Results 41 to 50 of about 17,117 (263)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Competing Risks and Multistate Models [PDF]

Clinical Cancer Research, 2013
Abstract Complex clinical endpoints are present in studies in cancer. Especially in studies on hematopoietic stem-cell transplantation (HSCT), various risks exist after HSCT. Patients can experience acute and chronic graft versus host disease (GVHD) or need to undergo immunosuppressive therapy (IST), a relapse can occur, or patients ...
Schmoor, Claudia, Schumacher, Martin, Finke, Jürgen, Beyersmann, Jan   +3 more
openaire   +3 more sources

Wind Shear Operation-Based Competency Assessment Model for Civil Aviation Pilots

Aerospace
Undesirable meteorological conditions are typical aviation flight safety threats. Although most meteorological radar and flight augmentation computers have avionic system wind shear alarms, the preferred approach is that pilots avoid unsafe wind shear ...
Fan Li, Xuezhi Xu, Jiayuan Li, Huiyun Hu, Mingda Zhao, Hong Sun   +5 more
doaj   +1 more source

An Ontology Based Approach for Modeling and Managing the Profiles and Competencies in Virtual Organization Breeding Environment [PDF]

Journal of Information Technology Management, 2011
In this article, the ontology based approach for modeling and management of profiles and competencies in virtual organization breeding environment (VBE) is presented.
Shohreh Mehrasa, ali moeini, Kambiz Badie, Abbas Asosheh   +3 more
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

A Competence Model for Environmental Education [PDF]

Environment and Behavior, 2013
The goal of environmental education is ultimately to enable a person to strive for and to attain a more ecological way of life. In this article, we begin by distinguishing three forms of environmental knowledge and go on to predict that people’s attitude toward nature represents the force that drives their ecological behavioral engagement.
Nina Roczen, Florian G. Kaiser, Franz X. Bogner, Mark Wilson   +3 more
openaire   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

GNN-driven modeling and prediction of multi-dimensional correlation of international medical education quality based on competence

Computers and Education: Artificial Intelligence
This study addresses the challenge of modeling competency-based international medical education (IME) quality, where traditional methods struggle with heterogeneous multi-dimensional indicators and temporal dynamics.
Ailing Yang, Ling Lin, Hu Zhang, Rong Su, Yunfei Li   +4 more
doaj   +1 more source