Results 211 to 220 of about 51,303 (237)

A plant cell‐based platform for the expression of complex proteins with fucose‐reduced sialylated N‐glycans

Plant Biotechnology Journal, EarlyView.
Saeideh Dianatkhah, Benjamin Kogelmann, Stanislav Melnik, Florian Eminger, Somanath Kallolimath, Lin Sun, Delia Sumesgutner, Michael W. Traxlmayr, Markus Sack, Eva Stoger, Herta Steinkellner   +10 more
wiley   +1 more source

An insect †Archaeopteryx: Cretaceous amber fossil elucidates the evolution of complex host detection and ovipositor mechanisms in parasitoid woodwasps (Hymenoptera: Orussoidea)

Systematic Entomology, Volume 50, Issue 3, Page 630-645, July 2025.
We describe †Cretovelona orussopteryx n. gen. & sp. from Kachin amber. The fossil is examined with synchrotron scanning and integrated into an existing morphological data set for Orussoidea. This fossil parasitoid wasp displays a unique character combination demonstrating intermediate conditions in evolving the complex features employed in echo ...
Lars Vilhelmsen, Brendon E. Boudinot, Jörg U. Hammel, Hiroshi Nakamine, Shûhei Yamamoto   +4 more
wiley   +1 more source

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Angewandte Chemie International Edition, Volume 64, Issue 25, June 17, 2025.
A biosynthesis route for the polymer precursor tulipalin A starting from isoprenyl acetate is proposed. The alkane monooxygenase AlkB catalyzes the chemoselective terminal hydroxylation of isoprenyl acetate. Rational enzyme engineering further increased the activity of the membrane enzyme.
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Prospects of Using Tidal Tomography to Constrain Ganymede's Interior

Geophysical Research Letters, Volume 52, Issue 11, 16 June 2025.
Abstract Juice (JUpiter ICy moons Explorer) 3GM Radio Science Experiment will map the gravitational field of Ganymede with unprecedented accuracy and measure tidally‐induced variations. These measurements will allow the characterization of its putative ocean and may resolve lateral variations in internal structure.
M. Rovira‐Navarro, I. Matsuyama, D. Dirkx, A. Berne, D. Calliess, S. Fayolle   +5 more
wiley   +1 more source

Dawn‐Dusk Asymmetry of Kelvin‐Helmholtz Vortices Along the Kronian Magnetopause

Geophysical Research Letters, Volume 52, Issue 11, 16 June 2025.
Abstract The Kelvin‐Helmholtz instability (KHI) at the Kronian magnetopause is an important process resulting from the interaction between the magnetosphere and the solar wind. The Kronian magnetosphere is rotationally driven, thus dawn‐dusk asymmetry has been observed in the KHI structures.
Enhao Feng, Zhiqi Zheng, Binzheng Zhang, Zhonghua Yao, Peter A. Delamere   +4 more
wiley   +1 more source

Transforming a Historical Chemical Synthetic Route for Vanillin Starting from Renewable Eugenol to a Cell‐Free Bi‐Enzymatic Cascade

ChemSusChem, Volume 18, Issue 11, June 2, 2025.
An artificial enzymatic cascade to access natural vanillin from eugenol/clove oil was developed by revisiting the very first vanillin synthetic process from 19th century. The biosynthetic route consists of just two biocatalysts used as cell‐free preparation and molecular oxygen as oxidizing agent, outperforming also the natural microbial pathway which ...
Elisa Lanfranchi, Valerio Ferrario, Somayyeh Gandomkar, Stefan E. Payer, Erna Zukic, Haris Rudalija, Alexandra Musi, Ines Gaberscek, Yuliya Orel, Doreen Schachtschabel, Christian Willrodt, Michael Breuer, Wolfgang Kroutil   +12 more
wiley   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, Volume 19, Issue 6, Page 1633-1650, June 2025.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Reproducibility in machine‐learning‐based research: Overview, barriers, and drivers

AI Magazine, Volume 46, Issue 2, Summer 2025.
Abstract Many research fields are currently reckoning with issues of poor levels of reproducibility. Some label it a “crisis,” and research employing or building machine learning (ML) models is no exception. Issues including lack of transparency, data or code, poor adherence to standards, and the sensitivity of ML training conditions mean that many ...
Harald Semmelrock, Tony Ross‐Hellauer, Simone Kopeinik, Dieter Theiler, Armin Haberl, Stefan Thalmann, Dominik Kowald   +6 more
wiley   +1 more source

Nuclear‐Localized BCKDK Facilitates Homologous Recombination Repair to Support Breast Cancer Progression and Therapy Resistance

Advanced Science, Volume 12, Issue 22, June 12, 2025.
Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu, Jiaqian Feng, Tingting Pan, Pinggen Zhang, Ling Ye, Zetan Jiang, Zilong Zhou, Qiankun Mao, Jian Li, Xinyi Yang, Ping Gao, De Huang, Huafeng Zhang   +12 more
wiley   +1 more source

Strengthening the reporting of diet item details in feeding studies measuring the dietary metabolome: The DID‐METAB core outcome set statement

European Journal of Clinical Investigation, Volume 55, Issue 7, July 2025.
Jessica J. A. Ferguson, Erin D. Clarke, Jordan Stanford, María Gómez‐Martín, Tammie Jakstas, Clare E. Collins, DID‐METAB Delphi Working Group Authors, Kathryn L. Beck, Catalina Cuparencu, David P. De Souza, Kerith Duncanson, Mar Garcia‐Aloy, Lihi Godny, James O. Hill, Elaine Holmes, Deborah A. Kerr, Rachel Kimble, Francine Z. Marques, Megan A. McCrory, Charlotte E. Mills, George Moschonis, Kay Nguo, Dorit Samocha‐Bonet, Matthew Snelson, Heidi M. Staudacher, Maria H. Traka, Caroline J. Tuck   +26 more
wiley   +1 more source