Results 21 to 30 of about 2,398,914 (265)

Development of Cell-Specific Aptamers: Recent Advances and Insight into the Selection Procedures

Molecules, 2017
Systematic evolution of ligands by exponential enrichment (SELEX) is an established procedure for developing short single-stranded nucleic acid ligands called aptamers against a target of choice.
Kamal Rahimizadeh, Hadi AlShamaileh, Milena Fratini, Madhuri Chakravarthy, Michelle Stephen, Sarah Shigdar, Rakesh N. Veedu   +6 more
doaj   +1 more source

Rational Design of Short Locked Nucleic Acid-Modified 2′-O-Methyl Antisense Oligonucleotides for Efficient Exon-Skipping In Vitro

Molecular Therapy: Nucleic Acids, 2017
Locked nucleic acid is a prominent nucleic acid analog with unprecedented target binding affinity to cDNA and RNA oligonucleotides and shows remarkable stability against nuclease degradation.
Bao T. Le, Abbie M. Adams, Susan Fletcher, Stephen D. Wilton, Rakesh N. Veedu   +4 more
doaj   +1 more source

Complete mitochondrial genome of Mekong fighting fish, Betta smaragdina (Teleostei: Osphronemidae)

Mitochondrial DNA. Part B. Resources, 2021
Mekong fighting fish (Betta smaragdina) are found in Northeast Thailand. A complete mitochondrial genome (mitogenome) of B. smaragdina was assembled and annotated.
Nararat Laopichienpong, Syed Farhan Ahmad, Worapong Singchat, Aorarat Suntronpong, Tavun Pongsanarm, Kornsuang Jangtarwan, Jakaphan Bulan, Tanawat Pansrikaew, Thitipong Panthum, Nattakan Ariyaraphong, Navapong Subpayakom, Sahabhop Dokkaew, Narongrit Muangmai, Prateep Duengkae, Kornsorn Srikulnath   +14 more
doaj   +1 more source

Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis [PDF]

, 2009
BACKGROUND: The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization (FISH) and microarray resources facilitate comparative genomic studies between ...
Ioannou, D., Völker, Martin, Robertson, Lindsay, Langley, Elizabeth J, Robertson, Lindsay BW, Tempest, Helen G, Skinner, Benjamin M., Tempest, Helen G., Tempest, H., Völker, M., Skinner, M., Crooijmans, Richard P.M.A., Hall, Anthony D, Fowler, K., Skinner, Benjamin M, Robertson, L.B., Crooijmans, Richard PMA, Skinner, B., Fowler, Katie E., Griffin, Darren K, Langley, E.J., Crooijmans, R.P.M.A., Griffin, D., Hall, A., Robertson, L., Tempest, H.G., Ioannou, Dimitris, Fowler, K.E., Crooijmans, R., Griffin, Darren K., Langley, E.   +30 more
core   +1 more source

Comparative RNA genomics

, 2022
S.363-400Over the last two decades it has become clear that RNA is much more than just a boring intermediate in protein expression. Ancient RNAs still appear in the core information metabolism and comprise a surprisingly large component in bacterial gene
Hofacker, Ivo L., Gorodkin, Jan, Stadler, Peter F., Backofen, Rolf   +3 more
core   +1 more source

Novel Chemically-modified DNAzyme targeting Integrin alpha-4 RNA transcript as a potential molecule to reduce inflammation in multiple sclerosis

Scientific Reports, 2017
Integrin alpha-4 (ITGA4) is a validated therapeutic target for multiple sclerosis (MS) and Natalizumab, an antibody targeting ITGA4 is currently approved for treating MS. However, there are severe side effects related to this therapy.
Madhuri Chakravarthy, May T. Aung-Htut, Bao T. Le, Rakesh N. Veedu   +3 more
doaj   +1 more source

RNA-Seq and iTRAQ reveal multiple pathways involved in storage root formation and development in sweet potato (Ipomoea batatas L.)

BMC Plant Biology, 2019
Background Sweet potato (Ipomoea batatas L.) is the sixth most important food crop in the world. The formation and development of storage roots in sweet potato is a highly complicated and genetically programmed process. However, the underlying mechanisms
Tingting Dong, Mingku Zhu, Jiawen Yu, Rongpeng Han, Cheng Tang, Tao Xu, Jingran Liu, Zongyun Li   +7 more
doaj   +1 more source

Mitochondrial genome of bronze-winged jacana (Metopidius indicus, Latham 1790)

Mitochondrial DNA. Part B. Resources, 2021
We reported the mitochondrial genome (mitogenome) of bronze-winged jacana (Metopidius indicus, Latham ). The circular mitogenome was 17,208 base pairs (bp) in length, containing 13 protein-coding genes, two rRNAs, 22 tRNAs, and a non-coding control ...
Jitmat Thintip, Syed Farhan Ahmad, Worapong Singchat, Nararat Laopichienpong, Aorarat Suntronpong, Thitipong Panthum, Dung Ho My Nguyen, Nattakan Ariyaraphong, Narongrit Muangmai, Warong Suksawet, Prateep Duengkae, Kornsorn Srikulnath   +11 more
doaj   +1 more source

Antisense Oligonucleotide-Mediated Terminal Intron Retention of the SMN2 Transcript

Molecular Therapy: Nucleic Acids, 2018
The severe childhood disease spinal muscular atrophy (SMA) arises from the homozygous loss of the survival motor neuron 1 gene (SMN1). A homologous gene potentially encoding an identical protein, SMN2 can partially compensate for the loss of SMN1 ...
Loren L. Flynn, Chalermchai Mitrpant, Ianthe L. Pitout, Sue Fletcher, Steve D. Wilton   +4 more
doaj   +1 more source

A drug repurposing screen for whipworms informed by comparative genomics. [PDF]

, 2023
Hundreds of millions of people worldwide are infected with the whipworm Trichuris trichiura. Novel treatments are urgently needed as current drugs, such as albendazole, have relatively low efficacy.
Brown, A.E., Duque-Correa M.A., Berriman, M., Partridge, F.A., Clare, S., Nick, M., Brandt, C., Seymour, L., Mkandawire, T.T., McCarthy, C., Holroyd, N., Coghlan A., Rinaldi, G.   +12 more
core   +1 more source