Results 311 to 320 of about 58,125 (347)
Some of the next articles are maybe not open access.
The Comet Assay in Human Biomonitoring
Human biomonitoring studies aim to identify potential exposures to environmental, occupational, or lifestyle toxicants in human populations and are commonly used by public health decision-makers to predict disease risk. The Comet assay measures changes in genomic stability and is one of the most reliable biomarkers to indicate early biological effects,Mojgan, Najafzadeh +3 more
openaire +2 more sources
2009
Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Elizabeth D. Wagner, Michael J. Plewa
openaire +1 more source
Among the manifold advantages of the Comet assay is the ability to evaluate very limited amounts of test agents. In many cases compounds for a research study are not commercially available and the chemicals must be individually synthesised at great expense and with large amounts of time involved.
Elizabeth D. Wagner, Michael J. Plewa
openaire +1 more source
Genotoxicity of Contaminants: Comet Assay
2013International ...
Devaux, Alain, Bony, Sylvie
openaire +2 more sources
The In Vitro and In Vivo Comet Assays
2011The strategy for testing for genotoxicity covers three main areas, namely gene mutation, chromosome aberration or breakage (clastogenicity), and chromosome loss or gain (aneuploidy). The current generalized strategy consists of assays capable of detecting all of these endpoints using in vitro assays such as the Ames test for detecting gene mutations in
openaire +2 more sources
Impact of the comet assay in radiobiology
Mutation Research/Reviews in Mutation Research, 2009Until the development of single cell gel electrophoresis methods in the 1980s, measurement of radiation-induced DNA strand breaks in individual cells was limited to detection of micronuclei or chromosome breaks that measured the combined effects of exposure and repair.
openaire +2 more sources
The Comet Assay in Nano-ecogenotoxicology
Comet assay is a quick and versatile technique for assessing DNA damage in individual cells. It allows the detection of DNA single- and double-strand breaks, as well as the presence of alkali-labile sites and cross-links. Here we describe protocols for the Single-Cell Gel Electrophoresis (Comet assay) in its alkaline (pH > 13), mild alkaline (pH = 12.1)Patrizia, Guidi, Giada, Frenzilli
openaire +2 more sources
Segmentation of the Comet Assay Images
2004The single cell gel electrophoresis, called Comet Assay, is a microelectrophoretic technique of direct visualization of the DNA damage at the cell level. In the comet assay, the cells suspended in an agarose gel on a microscope slide are subjected to lysis, unwinding of DNA and electrophoresis.
Bogdan Smolka, Rastislav Lukac
openaire +1 more source
Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?
Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2022Amaya Azqueta +2 more
exaly