Results 71 to 80 of about 29,264,869 (300)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Competence Based Taxonomy of Automotive Supplier Firms ----- Its title in Hungarian: Autóipari beszállító vállalatok kompetencia alapú taxonómiája [PDF]

, 2008
: The aim of the paper is to develop a competence-based taxonomy of supplier firms of the automotive industry. Two different theories, the resource based theory of the firm and the customer value approach, are linked and applied in order to develop this ...
Gelei, Andrea
core   +1 more source

COMPETENCE APPROACH AND PRACTICE-BASED LEARNING

Высшее образование в России, 2016
Currently, there is a set of processes related to significant changes in contemporary Russian system of higher education. This article focuses on the experience of practice-based learning implementation in higher education.
Alexander V. Mamatov, Alexander N. Nemtsev, Julia M. Mel'nik, Oksana Yu. Zhidkikh, Marina A. Bondareva   +4 more
doaj  

Matter of competency-based approach

Высшее образование в России, 2022
In the article it is shown that the orientation towards competences, which forms the basis of higher professional education reforming through the introduction of the new standards, rests on the mixture of two fundamentally different approaches. This results in the extremely poor quality standards and matrixes of correspondences, and does not lead to ...
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Toward Competence: An Eclectic Approach

, 1982
Recent interest in children's rights has led to a rejection of the presumption of total incompetency of minors prior to the legal age of majority. Colburn-Rohn, an educational consultant, cites authorities in several disciplines to develop a model for ...
Colburn-Rohn, Ellen
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Competence approach to social rehabilitation of deviant adolescents in special institutions

Психология и право, 2013
We describe the informative aspect of social rehabilitation deviant of adolescents in special institutions, the necessity of considering the competence approach as a conceptual, methodological basis of the special institution activities.
Melnikova M.L.
doaj  

Ontological approach for competency-based curriculum analysis

Heliyon
This article is dedicated to the development of a model for competencies within an educational program and its implementation through the use of semantic technologies. The model proposed by the authors is distinctive in that competencies are organized into a hierarchical data structure with arbitrary levels of nesting. Furthermore, the article presents
Marek Milosz, Aizhan Nazyrova, Assel Mukanova, Gulmira Bekmanova, Dmitrii Kuzin, Gaukhar Aimicheva   +5 more
openaire   +3 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source