Results 51 to 60 of about 11,455,528 (298)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Professional Training of Future Masters of Primary Education to Innovative Activities Through the Prism of a Competence Approach

Journal of Vasyl Stefanyk Precarpathian National University, 2020
The current problems of the advanced system, which were most often used by masters who were studying for innovation, are updated. Theoretical analysis of scientific sources with understanding of the concept of “personal approach” is carried out.
Oksana Tsiuniak
doaj   +1 more source

The Competence Approach and Its Literary Educational Projections in the First High School Stage

, 2020
In line with the current educational theses, this publication recognizes the role of competency approach in the contemporary literary education, focusing on the literary educational discourse in the first high school stage (grades 8-10).
Ekaterina Petkova
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Formation of non-linguistic competencies in teaching latin

Развитие образования
The methodology of teaching Latin has undergone significant changes in recent years, and traditional approaches do not produce high-quality results. Therefore, the search for new effective methods of teaching this discipline becomes relevant.
Natalya Y. Sivkina, Irina Y. Vashcheva
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Сurricula plans: competence approach

Polylinguality and Transcultural Practices, 2009
The article focuses on curricula plans and students' role while the principle of complexity and aspect teaching to improve quality of teaching Russian for Foreigners at pre Bachelor's level is put into practice.
T V Shoustikova
doaj  

Transformation of Environmental Bacillus subtilis Isolates by Transiently Inducing Genetic Competence [PDF]

, 2010
Domesticated laboratory strains of Bacillus subtilis readily take up and integrate exogenous DNA. In contrast, ‘‘wild’’ ancestors or Bacillus strains recently isolated from the environment can only be genetically modified by phage transduction ...
Nijland, Reindert,, Veening, Jan Willem, Errington, Jeff,, J. Grant Burgess, Burgess, Grant J., J Grant Burgess, Burgess, J. Grant, Reindert Nijland, Veening, Jan-Willem,, Jan-Willem Veening, Nijland, Reindert, Burgess, J. Grant,, Errington, Jeff, Jeff Errington, Veening, Jan-Willem   +14 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source