Results 31 to 40 of about 412,791 (238)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Langue(s) & Parole, 2019 L’articulation de la lecture et la production des textes est la pierre angulaire de l’apprentissage du français langue étrangère (FLE). En effet, savoir lire des textes ne suffit pas. C’est sur la base des épreuves écrites que l’on évalue la réussite de
Mustapha Belhadj
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Alternative Francophone, 2023 Faire apprendre l’usage d’une langue nécessite non seulement le repérage de cet usage mais aussi la modélisation didactique de celui-ci: il s’agit de distinguer soigneusement ce que fait l’usager expert (ayant à accomplir des actions authentiques) de ...
Mansour Chamkhi
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 2007 Téboul-Weber Valérie. Compétence. In: Quaderni, n°63, Printemps 2007. Nouveaux mots du pouvoir : fragments d'un abécédaire. pp.
Téboul-Weber, Valérie
core +1 more source
Compétence : un levier dans la fixation des salaires et/ou l’employabilité dans une organisation [PDF]
Mouvements et Enjeux Sociaux, 2022 L’objet de cet article est de montrer que certains déterminants (qualification, ancienneté, etc.) considérés jadis comme seuls critères dans la fixation des salaires et de l’employabilité du personnel dans une organisation deviennent aujourd’hui, tout ...
KITAMBALA KABEMBA, OMAMBUDI EKUDI
doaj
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source