Results 41 to 50 of about 526,862 (304)

Hire Education: Mastery, Modularization and the Workforce Revolution [PDF]

, 2014
This new research identifies online competency-based learning as the solution to shifting demands for specialized workforce skills and the front runner for disrupting higher ...
Clayton M. Christensen, Michelle R. Weise   +1 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Competency-based medical education for Indian undergraduates: Where do we stand?

APIK Journal of Internal Medicine
The traditional system of medical education was a structure and process-based system with limited assessment of application of knowledge, skills, and attitudes.
Mamta Gehlawat, Goutham Thumati, Priyanka Samala, Chaganti Lalitha Alekhya, Are Shailaja, Anamika Sharma   +5 more
doaj   +1 more source

Impact of faculty development in curriculum implementation support program (CISP II) training on execution of competency-based medical education

Kanem Journal of Medical Sciences, 2023
Background: Medical education in our country has so far been commendable and comparable with international standards in terms of educating a competent medical practitioner.
Suma S, Suresh I Kumar, Abeetha S, Chitra M, Hari V Prasad   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Competency Education Series: Policy Brief One, An Emerging Federal Role for Competency Education [PDF]

, 2013
After two decades of standards-based reform, a new education paradigm has begun to take hold -- the rise of competency education. This new vision builds on the strong foundation of new college and career ready standards, challenging stakeholders to ...

core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Milestones and Competency-Based Medical Education [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī
Dear Editor Competency-Based Medical Education (CBME) in medical education is defined as “an outcomes-based approach to the design, implementation, assessment, and evaluation of medical education programs using a competency-based organizational ...
Hamid Mahdavifard
doaj  

The Question of Competence: Reconsidering Medical Education in the Twenty-First Century [PDF]

, 2013
[Excerpt] The real challenge for those involved in designing competency-based educational programs is to recognize the complexity of competence as a concept. Only then can they effectively delineate the knowledge, skills, and attitudes that learners must
Hodges, Brian D, Lingard, Lorelei
core   +1 more source