Results 201 to 210 of about 53,849 (278)

Defining the parameters of comet assay for reliably detecting DNA damage as a marker of X-ray based irradiation in insects treated with non-lethal doses for export fruit sanitation. [PDF]

Pest Manag Sci
Hiszczynska-Sawicka E, Richards NK, Gibson JL, van Koten C, Gunawardana D, Armstrong KF.   +5 more
europepmc   +1 more source

CometAnalyser: A user-friendly, open-source deep-learning microscopy tool for quantitative comet assay analysis. [PDF]

Comput Struct Biotechnol J, 2022
Beleon A, Pignatta S, Arienti C, Carbonaro A, Horvath P, Martinelli G, Castellani G, Tesei A, Piccinini F.   +8 more
europepmc   +1 more source

Prolonged exposure to artificial light and carcinogenesis: A systematic review of oncostatic mechanisms associated with melatonin pathways

Photochemistry and Photobiology, EarlyView.
Exposure to artificial light at night (ALAN), particularly at blue wavelengths, disrupts circadian rhythms by suppressing melatonin, thereby increasing cancer susceptibility. This systematic review consolidates evidence linking prolonged ALAN exposure to an elevated risk of breast and prostate tumors.
Gabriel Barboza, Jêmina Oliveira, Antônio Ferreira, Renan Lopes, Marli Cupertino   +4 more
wiley   +1 more source

Optimization of concentrations and exposure durations of commonly used positive controls in the in vitro alkaline comet assay. [PDF]

Toxicol Res (Camb)
Tekneci Sİ, Üstündağ A, Duydu Y.
europepmc   +1 more source

Genotoxicity study of 2-methoxyethanol and benzalkonium chloride through Comet assay using 3D cultured HepG2 cells. [PDF]

Environ Anal Health Toxicol, 2022
Lim C, Shin K, Seo D.
europepmc   +1 more source

Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine

Photochemistry and Photobiology, EarlyView.
6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes, Fernanda M. Prado, Helena C. Junqueira, Marisa H. G. Medeiros, Graziella E Ronsein, Jean Cadet, Paolo Di Mascio   +6 more
wiley   +1 more source

Impact of (poly)phenol-rich dietary sources on DNA damage: insights from human intervention studies using the Comet assay - a review and perspective. [PDF]

Br J Nutr
Milev M, Roglev B, Kondeva Rogleva M, Georgieva M, Miloshev G, Ruskovska T.   +5 more
europepmc   +1 more source

RAD51 and RAD51 paralog inhibition sensitizes nonreplicating quiescent keratinocytes to UV radiation

Photochemistry and Photobiology, EarlyView.
UV radiation and other compounds generate DNA adducts that block transcription and induce cell death if not removed by the nucleotide excision repair system. In this work, we used a small‐scale pharmacological screen to discover that inhibition of the recombinase RAD51 sensitized nonreplicating quiescent keratinocytes to both UVR and other agents that ...
Saman Khan, Angitha Nair, M. Alexandra Carpenter, Michael G. Kemp   +3 more
wiley   +1 more source

Oxidative DNA Damage and Repair Dynamics in Multiple Sclerosis: Insights from Comet Assay Kinetics, Base Excision Repair Gene Expression, and Genotype Analysis. [PDF]

Biomolecules
Filipek B, Macieja A, Binda A, Szelenberger R, Gorniak L, Miller E, Swiderek-Matysiak M, Stasiolek M, Majsterek I, Poplawski T.   +9 more
europepmc   +1 more source

Measurement of DNA Damage Using the Neutral Comet Assay in Cultured Cells. [PDF]

Bio Protoc, 2021
Clementi E, Garajova Z, Markkanen E.
europepmc   +1 more source