Results 61 to 70 of about 69,229 (270)
The Phytochemical Ingredients and Therapeutic Potential of Cynara scolymus L.
Pharmaceutical and Biomedical Research, 2021 Background: Medicinal herbs remain a vital source of new chemical entities, instead of the attempt of pharmaceutical companies using combinatorial and synthetic chemistry techniques for developing new drugs.
Sanjay Agarwal +3 more
doaj
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
High throughput microbalance and methods of using same [PDF]
, 2007 The method and apparatus is particularly adapted for providing microbalance measurement of solid materials as part of a combinatorial research program.
Carlson, Eric +4 more
core
Combinatorial Space Tiling [PDF]
, 2010 The present article studies combinatorial tilings of Euclidean or spherical spaces by polytopes, serving two main purposes: first, to survey some of the main developments in combinatorial space tiling; and second, to highlight some new and some old open ...
Schulte, Egon
core
Rewriting the dendritic cell code in cancer—from subset identity to immunotherapeutic design
FEBS Letters, EarlyView.Dendritic cells (DCs) play central roles in cancer immunity but are often subverted by the tumor microenvironment. This review explores the diversity of DC subsets, their functional plasticity, and emerging therapeutic strategies to reprogram DCs for enhanced antitumor responses, including vaccines, in vivo targeting, and DC‐based immunotherapies ...
Estevão Carlos Silva Barcelos +3 more
wiley +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Generic Strategies for Chemical Space Exploration [PDF]
, 2014 Computational approaches to exploring "chemical universes", i.e., very large sets, potentially infinite sets of compounds that can be constructed by a prescribed collection of reaction mechanisms, in practice suffer from a combinatorial explosion.
Andersen, Jakob L. +3 more
core +1 more source
Aptamers: A new approach to detection of target molecules [PDF]
فصلنامه ابن سینا, 2016 Background: For more than three decades, antibodies were recognized as the most common class of diagnostic molecules with a wide range of applications, until aptamers became as widespread as antibodies.
M ebrahimi, R Lalavi
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