Results 61 to 70 of about 436,297 (318)
Current Perspectives on Aptamers as Diagnostic Tools and Therapeutic Agents
Pharmaceutics, 2020 Aptamers are synthetic single-stranded DNA or RNA sequences selected from combinatorial oligonucleotide libraries through the well-known in vitro selection and iteration process, SELEX.
Prabir Kumar Kulabhusan +2 more
doaj +1 more source
FEBS Letters, EarlyView.α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley +1 more source
Scaffold searching: automated identification of similar ring systems for the design of combinatorial libraries [PDF]
, 2003 Rigid ring systems can be used to position receptor-binding functional groups in 3D space and they thus play an increasingly important role in the design of combinatorial libraries.
Bohl, M. +6 more
core +1 more source
Natural product-like combinatorial libraries
Journal of the Brazilian Chemical Society, 2003 Combinatorial chemistry has emerged over the last few years as an important tool for drug discovery and lead optimisation. In this approach, the molecular diversity and range of biological properties displayed by secondary metabolites constitutes a ...
Abreu Pedro M., Branco Paula S.
doaj
Education SciencesCurrent higher education trends are moving towards interdisciplinary curricula to provide new tools for solving complex issues. However, course design and learning tracks still create divisions between scientific disciplines. This study aimed to evaluate
Nadav Badrian +3 more
doaj +1 more source
Insights of Novel Coronavirus (SARS-CoV-2) disease outbreak, management and treatment
AIMS Microbiology, 2020 Emerging and re-emerging viral diseases poses a threat to living organisms, and led to serious concern to humankind and public health. The last two decades, viral epidemics such as the severe acute respiratory syndrome(SARS-CoV) reported in the years ...
Dharmender Kumar +2 more
doaj +1 more source
A non-Hermitian Ground State Searching Algorithm Enhanced by Variational Toolbox [PDF]
arXiv, 2022 Ground-state preparation for a given Hamiltonian is a common quantum-computing task of great importance and has relevant applications in quantum chemistry, computational material modeling, and combinatorial optimization. We consider an approach to simulate dissipative non-Hermitian Hamiltonian quantum dynamics using Hamiltonian simulation techniques ...
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Application Performance Benchmarks for Quantum Computers [PDF]
arXiv, 2023 Current technological advancements of quantum computers highlight the need for application-driven, practical and well-defined methods of benchmarking their performance. As the existing NISQ device's quality of two-qubit gate errors rate is even around one percent and the number of qubits is still limited to a few or several dozen, naturally, we need to
arxiv
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source