surface display or combinatorial chemistry approaches for the discovery of therapeutic peptides, we present a method for the isolation of small, cysteine-rich domains from bovine antibody ultralong complementarity ...
Alex Macpherson, Anthony Scott-Tucker, Anastasios Spiliotopoulos, Catherine Simpson, Justin Staniforth, Adam Hold, James Snowden, Leah Manning, Jean van den Elsen, Alastair D G Lawson   +9 more
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Microbial Identification, High-Resolution Microscopy and Spectrometry of the Rhizosphere in Its Native Spatial Context

Frontiers in Plant Science, 2021
During the past decades, several stand-alone and combinatorial methods have been developed to investigate the chemistry (i.e., mapping of elemental, isotopic, and molecular composition) and the role of microbes in soil and rhizosphere.
Chaturanga D. Bandara, Matthias Schmidt, Yalda Davoudpour, Hryhoriy Stryhanyuk, Hans H. Richnow, Niculina Musat   +5 more
doaj   +1 more source