Results 41 to 50 of about 439,605 (315)

Barcelona, a Society and its Law: 11th-13th Centuries

open access: yesCatalan Historical Review, 2008
The legal system in Barcelona in the Lower Middle Ages — which we regard as a synthesis of rights (usages, customs, privileges, laws, and so on) and organization (municipality, universitat de prohoms, consulates, etc.)− had already attained maturity in ...
Tomàs de Montagut
doaj  

Céramiques glaçurées et à décor vert et brun des épaves islamiques de Provence (fin IXe-début Xe siècle)

open access: yesArqueología y Territorio Medieval, 2020
Aborder le thème des mobiliers céramiques glaçurés, qui constituent une part, somme toute, assez modeste des cargaisons étudiées des épaves islamiques de Provence, revêt toutefois une importance cruciale en terme de diffusion des techniques et savoir ...
Chaterine Richarté-Manfredi
doaj  

El asentamiento orientalizante e ibérico antiguo de "La Rábita", Guardamar del Segura (Alicante). Avance de las excavaciones 1996-1998

open access: yesTrabajos de Prehistoria, 1998
[es] Al sur de la desembocadura del río Segura, la excavación de La Rábita califal ha revelado la existencia, en el mismo lugar, de un establecimiento de época Orientalizante/Protoibérica e Ibérica Antigua. El hábitat, cuya historia empieza probablemente
Rafael Azuar   +5 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

Supply to the population in Kraljevo from 1911 to 1951 [PDF]

open access: yesBaština, 2014
Kraljevo was one of the most destroyed town in Serbia during the Second World War. The town suffered a lot of causalities and significant destruction of infrastructure. All economic-related activities during the war were almost benumbed, and agricultural
Simijanović Jovan D.
doaj  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Advances in Inventory Accuracy and Packaging Innovation for Minimizing Returns and Damage in E-Commerce Logistics [PDF]

open access: bronze, 2022
Oyinomomo-emi Emmanuel Akpe   +4 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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