Results 121 to 130 of about 821,290 (231)

Compensatory mutations in the matrix protein of viral hemorrhagic septicemia virus (VHSV) genotype IVa in response to artificial mutation of two amino acids (D62A E181A). [PDF]

Virus Res, 2023
Kim SY, Kwak JS, Jung W, Kim MS, Kim KH.
europepmc   +1 more source

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity [PDF]

, 2012
An attenuation of the HIV-1 replication capacity (RC) has been observed for immune-mediated escape mutations in Gag restricted by protective HLA alleles.
Olvera, A., Markle, T.J., Cheung, P.K., John, M., Brumme, Z.L., Brumme, C.J., Carlson, J.M., Kelleher, A.D., Markowitz, M., Frahm, N., McGovern, R., Harrigan, P.R., Brander, C., Heckerman, D., Sanchez, J., Walker, B.D., Chopera, D.R., Sela, J., Le, A.Q., Jessen, H., Martin, E., Rosenberg, E., Brockman, M.A., Mallal, S.   +23 more
core  

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

LRG1 Drives Pathological Angiogenesis by Disrupting Neutrophil Mitochondrial Homeostasis in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer, LRG1 binds to ANXA2 to trigger mitochondrial ROS‐dependent NETosis. This pathogenic cascade actively uncouples endothelial‐mural cell interactions, driving profound vascular destabilization. Consequently, targeting the LRG1‐ANXA2 axis attenuates the neutrophil burden and induces structural vascular normalization, offering a powerful ...
Dongshan Chen, Cong Zhang, Song Xue, Yuan Zeng, Haochen Cui, Chenfei Wang, Jiayi Feng, Lei Yan, Yuanwei Zang   +8 more
wiley   +1 more source

Global genetic rewiring during compensatory evolution in the yeast polarity network

EMBO Reports
Functional defects resulting from deleterious mutations can often be restored during evolution by compensatory mutations. Importantly, this process can generate the genetic diversity seen in networks regulating the same biological function in different ...
Enzo Kingma, Marieke Glazenburg, Karel Olavarria, Liedewij Laan   +3 more
doaj   +1 more source

Between compensatory mutations and synthetic lethals: genetic mutations, a new challenge for tomorrow's medicine

, 2014
International audienceIn the macromolecular world, the evolution of two building blocks (two nucleotides or two amino acids) can be interdependent in various ways, including: (i) a mutation at one site compensates a deleterious mutation at another site ...
Coupaye, Rémi, Bazin, Claude, Middendorp, Sandrine, Vanet, Anne   +3 more
core   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

Advanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku, Jinwon Kwon, Nara Yoon, Hyung Kwon Byeon, Jaemoon Yang   +4 more
wiley   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

Molecular Dynamic Simulation data of compensatory mutations in Bruton's Tyrosine Kinase

, 2019
The research aims to find compensatory mutations that rescue Bruton’s tyrosine kinase (Btk) activity in the presence of severe X-linked agammaglobulinemia (XLA) causing mutation in the kinase domain. The data set includes the molecular dynamic simulation
Nikita Chopra (2580964), Amy H. Andreotti (366314), Kejue Jia (8102966), Robert Jernigan (23908)   +3 more
core   +1 more source