Results 51 to 60 of about 151,430 (244)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Skills and Profile of the New Role of the Translator as MT Post-editor [PDF]

, 2012
This paper explores the skills and profile of the new role of the translator as MT post-editor in view of the rising interest and use of MT in the translation industry.
Rico Pérez, Celia, Torrejón, Enrique
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

El blindatge de les competències i la reforma estatutària

Revista Catalana de Dret Públic, 2005
L’experiència del desenvolupament de l’autonomia al llarg dels darrers 25 anys mostra una reducció notable de les competències de la Generalitat respecte de les expectatives inicials i un procés persistent d’erosió, per diverses vies, que ha limitat la ...
Enoch Albertí Rovira
doaj  

L'estudi d'ocupadors: anàlisi qualitativa : l'opinió dels ocupadors sobre els graduats en infermeria [PDF]

, 2016
Aquest informe és resultat de la fase qualitativa del projecte Ocupadors, dissenyat i dirigit per l'Agència per a la Qualitat del Sistema Universitari de Catalunya (AQU Catalunya) i que s'ha dut a terme gràcies a la col·laboració de l'Obra Social "la ...
Agència per a la Qualitat del Sistema Universitari de Catalunya, Barranco Font, Oriol, Universitat Autònoma de Barcelona. Centre d'Estudis Sociològics sobre la Vida Quotidiana i el Treball, Verd Pericàs, Joan Miquel   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Competències mediàtiques a l’IES Dr. Balmis d’Alacant

Ítaca, 2013
La introducció de les TIC en l’ensenyament (les TAC) planteja molts interrogants entre els membres de la comunitat educativa, especialment entre el professorat.
Josep Manuel Escolano i López
doaj   +1 more source

Integració de competències genèriques a les titulacions de Grau de l’Escola d'Enginyeria de Terrassa (EET) a través de les TIC: comunicació eficaç oral i escrita, tercera llengua i treball en grup [PDF]

, 2013
S'ha equipat una sala de la Biblioteca del Campus de Terrassa, BCT, com a estudi d'enregistrament de vídeos. Els estudiants poden reservar anticipadament una sessió d'enregistrament mitjançant una plataforma digital i, en aquest estudi, poden gravar ...
Arias Pujol, Antoni, Hervada Sala, Carme, Jaen Fernandez, Carles, Masip Álvarez, Albert, Nejjari Akhi-Elarab, Fatiha, Pàmies Gómez, Teresa, Rodríguez Sorigué, María Cristina, Romero Durán, David, Álvarez del Castillo, Ma. Dolores   +8 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source