Results 41 to 50 of about 2,093,061 (342)
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
Jack Balkin\u27s Interaction Theory of “Commerce” [PDF]
, 2011 In his book, Living Originalism, Jack Balkin proposes what he calls the “interaction theory” of the original semantic meaning of the word “commerce” in the Commerce Clause.
Barnett, Randy E
core +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
PENGAWASAN TERHADAP PEMUNGUTAN PAJAK PENGHASILAN ATAS TRANSAKSI ELEKTRONIK (E- COMMERCE) [PDF]
, 2016 Transaksi e-commerce merupakan aktifitas perdagangan yang dilakukan dalam dunia maya yang berkaitan dengan pembelian, penjualan, pemasaran barang ataupun jasa dengan memanfaatkan sistem elektronik seperti internet ataupun jaringan komputer.
Cicierdis , Ifanurdiani
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Deep Cascade Multi-task Learning for Slot Filling in Online Shopping Assistant
, 2019 Slot filling is a critical task in natural language understanding (NLU) for dialog systems. State-of-the-art approaches treat it as a sequence labeling problem and adopt such models as BiLSTM-CRF.
Chen, Xi +8 more
core +1 more source
Les Cahiers ALHIM, 2019 This article presents a general approximation of the commercial activity between the city of Cadiz and the Hispanic American colonies from 1765 to the threshold of the nineteenth century.
Gloria de los Ángeles Zarza Rondón
doaj +1 more source
Trade and Diplomacy in the Autumn of Crimea (1768-1769)
Avrasya İncelemeleri Dergisi, 2023 This study explores trade and commercial diplomacy in Crimea just before the Ottoman–Russian War (1768–1774). During this period, the Black maintained its status quo, effectively remaining closed to foreign-flagged ships.
Ensar Köse
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Equality of Arms in the Digital Age [PDF]
, 2008 Electronic commerce is important, and perhaps, inevitable. Thus to consider the legal implications of the growth and development of electronic commerce is essential.
Haloush, Haitham +2 more
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