Results 81 to 90 of about 2,688,225 (235)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Compensatory recruitment allows amphibian population persistence in anthropogenic habitats.

, 2022
Habitat anthropization is a major driver of global biodiversity decline. Although most species are negatively affected, some benefit from anthropogenic habitat modifications by showing intriguing life-history responses.
Léna, Jean-Paul, Di Cerbo, Anna R, Giachi, Filippo, Enderlin, Nadine, Moquet, Julien, Endrizzi, Sonia, Trenti, Matteo, Vanni, Stefano, Tiberi, Andrea, Vignoli, Leonardo, Monod-Broca, Benjamin, Hantzschmann, Alena M, Krijnen, Peter, Bunz, Yoann, Gollmann, Birgit, Barrioz, Mickael, Morizet, Yohan, Lemaître, Jean-François, Rosa, Giacomo, Biaggini, Marta, Laurenceau, Florian, Pedrini, Paolo, Veen, Robert, Bernard, Laurent, Corail, Marc, Hertach, Thomas, Gailledrat, Miguel, Rivière, Laurent, Leclerc, Titouan, Venchi, Alberto, Gollmann, Günter, Biancardi, Carlo, Langlois, Dominique, Cruickshank, Sam S, Henseler, Dominik, Aumaître, Damien, Morin, Lucy, Gippet, Jérôme M W, Spitzen-van der Sluijs, Annemarieke, Canessa, Stefano, Besnard, Aurélien, Angelini, Claudio, Skrzyniarz, Mégane, Schmidt, Benedikt R, Dudgeon, David, Kinet, Thierry, Doré, Florian, Maletzky, Andreas, Delsinne, Thibaut, Tournier, Emilie, Fonters, Remi, Cayuela, Hugo, Gaillard, Jean-Michel, Bonnaire, Eric, Buschmann, Holger, Romano, Antonio, Laudelout, Arnaud, Thirion, Jean-Marc, Boussiquault, Elodie, Carafa, Marco, Pichenot, Julian, Sinsch, Ulrich   +61 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories

, 2005
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of its consequences for evolution by natural selection ...
Weinreich, Daniel M., Watson, Richard A., Chao, Lin   +2 more
core   +1 more source

Consuming Costly Prey: Optimal Foraging and the Role of Compensatory Growth

, 2021
Some prey are exceptionally difficult to digest, and yet even non-specialized animals may consume them—why? Durophagy, the consumption of hard-shelled prey, is thought to require special adaptations for crushing or digesting the hard shells to avoid the ...
Langerhans, Randall Brian, Riesch, Rüdiger, Araújo, Márcio S. [UNESP], Stemp, Kenzi M., Layman, Craig A., Goins, Taylor R.   +5 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Data from: The roles of compensatory evolution and constraint in aminoacyl tRNA synthetase evolution

, 2015
Mitochondrial protein translation requires interactions between transfer RNAs encoded by the mitochondrial genome (mt-tRNAs) and mitochondrial aminoacyl tRNA synthetase proteins (mt-aaRS) encoded by the nuclear genome.
Adrion, Jeffrey R., Montooth, Kristi L., White, P. Signe   +2 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Intratracheal Administration of Recombinant Human Keratinocyte Growth Factor Promotes Alveolar Epithelial Cell Proliferation during Compensatory Lung Growth in Rat [PDF]

, 2013
Keratinocyte growth factor (KGF) is considered to be one of the most important mitogens for lung epithelial cells. The objectives of this study were to confirm the effectiveness of intratracheal injection of recombinant human KGF (rhKGF) during ...
Nanashima, Atsushi, Matsumoto, Keitaro, Yamamoto-Fukuda, Tomomi, Abo, Takafumi, Tsuchiya, Tomoshi, Koji, Takehiko, 古川, 克郎, Nagayasu, Takeshi, Obatake, Masayuki, Tobinaga, Shuichi, Miyazaki, Takuro, Furukawa, Katsuro, Kamohara, Ryotaro, Yamasaki, Naoya   +13 more
core   +1 more source