Results 61 to 70 of about 1,304,895 (387)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Pengaruh Kompetensi Sumber Daya Manusia, Teknologi Informasi, Reviu Laporan Keuangan dan Sistem Pengendalian Internal terhadap Kualitas Laporan Keuangan pada Pemerintah Provinsi Sulawesi Utara [PDF]

, 2016
This study aims to examine the effect of human resources competence, information technology, review of financial statement and internal control system on the quality of financial statement in Government of North Sulawesi.
Ilat, V. (Ventje), Kalumata, M. C. (Merlyn), Warongan, J. D. (Jessy)   +2 more
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Human Resources Development Model For The Industrial Revolution 4.0 Era In Aceh, Indonesia

, 2021
This study aims to identify the competencies and to develop a human resource development model for industry 4.0 in Aceh. To achieve the objectives, the study used a mixed-method research approach.
Zahri Hamat Et al. Fairuzzabadi
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

The Management of Elaborating the Program for University Studies With License Exam for The Economic Engineering Specialization [PDF]

Journal of Electrical and Electronics Engineering, 2009
Given the current socio-economic contextand the needs for long-term development in Romania,The National Strategic Reference Framework has asgeneral objective the employment of educationalmeans with the aim of reducing the economic andsocial discrepancies
L.D. Măgdoiu, I. C. Rada, A. Păcală, V.S. Abrudan Caciora   +3 more
doaj  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Kinerja Pegawai Ditinjau Dari Kompetensi, Kompensasi, Motivasi Kerja, dan Disiplin Kerja

Jurnal Manajemen Stratejik dan Simulasi Bisnis, 2023
The success of the hospital in providing the best and quality service to the community can be measured by the quality of the performance of its human resources.
Yenni Rosyinah Hasibuan, Fitria Ridha Ningsih, Yuliarni Putri   +2 more
doaj   +1 more source

Investing in Human Resource Planning: An International Study [PDF]

, 2010
In this paper we study drivers of firms’ human resource planning practices. This is done by analyzing two central parts of personnel planning, formal HRM strategies and analyses of competence development needs.
Døving, Erik, Nordhaug, Odd
core   +3 more sources

Competencies For Human Resource Development Practitioners

International Business & Economics Research Journal (IBER), 2010
This paper reports on research into the required competencies of human resource development practitioners (HRD) in selected South African organizations.  The research identified the level of importance and of satisfaction with the main competencies amongst HRD practitioners. Data was gathered from a random sample of business establishments.
Erasmus, B.J., Loedolff, P.v.Z, Hammann, F.   +2 more
openaire   +2 more sources