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The Comet Moment as a Measure of DNA Damage in the Comet Assay
International Journal of Radiation Biology, 1995The development of rapid assays of radiation-induced DNA damage requires the definition of reliable parameters for the evaluation of dose-response relationships to compare with cellular endpoints. We have used the single-cell gel electrophoresis (SCGE) or 'comet' assay to measure DNA damage in individual cells after irradiation.
C.R.H. Kent +3 more
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Impact of the comet assay in radiobiology
Mutation Research/Reviews in Mutation Research, 2009Until the development of single cell gel electrophoresis methods in the 1980s, measurement of radiation-induced DNA strand breaks in individual cells was limited to detection of micronuclei or chromosome breaks that measured the combined effects of exposure and repair.
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Genotoxicity of Contaminants: Comet Assay
2013International ...
Devaux, Alain, Bony, Sylvie
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2009
The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is ...
Alok Dhawan, Diana Anderson
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The vast number of chemicals existing or being added into the environment, have globally aroused great concern regarding their adverse effects in human population. Development and validation of sensitive and better test systems which can assess the adverse effects of chemicals at an early stage for intervention strategies to be implemented in time is ...
Alok Dhawan, Diana Anderson
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The In Vitro and In Vivo Comet Assays
2011The strategy for testing for genotoxicity covers three main areas, namely gene mutation, chromosome aberration or breakage (clastogenicity), and chromosome loss or gain (aneuploidy). The current generalized strategy consists of assays capable of detecting all of these endpoints using in vitro assays such as the Ames test for detecting gene mutations in
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Comet assay in genetic ecotoxicology: A review
Environmental and Molecular Mutagenesis, 1999The Comet assay, also called the single cell gel electrophoresis (SCGE) assay or microgel electrophoresis (MGE) assay, primarily measures DNA strand breakage in single cells. Since the protocol was published by Singh et al. [1988], its use has increased in different topic areas: clinical applications, human monitoring, radiation biology, genetic ...
Sylvie Cotelle, Jean-François Férard
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Environmental Monitoring & Assessment, 2020
Luís F. O. Knapik, W. Ramsdorf
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Luís F. O. Knapik, W. Ramsdorf
semanticscholar +1 more source
2009
Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Michael J. Plewa, Elizabeth D. Wagner
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Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Michael J. Plewa, Elizabeth D. Wagner
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The enzyme-modified comet assay: past, present and future.
Food and Chemical Toxicology, 2020D. Muruzabal, A. Collins, A. Azqueta
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Pesticide genotoxicity in cotton picking women in Pakistan evaluated using comet assay
Drug and chemical toxicology (New York, N.Y. 1978), 2018T. Ali +5 more
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