Results 41 to 50 of about 172,692 (298)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Phage display screening of therapeutic peptide for cancer targeting and therapy

Protein & Cell, 2019
Recently, phage display technology has been announced as the recipient of Nobel Prize in Chemistry 2018. Phage display technique allows high affinity target-binding peptides to be selected from a complex mixture pool of billions of displayed peptides on ...
Phei Er Saw, Er-Wei Song
doaj   +1 more source

Structure and singly occupied molecular orbital analysis of anionic tautomers of guanine [PDF]

, 2008
Recently we reported the discovery of adiabatically bound anions of guanine which might be involved in the processes of DNA damage by low-energy electrons and in charge transfer through DNA.
Abdoul-Carime, Aflatooni, Aflatooni, Atkins, Bachorz, Berlin, Bixo, Boudaïffa, Cai, Cai, Carhart, Dolgounitcheva, Downs, Downs, Frisch, Gutowski, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Haranczyk, Hendricks, Henkelman, Hert, Holliday, Humphrey, Kendall, Kendall, Li, Li, Mazurkiewicz, Messer, Periquet, Ptasinska, Sanville, Seidel, Straatsma, Taylor, Tonzani, Wesolowski, Willett, Zakjevskii   +42 more
core   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Protein-Directed Dynamic Combinatorial Chemistry: A Guide to Protein Ligand and Inhibitor Discovery

Molecules, 2016
Protein-directed dynamic combinatorial chemistry is an emerging technique for efficient discovery of novel chemical structures for binding to a target protein.
Renjie Huang, Ivanhoe K. H. Leung
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Explorando produtos naturais microbianos nas fronteiras da Química e da Biologia

Química Nova, 2013
The chemistry of natural products has been remarkably growing in the past few decades in Brazil. Aspects related to the isolation and identification of new natural products, as well as their biological activities, have been achieved in different ...
Luciana Gonzaga de Oliveira, Mônica Tallarico Pupo, Paulo Cezar Vieira   +2 more
doaj   +1 more source

Experimental library screening demonstrates the successful application of computational protein design to large structural ensembles [PDF]

, 2010
The stability, activity, and solubility of a protein sequence are determined by a delicate balance of molecular interactions in a variety of conformational states.
A. Nisthal, Allen, Allen, Ambroggio, Arnold, Aucamp, B. D. Allen, Bershtein, Boas, Byeon, Chica, Dahiyat, Dahiyat, Dirks, Dirks, DUNBRACK-JR., Fu, Gordon, Gordon, Grigoryan, Grigoryan, Gronenborn, Guerois, Havranek, Jee, Jiang, Kirsten Frank, Kono, Kuhlman, Larson, Lippow, Malakauskas, Mendes, Pokala, Rohl, Rothlisberger, S. L. Mayo, Schneider, Schueler-Furman, Shortle, Word, Yin   +41 more
core   +3 more sources

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source