Results 41 to 50 of about 155,761 (229)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

open access: yesFEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan   +4 more
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

open access: yesFEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana   +3 more
wiley   +1 more source

El blindatge de les competències i la reforma estatutària

open access: yesRevista Catalana de Dret Públic, 2005
L’experiència del desenvolupament de l’autonomia al llarg dels darrers 25 anys mostra una reducció notable de les competències de la Generalitat respecte de les expectatives inicials i un procés persistent d’erosió, per diverses vies, que ha limitat la ...
Enoch Albertí Rovira
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Big Eight +12. : Test de competències d'empleabilitat [PDF]

open access: yes, 2015
Test Situacional de Competències d'Empleabilitat per a joves de 12 a 18 anysEls resultats que s'obtenen en aquest test serveixen per reflexionar sobre el desenvolupament de les competències d'empleabilitat.
Sala Roca, Josefina   +4 more
core   +1 more source

Didàctica humanista al segle XXI

open access: yesRevista Catalana de Pedagogia, 2016
Té sentit parlar de didàctica humanista en ple segle XXI? Creiem que sí, si els objectius valuosos que es pretenen són favorables a la persona i promouen una educació integral. Hi ha una sola metodologia de treball per aconseguir l’aprenentatge?
Joan Mallart i Navarra
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Introducció a l'organització administrativa, òrgans i competències

open access: yes, 2022
Apunts sobre l'organització administrativa, els òrgans i les ...
Milian i Massana, Antoni
core   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Competències mediàtiques a l’IES Dr. Balmis d’Alacant

open access: yesÍtaca, 2013
La introducció de les TIC en l’ensenyament (les TAC) planteja molts interrogants entre els membres de la comunitat educativa, especialment entre el professorat.
Josep Manuel Escolano i López
doaj   +1 more source

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