Results 31 to 40 of about 8,069 (192)

Redistribution of DNA loop domains in human lymphocytes under blast transformation with interleukin 2 [PDF]

The Ukrainian Biochemical Journal, 2016
At higher order levels chromatin fibers in interphase nuclei are organized into loop domains. Gene regulatory elements (promoters and enhancers) are often located near the sites of loop attachments.
K. S. Afanasieva, M. I. Chopei, A. V. Lozovik, S. R. Rushkovsky, A. V. Sivolob   +4 more
doaj   +1 more source

Pro‐ATO/Allicin Liposomes for Dual‐Pathway Targeting of p53‐Mutant Tumors

Advanced Science, EarlyView.
Schematic illustration of the “pro‐ATO”/allicin liposomal strategy. Liposomal encapsulation improves the stability and bioavailability of both agents while masking allicin's odor. Upon release in the tumor microenvironment, ATO reactivates structural p53 mutants, and allicin inhibits ATR signaling while releasing H2S, collectively inducing synthetic ...
Xiaoling Xu, WeiYi Cheng, Menghang Yang, Li He, WeiYe Ren, JingQuan Chen, LiTing He, Dandan Bao, Zhihong Zhu, Lixin Wang, Qinghua Yao, Ji‐Gang Piao   +11 more
wiley   +1 more source

Parent Volatile Outgassing Associations in Cometary Nuclei: Synthesizing Rosetta Measurements and Ground-based Observations

The Planetary Science Journal
Comets, as remnants of the solar system’s formation, vary in volatile-refractory content. In situ comet studies, such as the Rosetta mission to 67P/Churyumov–Gerasimenko, provide detailed volatile composition insights, while ground-based studies offer ...
Mohammad Saki, Dennis Bodewits, Boncho P. Bonev, Neil Dello Russo, Adrienn Luspay-Kuti, John W. Noonan, Michael. R. Combi, Yinsi Shou   +7 more
doaj   +1 more source

Six Outbursts of Comet 46P/Wirtanen

The Planetary Science Journal, 2021
Cometary activity is a manifestation of sublimation-driven processes at the surface of nuclei. However, cometary outbursts may arise from other processes that are not necessarily driven by volatiles.
Michael S. P. Kelley, Tony L. Farnham, Jian-Yang Li, Dennis Bodewits, Colin Snodgrass, Johannes Allen, —, Eric C. Bellm, Michael W. Coughlin, Andrew J. Drake, Dmitry A. Duev, Matthew J. Graham, Thomas Kupfer, Frank J. Masci, Dan Reiley, Richard Walters, Zwicky Transient Facility Collaboration, M. Dominik, U. G. Jørgensen, A. E. Andrews, N. Bach-Møller, V. Bozza, M. J. Burgdorf, J. Campbell-White, S. Dib, Y. I. Fujii, T. C. Hinse, M. Hundertmark, E. Khalouei, P. Longa-Peña, M. Rabus, S. Rahvar, S. Sajadian, J. Skottfelt, J. Southworth, J. Tregloan-Reed, E. Unda-Sanzana, MiNDSTEp Collaboration   +37 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Ground-based Support of Comet Nuclei Space Missions [PDF]

Symposium - International Astronomical Union, 2004
There are currently five space missions en route to or planned for comet encounters. It is important for the success of each mission that its target be characterized as fully as possible prior to the encounter. This progress report analyses initial photometric results for 11 comet nuclei for the Stardust, Rosetta, Deep Impact, CONTOUR, Deep Space 1 ...
Jana Pittichová, Karen J. Meech
openaire   +1 more source

Detection of comet nuclei at large heliocentric distances [PDF]

Monthly Notices of the Royal Astronomical Society, 1992
The largest long-period comets which have passed perihelion during the past half-century should still be observable. Fourteen candidate comets with well-determined orbits are presented, including data on their absolute magnitudes, distances and predicted positions in the sky.
M. E. Bailey, J. E. Chambers, G. Hahn
openaire   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source