Results 31 to 40 of about 155,761 (229)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

L’avaluació de competències a l’Educació Superior: el cas d’un màster universitari

open access: yesRevista d'Innovació i Recerca en Educació, 2013
La implantació de les competències és una tasca que ha anat incorporant-se paulatinament pels docents de la universitat espanyola amb l’entrada en vigor del EEES.
Xavier Triadó i Ivern   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Competències de la Comissió Europea [PDF]

open access: yes, 2023
En aquesta publicació comente les competències de la Comissió ...
Carro Pitarch, María
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Resoldre problemes per aprendre a fer ciències

open access: yesRevista Catalana de Pedagogia, 2018
Es considera que el motor que impulsa la creació de coneixement científic, així com la seva evolució al llarg de la història, és la resolució de problemes. En aquest article considerem que també pot generar coneixement científic als centres d’ensenyament
Mercè Izquierdo Aymerich
doaj  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Aprenentatge Basat en Projectes en àmbits STEM : claus metodològiques i reptes

open access: yesCiències, 2017
El desenvolupament competencial de les àrees científiques ha trobat en l'Aprenentatge Basat en Projectes un espai didàctic candidat. El treball coordinat des de les diverses disciplines (Ciències, Tecnologia, Enginyeria i Matemàtiques) permet aprendre ...
Jordi Domenech Casal
doaj   +1 more source

Competències del Consell Europeu [PDF]

open access: yes, 2023
En aquesta publicació comente les competències del Consell Europeu.In this publication I discuss the competences of the European ...
Carro Pitarch, María
core  

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