Results 31 to 40 of about 429,775 (239)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Langue(s) & Parole, 2019 L’articulation de la lecture et la production des textes est la pierre angulaire de l’apprentissage du français langue étrangère (FLE). En effet, savoir lire des textes ne suffit pas. C’est sur la base des épreuves écrites que l’on évalue la réussite de
Mustapha Belhadj
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Alternative Francophone, 2023 Faire apprendre l’usage d’une langue nécessite non seulement le repérage de cet usage mais aussi la modélisation didactique de celui-ci: il s’agit de distinguer soigneusement ce que fait l’usager expert (ayant à accomplir des actions authentiques) de ...
Mansour Chamkhi
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Passerelle: This article examines the question of the use of generative artificial intelligence in writing workshops in an Algerian university context and reports on an experiment carried out with students enrolled in a Master I literature course.
Soumia AOUNALLAH +1 more
doaj +1 more source
, 2019 Bien que la « compétence » soit un mot connu du vocabulaire juridique, le droit du travail l’utilise dans une autre perspective : celle de désigner l’habileté des salariés.
Thomas, Sarah, Casaux-Labrunée, Lise
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Compétence : un levier dans la fixation des salaires et/ou l’employabilité dans une organisation [PDF]
Mouvements et Enjeux Sociaux, 2022 L’objet de cet article est de montrer que certains déterminants (qualification, ancienneté, etc.) considérés jadis comme seuls critères dans la fixation des salaires et de l’employabilité du personnel dans une organisation deviennent aujourd’hui, tout ...
KITAMBALA KABEMBA, OMAMBUDI EKUDI
doaj