Results 191 to 200 of about 99,323 (301)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery

Angewandte Chemie, EarlyView.
We report a stapled glucagon‐like peptide‐1 (GLP‐1) analogue created via multicomponent tryptophan‐mediated Petasis reaction (TMPR). This strategy yields a stabilised peptide with superior helicity and improved potency. Conjugation to a bromodomain‐containing protein 4 (BRD4) degrader creates the first GLP‐1‐guided targeted protein degrader (PROTAC ...
Jan L. Venne, Sona Krajcovicova, Graeme Davies, Hannah Bolt, Jefferson Revell, David R. Spring   +5 more
wiley   +2 more sources

Nurse Managers' Awareness of and Competence in Palliative Care in Municipal Care Settings: A Systematic Mixed Studies Review. [PDF]

Nurs Health Sci
Xu H, Möllerberg ML, Dalhammar K, Bengtsson M, Sjögren Forss K.   +4 more
europepmc   +1 more source

Why do I use generative artificial intelligence (GenAI) to seek health information? A perceptual perspective of GenAI users. [PDF]

Front Public Health
Zhu H, Ding J.
europepmc   +1 more source

'They Absolutely Love It, or They're Terrified of It'. The Self-Perceived Competence of Australian Speech-Language Pathologists in Augmentative and Alternative Communication. [PDF]

Int J Lang Commun Disord
Conlon C, Preston R, Zupan B.
europepmc   +1 more source

CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. [PDF]

EMBO Mol Med
Wang W, Pan Z, Jing H, Shi R, Wu L, Wang J, Chen B, Mu J, Zhang Z, Wu T, Li Q, Shi J, Kuang Y, He L, Wang L, Sang Q.   +15 more
europepmc   +1 more source

The relationship between professional competence and work engagement among Chinese biomedical laboratory technicians: a moderated mediation model. [PDF]

BMC Psychol
Chen R, Ming D, Fan C, Zhao M.
europepmc   +1 more source

Dynamic pathways in the development of university students' AI literacy: integrating quantitative and qualitative evidence. [PDF]

Front Psychol
ZhuGe Z, Li C.
europepmc   +1 more source

Questionnaire responses dataset on scientific literacy as a global citizenship-related competence among preservice teachers in Vietnam. [PDF]

Data Brief
Dang UP, Lai LP, Pham QV.
europepmc   +1 more source

Molecular Dioxygen‐Mediated Passivation of Electron Traps in n‐Type Organic Charge‐Transfer Complexes

Angewandte Chemie International Edition, EarlyView.
O2 enhances charge‐transfer in n‐type organic donor–acceptor charge‐transfer complexes (CTCs) via physisorption‐mediated trap passivation. By suppressing recombination and promoting long‐lived delocalized charge carriers, O2 improves electron transport and conductivity without doping.
Kirill K. Gubanov, Yana Reva, Christian L. Ritterhoff, Fabio Candolfi, Daniel Langford, Maximilian Herm, Evanie Franz, Ryan W. Crisp, Frank Hampel, Michael Krieger, Andreas Späth, Benjamin Watts, Jörg Libuda, Heiko B. Weber, Bernd Meyer, Dirk M. Guldi, Rainer H. Fink   +16 more
wiley   +1 more source