Results 41 to 50 of about 144,914 (237)
National Journal of Clinical Anatomy, 2023 Background: Sperm is more than just a mere transporter of paternal genetic information, although serving purposes other than conception. DNA integrity (DI) is regarded as a crucial aspect of semen quality and has great significance in predicting male ...
Balachandran Sivaraja Ganesan +1 more
doaj +1 more source
Lung Ultrasound Comet Tails — Technique and Clinical Significance
, 2013 While often overlooked by traditional echocardiography, the lungs and evaluation of extrava‐ scular lung water (EVLW) can be assessed by direct visualization with relatively simple ultrasonographic techniques.
D. Summerfield, Bruce Johnson
semanticscholar +1 more source
Endogenous Amplification of Apoptosis via p53 Regulation using a Cascade Nanocatalytic Medicine
Advanced Science, EarlyView.An engineered MOF nanomedicine (MAL) triggers cascade nanocatalysis in tumors, converting H2O2 and L‐Arg into cytotoxic peroxynitrite. This induces DNA damage, activates the p53 pathway, and amplifies mitochondrial apoptosis via the BAX/Bcl‐2/Caspase‐3 axis, effectively inhibiting colorectal cancer growth with high biocompatibility.
Tan Wu +8 more
wiley +1 more source
RAD18 confers radioresistance of esophagus squamous cell carcinoma through regulating p‐DNA‐PKcs
Cancer Medicine, 2022 Background Radiotherapy has recently become more common for the treatment of esophageal squamous cell carcinoma (ESCC). Radioresistance, on the other hand, continues to be a major issue because it interferes with the effectiveness of ESCC radiation.
Xiaoqing Li +8 more
doaj +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji +10 more
wiley +1 more source
Hubble Space Telescope Observations of the Interstellar Interloper 3I/ATLAS
The Astrophysical Journal LettersWe present high-angular-resolution observations of the third known interstellar interloper, 3I/ATLAS, from the Hubble Space Telescope. The object is clearly active at 3.8 au preperihelion, showing dust emitted from the hot, Sun-facing side of the nucleus
David Jewitt +4 more
doaj +1 more source
Cell Death Discovery, 2023 Radiotherapy resistance is an important and urgent challenge in the clinical management of esophageal squamous carcinoma (ESCC). However, the factors mediating the ESCC resistance to radiotherapy and its underlying molecular mechanisms are not fully ...
Xiaoqing Li +12 more
doaj +1 more source
In vitro cytotoxicity of curcuminoids against head and neck cancer HNO97 cell line
Brazilian Journal of Biology, 2021 Oral squamous cell carcinoma (OSCC) is a malignant tumour of Head and Neck Cancer (HNC). The recent therapeutic approaches used to treat cancer have adverse side effects.
Z. Almalki +5 more
doaj +1 more source
Advanced Science, EarlyView.Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan +8 more
wiley +1 more source