Results 51 to 60 of about 828,402 (267)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Dynamic viscoelasticity of commercial mayonnaise: influence of temperature and oil content
Grasas y Aceites, 1991 The linear dynamic viscoelasticity of two commercial foodstuffs, oil in water emulsions with very different oil contents, has been studied. Temperature ranged between 10 and 40°C.
M. Berjano, C. Gallegos
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The speech communication btween the shape and content in commercial advertising
الاكاديمي, 2017 The Main think that be kept by the speech communication as a concept traditionally being expressed on the subject or a certain idea of a goal came on as needed functional addressed to recipients of benefits or likely to benefit from those rhetorical ...
fouad ahmed alsammaraee
doaj +1 more source
Animals, 2020 The aim of the present study is to investigate the physical parameters and fatty acid composition and related nutritional parameters of market-procured table eggs from Milanino, Mericanel della Brianza and Valdarnese Bianca hens compared to two ...
Stefano Paolo Marelli +6 more
doaj +1 more source
IMPROVEMENT OF METHODOLOGICAL PRINCIPLES OF BRAND PROTECTION IN CYBERSPACE
Фінансово-кредитна діяльність: проблеми теорії та практики, 2023 The main purpose of this scientific work is to improve the theoretical and methodological foundations of ensuring data protection in cyberspace in the direction of forming a brand protection system to increase its level of recognition, strengthen ...
Oksana Zghurska +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Bile-acid content of a commercial secretin
Journal of Pharmacy and Pharmacology, 1985 Abstract Secretin, produced by the Boots Co., is an adsorbate on ox and pig bile acids of secretin from pig duodenum prepared after the method of Crick et al (1950). It is to be expected that this product will not only stimulate the secretion of fluid and electrolytes by the pancreas and the liver but that it will also increase the ...
D, Kyffin, I, McLean, S C, Rutishauser
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source