Results 91 to 100 of about 1,427,464 (308)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Visual Models, Procedural Fluency, and Multiple Strategies: A Cognitive Critique of Common Core Elementary Mathematics

open access: yesNonpartisan Education Review
This paper examines the cognitive and curricular problems of Common Core elementary mathematics. Through analysis of Big Ideas Math and related instructional practices, it argues that, visual representations are employed excessively and without ...
Qianruo Shen
doaj  

Common Core Genes Play Vital Roles in Gastric Cancer With Different Stages. [PDF]

open access: yesFront Genet, 2022
Yu Z   +7 more
europepmc   +1 more source

Navigating the Common Core with English Language Learners Practical Strategies to Develop Higher-Order Thinking Skills

open access: yes
Intro -- More Praise for Navigating the Common Core with English Language Learners -- Title Page -- Copyright -- Table of Contents -- About the Authors -- About the Contributors -- Acknowledgments -- Introduction -- Notes -- Chapter 1: English Language ...
Sypnieski, Katie Hull., Ferlazzo, Larry.
core  

2021-2022 Common Data Set - Wright State University Lake Campus

open access: yes, 2021
The 2021-2022 Common Data Set of Wright State University Lake Campus from the Princeton Review. It includes data on admissions, student enrollment, faculty, class size, financial aid and other measures, using standard definitions that aid comparisons ...
Princeton Review   +1 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Common core variables for childhood cancer data integration

open access: yesEJC Paediatric Oncology
Introduction: Data-driven research has improved paediatric cancer outcomes for children. However, challenges in sharing data between institutions prevent the use of artificial intelligence (AI) to address substantial unmet needs in children diagnosed ...
Daniela Di Carlo   +6 more
doaj   +1 more source

English Common Core 6th Grade

open access: yes
Pronoun Case L.6.1a -- Intensive & -- ReflexivePronouns L.6.1b -- Shifts in PronounNumber & -- Person L.6.1c -- Unclear or AmbiguousPronouns L.6.1d -- Variations fromStandard English L.6.1e -- Parentheticals L.6.2a -- Spelling L.6.2b -- Varying ...
BarCharts, Inc.
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

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