Results 61 to 70 of about 172,692 (298)

Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides [PDF]

, 2009
Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic fungi Botrytis cinerea and Colletotrichum ...
Aleu J., Aleu J., Aleu J., Barbosa D., Barbosa de Oliveira D., Burkert U., Bustillo A. J., Bustillo A. J., Bustillo A. J., Clark T., Coleman T. F., Coleman T. F., Coley-Smith J. R., Colmenares A. J., Cruciani G., Cruz-Monteagudo M., Cruz-Monteagudo M., De Boor C., Duke S. O., Echeverri F., Efron B., Eriksson L., Gerald C. F., Gramatica P., Hasegawa K., Hou T. J., Leardi R., Patil I. S., Reino J. L., Saiz-Urra L., Van Waterbeemd H., Yasri A.   +31 more
core   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Combinatorial high throughput methodologies: the potentials in heterogeneous catalysts synthesis, screening and discovery—a review

Bulletin of the National Research Centre
Background Catalysis represents a critical field that greatly contributes to human living, technology, economic growth and the environment. Compact catalysts have frequently been applied in manufacturing a range of substances and fuels, thus essentially ...
Jovine Kamuhabwa Emmanuel
doaj   +1 more source

Insights of Novel Coronavirus (SARS-CoV-2) disease outbreak, management and treatment

AIMS Microbiology, 2020
Emerging and re-emerging viral diseases poses a threat to living organisms, and led to serious concern to humankind and public health. The last two decades, viral epidemics such as the severe acute respiratory syndrome(SARS-CoV) reported in the years ...
Dharmender Kumar, Lalit Batra, Mohammad Tariq Malik   +2 more
doaj   +1 more source

$\mathcal{G}$-SELC: Optimization by sequential elimination of level combinations using genetic algorithms and Gaussian processes

, 2009
Identifying promising compounds from a vast collection of feasible compounds is an important and yet challenging problem in the pharmaceutical industry.
Mandal, Abhyuday, Ranjan, Pritam, Wu, C. F. Jeff   +2 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

DNA Computing by Self-Assembly [PDF]

, 2003
Information and algorithms appear to be central to biological organization and processes, from the storage and reproduction of genetic information to the control of developmental processes to the sophisticated computations performed by the nervous ...
Winfree, Erik
core  

Surface free energy and microarray deposition technology [PDF]

, 2007
Microarray techniques use a combinatorial approach to assess complex biochemical interactions. The fundamental goal is simultaneous, large-scale experimentation analogous to the automation achieved in the semiconductor industry.
Aussillous, Blossey, Cheran, Deegan, Deegan, Glen McHale, McHale, Wixforth, Wixforth   +8 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

A Dual Bioconjugated Virus-Like Nanoparticle as a Drug Delivery System and Comparison with a pH-Responsive Delivery System

Nanomaterials, 2018
Modifications of virus-like nanoparticles (VLNPs) using chemical conjugation techniques have brought the field of virology closer to nanotechnology. The huge surface area to volume ratio of VLNPs permits multiple copies of a targeting ligand and drugs to
Roya Biabanikhankahdani, Kok Lian Ho, Noorjahan Banu Alitheen, Wen Siang Tan   +3 more
doaj   +1 more source