Results 41 to 50 of about 429,775 (239)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

How are Professional Programs from Diverse Disciplines Approaching the Development and Assessment of Competence at a Mid-Sized Canadian University?

Canadian Journal for the Scholarship of Teaching and Learning, 2020
Time-honoured university policies, such as the credit-hour and academic freedom, present challenges for professional education programs tasked with operationalizing entry-to-practice competence frameworks for professional accreditation.
Jessica Rich, Don Klinger, Sue Fostaty Young, Catherine Donnelly   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Objectif Compétence. Pour une nouvelle logique

, 1999
Cet ouvrage présente le développement de la logique compétence dans toutes ses dimensions. Après un rappel des acquis des expérimentations passées dans ce domaine, et après avoir associé logique compétence et mutations du travail, l'auteur part du “noyau
Zarifian, Philippe
core   +3 more sources

Mais qu’évaluent donc les enquêtes internationales ?

Revue Internationale d’Éducation de Sèvres, 2006
International surveys have the virtue of existing. They are excellent indicators, yet they are only indicators. They must be given meaning and value (after all, “to evaluate” does etymologically mean “to extirpate value from”).
Jean-Marie De Ketele
doaj   +1 more source

Repenser l’éducation artistique : l’exemple du Sénégal [PDF]

Akofena, 2022
Résumé : L’enseignement et la formation d’un enfant d’un terroir bien déterminé doivent s’appuyer sur ses réalités culturelles pour atteindre les objectifs fixés par les politiques publiques dans le domaine de l’éducation.
El Hadji Tafsir Baba Ndao DIOUF
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Validation of competence models for developing education standards: Methodological choices and their consequences

Mesure et Évaluation en Éducation, 2008
Following PISA 2000, Switzerland launched a project called HarmoS (Harmonization of obligatory School) to develop binding education standards for compulsory education in the three language regions of the country.
Erich Ramseier
doaj   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source