Results 71 to 80 of about 9,757,173 (343)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Diethylene glycol poisoning in Gurgaon, India, 1998

Bulletin of the World Health Organization
OBJECTIVE: To discover the cause of acute renal failure in 36 children aged 2 months to 6 years who were admitted to two hospitals in Delhi between 1 April and 9 June 1998.
Jagvir Singh, A.K. Dutta, Shashi Khare, N.K. Dubey, A.K. Harit, N.K. Jain, T.C. Wadhwa, S.R. Gupta, A.C. Dhariwal, D.C. Jain, Rajesh Bhatia, Jotna Sokhey   +11 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

International law and communicable diseases

Bulletin of the World Health Organization, 2002
Historically, international law has played a key role in global communicable disease surveillance. Throughout the nineteenth century, international law played a dominant role in harmonizing the inconsistent national quarantine regulations of European ...
Aginam Obijiofor
doaj  

The association of inflammatory markers in early pregnancy with the development of gestational diabetes: Qazvin maternal and neonatal metabolic study (QMNS)

BMC Pregnancy and Childbirth
Background This study investigates the association of blood cell components and blood cell-derived inflammatory indices in early pregnancy with the development of gestational diabetes mellitus (GDM).
Sima Hashemipour, Seyedeh Sareh Kalantarian, Hamidreza Panahi, Sara Esmaeili Kelishomi, Amirabbas Ghasemi, Sarah Mirzaeei Chopani, Sepideh Kolaji, Milad Badri, Arefeh Ghobadi, Seyyed Mohammad Reza Hadizadeh Khairkhahan, Fatemeh Lalooha, Farideh Movahed, Mahnaz Abbasi, Khadijeh Elmizadeh   +13 more
doaj   +1 more source

Whole-genome sequencing for surveillance of Salmonella at a public health institution in South Africa

African Journal of Laboratory Medicine
Background: Whole-genome sequencing (WGS) is transforming communicable disease surveillance globally. The National Institute for Communicable Diseases, South Africa, participates in national laboratory-based surveillance for human isolates of Salmonella.
Anthony M. Smith, Phuti Sekwadi, Hlengiwe M. Ngomane, Bolele Disenyeng, Linda K. Erasmus, Juno Thomas, Dineo Bogoshi, Shannon L. Smouse, Nomsa P. Tau   +8 more
doaj   +1 more source

Analysis of a temporal cluster of Shigella boydii isolates in Mpumalanga, South Africa, November to December 2007

Journal of Infection in Developing Countries, 2009
Background: Shigellosis is a global human health problem. The disease is most prevalent in developing countries with poor access to safe potable water and sanitation.
Anthony M. Smith, Karen H. Keddy, Arvinda Sooka, Husna Ismail, Gillian M. DeJong   +4 more
doaj   +1 more source

Rubella seroprevalence using residual samples from the South African measles surveillance program: a cross-sectional analytic study

Human Vaccines & Immunotherapeutics, 2020
Introduction: South Africa is yet to introduce rubella-containing vaccines (RCV) into its routine immunization schedule. Selecting the target population when introducing RCV should take into account the ages of susceptible individuals in the population ...
N. V. Motaze, L. Makhathini, S. B. Smit, C. G. Adu-Gyamfi, M. Fortuin, C. S. Wiysonge, S. M. Suchard   +6 more
doaj   +1 more source

Microbiological and clinical characteristics of invasive Group B Streptococcal blood stream infections in children and adults from Qatar

BMC Infectious Diseases, 2022
Introduction Group B Streptococci (GBS) colonize almost one third of human gastrointestinal and genitourinary tracts, particularly in females. The aim of this study is to evaluate the epidemiology, microbiological characteristics, and clinical outcomes ...
Maisa Ali, Mohammed A. Alamin, Gawahir A. Ali, Khalid Alzubaidi, Bashir Ali, Abdellatif Ismail, Joanne Daghfal, Muna Almaslamani, Hamad Abdel Hadi   +8 more
doaj   +1 more source

Modelling and prediction of global non-communicable diseases

BMC Public Health, 2020
Background Non-communicable diseases (NCDs) are the main health and development challenge facing humankind all over the world. They are inextricably linked to socio-economic development.
Yang-Cheng Wang, Jinfeng Wang
semanticscholar   +1 more source