Results 51 to 60 of about 7,183,098 (196)

Common variable immune deficiency with mutated TNFSRF13B gene presenting with autoimmune hematologic manifestations

Pediatric Hematology Oncology Journal, 2016
Patients with common variable immunodeficiency (CVID) develop autoimmune hematologic manifestations. We report a 14-year-old boy with Evans syndrome, who presented at the age of 11.5 years with autoimmune hemolysis and was successfully managed with ...
Elpis Mantadakis, Evangelia Farmaki, Anna Taparkou, Athanassios Chatzimichael, Matthaios Speletas   +4 more
doaj   +1 more source

Common Variable Immunodeficiency (CVID) and Inclusion Body Myositis (IBM)

Immunobiology, 2000
A case of a 38-year old man with a common variable immunodeficiency syndrome (CVID) is demonstrated who suffered at the same time from a histologically proven inclusion body myositis (IBM). The myositis did not resolve after institution of regular intravenous IgG infusions. This case demonstrates a very long lasting benign course of IBM. The occurrence
A, Gause, D C, Inderrieden, R, Laas, A C, Arlt, W L, Gross   +4 more
openaire   +2 more sources

CHAPLE‐Like Enteropathy and Renal Microangiopathy in an Adult Patient With CD46 Deficiency

Journal of Clinical Laboratory Analysis, Volume 40, Issue 21, November 2026.
We report an adult patient with a homozygous CD46 variant presenting with lifelong protein‐losing enteropathy, intestinal lymphangiectasia, and CVID‐like hypogammaglobulinemia mimicking CHAPLE syndrome. Concurrent renal biopsy revealed PLA2R‐negative membranous nephropathy with chronic thrombotic microangiopathy, establishing multi‐organ complement ...
Bircan Erden, Pelin Korkmaz, Halil Yazici, Ahmet Burak Dirim, Fatih Beşışık, Nevzat Kahveci, Zeynep Kilinc, Derya Unal, Osman Ozan Yegit, Tuğba Kalaycı, Özge Hürdoğan, Yasemin Özlük, Melek Büyük, Asli Gelincik, Semra Demir   +14 more
wiley   +1 more source

Profound Perturbation : Immunopathological Mechanisms in Common Variable Immunodeficiency [PDF]

, 2005
The integrity of all organisms to injury is conserved through intricate mechanisms of response, but none more so than the immune system of the mammals. The complexity and potency of these mechanisms make them both difficult and intriguing to dissect, but
T Ueland, Fevang, Børre, S S Frøland, L Heggelund, A M Holm, P Aukrust, J K Damås, T E Mollnes, B Fevang   +8 more
core   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

T-Cell Abnormalities in Common Variable Immunodeficiency

, 2016
Common variable immunodeficiency (CVID) is the most common clinical primary immunodeficiency. It is characterized by a defect in B-cell differentiation to plasma and memory B cells.
Mirshafiey, A., Azizi, G., Rezaei, N., Aghamohammadi, A., Tavakolinia, N., Yazdani, R., Kiaee, F.   +6 more
core   +1 more source

Noncaseating Granulomatous Disease in Common Variable Immunodeficiency

, 2000
Patients with common variable immunodeficiency (CVID) are occasionally recognized to have a concurrent noncaseating granulomatous disease. The granulomatous disease (GD) associated with CVID shares many clinical properties typical of sarcoidosis.
Byrd, R P., Roy, T. M., Kanathur, N, Fields, C L.   +3 more
core   +1 more source

Microbiome and Tumor Microenvironment Interactions: Advances From Ecological Niches to Precision Oncology

Cancer Nexus, Volume 2, Issue 4, October 2026.
Tumor‐associated microbiota occupies spatially organized ecological niches and influence cancer progression by reshaping tumor‐cell signaling, metabolism, immunity, stromal remodeling, and therapeutic response. Integrating microbiome‐derived biomarkers, targeted microbial interventions, spatial multi‐omics, longitudinal monitoring, and AI may enable ...
Yiwen Zhang, Ji'an Liu, Jing Li, Xue Liu, Yang Su, Peng Luo, Yuhan Zhang, Zhengrui Li   +7 more
wiley   +1 more source

Immunoglobulin a Deficiency in Coeliac Disease: A Scoping Review

United European Gastroenterology Journal, Volume 14, Issue 8, October 2026.
ABSTRACT Coeliac disease (CeD) and immunoglobulin A deficiency (IgAD) frequently co‐occur and share a genetic background within the HLA‐DQ2 region. Although this has been known for decades, the underlying mechanisms linking the two conditions remain unclear.
Kristine Bech, Cæcilie Crawley, Rok Seon Choung, Joseph A. Murray, Steffen Husby   +4 more
wiley   +1 more source

Review Article: Immune Effector Cell‐Mediated Enterocolitis Following CAR‐T Cell Therapy—Clinical Features, Pathophysiology and Management

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 8, Page 1046-1057, October 2026.
Immune effector cell‐mediated enterocolitis is an emerging complication of CAR‐T therapy. This review summarizes its epidemiology, pathophysiology, diagnosis, endoscopic and histopathologic features, and evidence‐based management, emphasizing early recognition, multidisciplinary intervention, and step‐up therapy.
John A. Damianos, Yi Lin, Zongming Eric Chen, Kenneth J. C. Lim, Navreet M. Chowla   +4 more
wiley   +1 more source