Results 31 to 40 of about 17,117 (263)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Integration of an ontological model of CDIO competencies into the design of educational programs: transforming educational projects into knowledge content

Frontiers in Computer Science
The Conceive–Design–Implement–Operate (CDIO) Syllabus expresses graduate competencies in natural language developed through project-based learning, yet the link between declared competencies and delivered content is maintained manually.
Yenglik Kadyr, Bulat Kubekov, Aislu Kassekeyeva, Rakhila Turebayeva, Aizhan Nazyrova, Zhanar Lamasheva, Ainur Shekerbek   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Hospitality, tourism, and events industry competency model: Human resource management implications

Zeszyty Naukowe Małopolskiej Wyższej Szkoły Ekonomicznej w Tarnowie, 2019
This paper addresses the implications of hospitality, tourism and events industry competency modeling on human resource management for organizations and employees.
Barry A. Friedman
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Modeling Human Morphological Competence [PDF]

Frontiers in Psychology, 2020
One of the central debates in the cognitive science of language has revolved around the nature of human linguistic competence. Whether syntactic competence should be characterized by abstract hierarchical structures or reduced to surface linear strings has been actively debated, but the nature of morphological competence has been insufficiently ...
Yohei Oseki, Yohei Oseki, Alec Marantz, Alec Marantz, Alec Marantz   +4 more
openaire   +3 more sources

Assessment of mathematical modeling competency among undergraduates in Hebei province

Infinity
Mathematical modeling competency, a key skill for applying mathematical knowledge to solve real-world problems, has gained increasing attention across various fields. Research indicates that students' mathematical modeling competencies are generally low.
Shuxian Zheng, Kwan Eu Leong
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A Systematic Review of Evidence-based General Competency Models: Development of a General Competencies Taxonomy

Journal of Work and Organizational Psychology
The purpose of this research was to develop a taxonomy of competencies common across different jobs, occupations, and organizations. To achieve this objective, a definition of competency was constructed and a systematic literature review was conducted ...
David Arribas-Aguila, Gloria Castaño, Rosario Martínez-Arias   +2 more
doaj   +1 more source

Analyzing student response processes to refine and validate a competency model and competency-based assessment task types

Frontiers in Education
Regarding competency-oriented teaching in higher education, lecturers face the challenge of employing aligned task material to develop the intended competencies.
Chantal Soyka, Niclas Schaper
doaj   +1 more source