Results 61 to 70 of about 190,632 (269)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

COMPETENCE APPROACH AND PRACTICE-BASED LEARNING

Высшее образование в России, 2016
Currently, there is a set of processes related to significant changes in contemporary Russian system of higher education. This article focuses on the experience of practice-based learning implementation in higher education.
Alexander V. Mamatov, Alexander N. Nemtsev, Julia M. Mel'nik, Oksana Yu. Zhidkikh, Marina A. Bondareva   +4 more
doaj  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Competence approach to social rehabilitation of deviant adolescents in special institutions

Психология и право, 2013
We describe the informative aspect of social rehabilitation deviant of adolescents in special institutions, the necessity of considering the competence approach as a conceptual, methodological basis of the special institution activities.
Melnikova M.L.
doaj  

Ontological approach for competency-based curriculum analysis

Heliyon
This article is dedicated to the development of a model for competencies within an educational program and its implementation through the use of semantic technologies. The model proposed by the authors is distinctive in that competencies are organized into a hierarchical data structure with arbitrary levels of nesting. Furthermore, the article presents
Marek Milosz, Aizhan Nazyrova, Assel Mukanova, Gulmira Bekmanova, Dmitrii Kuzin, Gaukhar Aimicheva   +5 more
openaire   +3 more sources

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Innovation and development prospects of pre-university education of Saratov State Medical University [PDF]

Саратовский научно-медицинский журнал, 2011
The article considers innovative methods used in the pre-university education at Saratov State Medical University and directed to the modernization of educational program.
Popkov V.M., Protopopov A. A., Fedorova L.M., Naumova E.V.   +3 more
doaj  

SPECIFICS OF ELABORATING METHODOLOGY TO TEACH INNOVATIVE COMPETENCE USING EMBEDDABLE MODULE

Интеграция образования, 2016
Introduction: the article is concerned with the development of competence when teaching students innovative activity. The analysis of bachelor’s degree programmes in engineering and technology demonstrates the absence of competencies for innovation ...
Nikolai I. Naumkin, Elena P. Grosheva , Galina A. Kondratyeva, Elena N. Panyushkina , Vladimir F. Kupryashkin   +4 more
doaj   +1 more source