Results 41 to 50 of about 69,229 (270)
Explorando produtos naturais microbianos nas fronteiras da Química e da Biologia
Química Nova, 2013 The chemistry of natural products has been remarkably growing in the past few decades in Brazil. Aspects related to the isolation and identification of new natural products, as well as their biological activities, have been achieved in different ...
Luciana Gonzaga de Oliveira +2 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Virtual Ligand Screening for Structure-based Drug Design: Approaches and Progress [PDF]
Bioautomation, 2007 Recent progress in human genomics and proteomics has significantly increased the number of macromolecular targets potentially involved in drug discovery campaigns.
Olivier Sperandio +2 more
doaj
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries [PDF]
, 2003 Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries.
Bohl, M. +6 more
core +1 more source
Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents
Pharmaceutics, 2020 Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX.
Prabir Kumar Kulabhusan +2 more
doaj +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
A rapid screening, “combinatorial-type” survey of the metalloligand chemistry of Pt₂(PPh₃)₄(μ-S)₂ using electrospray mass spectrometry [PDF]
, 2001 Electrospray mass spectrometry is a rapid and powerful technique for a combinatorial-like survey of the chemistry of the metalloligand Pt₂(PPh₃)₄(μ-S)₂, leading to the successful isolation and crystallographic characterisation of the novel protonated ...
Fong, S.W. Audi +5 more
core +2 more sources
Natural product-like combinatorial libraries
Journal of the Brazilian Chemical Society, 2003 Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj
Education SciencesCurrent higher education trends are moving towards interdisciplinary curricula to provide new tools for solving complex issues. However, course design and learning tracks still create divisions between scientific disciplines. This study aimed to evaluate
Nadav Badrian +3 more
doaj +1 more source