Results 51 to 60 of about 28,432,988 (289)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Clinical Competency‐Centered Learning Outcomes in Basic Medical Education [PDF]

, 2016
Outcome-based learning is a global trend in medical education. The Korean Association of Medical Colleges (KAMC) has been developing learning objectives for basic medical education (BME) in Korea.
연세대학교 의과대학
core   +1 more source

Operationalizing Competency-based Medical Education Within Clinical Competency Committees

Western Journal of Emergency Medicine
This scholarly perspective explores the integration of competency-based medical education (CBME) within graduate medical education assessment systems, specifically the clinical competency committee (CCC).
Andrew Golden, Sara Dimeo, Caroline Molins, Paul Kukulski, Kaitlin Ray, Benjamin Schnapp, Laura Hopson   +6 more
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Matrizes para a Aquisição de Competências no Ensino de Urgências Clínicas / Ensino de Urgências Orientado por Competências

Revista Brasileira de Educação Médica
RESUMO A Faculdade de Ciências Médicas e da Saúde (FCMS) da PUC-SP, campus Sorocaba, inseriu o aluno do internato em uma Unidade de Pronto Atendimento no estágio de urgências clínicas com os objetivos de melhorar o processo de ensino-aprendizagem em ...
Maria Helena Senger, Maria Celeste Gonçalves Campos   +1 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Medical Education in the Gulf Cooperation Council: A Saudi Arabia Anchored Analysis from Expansion to System Alignment [PDF]

Journal of Advances in Medical Education and Professionalism
Introduction: Medical education in the Gulf Cooperation Council (GCC) has undergone substantial transformation over the past two decades, driven by health system reform, workforce localization,and increasing demand for quality and accountability.
MOHAMMAD MUZAFFAR MIR, AHMAD HAMOUD AL-HAZMI, ALSALEEM MOHAMMED ABADI, ABDULLAH M. AL-SHAHRANI, MUSHABAB ALGHAMDI, MOHANNAD MOHAMMAD S. ALAMRI, AHMED YAHIA AL AMEER, SABA MUZAFFAR MIR, MOHAMMED JEELANI, JUNAID AHMAD, MOHAMMED OHAJ   +10 more
doaj   +1 more source