Results 61 to 70 of about 28,432,988 (289)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Competency-Based Medical Education at Scale: A Road Map for Transforming National Systems of Postgraduate Medical Education

Perspectives on Medical Education
In the past decade, the Canadian system of postgraduate medical education has been transformed with the implementation of a new approach to competency based medical education called Competence by Design.
Jolanta Karpinski, Jennifer Stewart, Anna Oswald, Timothy R. Dalseg, Adelle Atkinson, Jason R. Frank   +5 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Enabling Implementation of Competency Based Medical Education through an Outcomes-Focused Accreditation System

Perspectives on Medical Education
Competency based medical education is being adopted around the world. Accreditation plays a vital role as an enabler in the adoption and implementation of competency based medical education, but little has been published about how the design of an ...
Timothy R. Dalseg, Brent Thoma, Keith Wycliffe-Jones, Jason R. Frank, Sarah Taber   +4 more
doaj   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Research on the effect of professional competency of college physical education teachers on students’ motivation for physical education learning

Frontiers in Psychology
IntroductionThis study, based on self-determination theory, constructs a multilevel model to examine the impact of the professional competency of college physical education teachers (PCCPET) on students’ motivation for physical education learning (SMPEL).
Wanhong Luo, Xu Sun, Zongkai Zhou, Zuguo Tian, Zichao Chen   +4 more
doaj   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Competency-Based Education in Three Pilot Programs

, 2014
Competency-based education meets students where they are academically, provides students with opportunities for choice, and awards credit for evidence of learning, not for the time students spend studying a subject.
Rudnick, Mollie, Santibanez, Lucrecia, Faxon-Mills, Susannah, Lewis, Matthew W., Steele, Jennifer L.   +4 more
core   +1 more source

A Competence-based System for Recommending Study Materials from the Web (CBSR) [PDF]

, 2010
A pedagogically-informed approach to the design of an e-learning system is important since an effective learning system requires teaching activities that match the students’ learning requirements.
Lester Gilbert, Gary B Wills, Gilbert, Lester, Wills, Gary, Nitchot, Athitaya, Athitaya Nitchot   +5 more
core   +2 more sources

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source