Results 161 to 170 of about 83,602 (280)

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

The lncRNA myocardial infarction associated transcript-centric competing endogenous RNA network in non-small-cell lung cancer [PDF]

, 2018
Chang Zheng,1,2 Xuelian Li,2 Biyun Qian,3 Nannan Feng,3 Sumeng Gao,3 Yuxia Zhao,4 Baosen Zhou1,2 1Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Affiliated Hospital, China Medical University, Shenyang 110001, People ...
Feng N, Li X, Zhou B, Zheng C, Qian B, Gao S, Zhao Y   +6 more
core  

Molecular mechanism underlying the protective effects of ischemic preconditioning in total knee arthroplasty

Chinese Journal of Traumatology
Propose: To investigate the molecular mechanisms underlying the protective effects of ischemic preconditioning (IPC) in patients undergoing total knee arthroplasty.
Yongli Wang, Bencai Du, Xueliang Han, Lianjun Qu   +3 more
doaj   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Construction and function analysis of the LncRNA-miRNA-mRNA competing endogenous RNA network in autoimmune hepatitis. [PDF]

BMC Med Genomics, 2022
Li Z, Liu Y, Hou Y, Li Z, Chen C, Hao H, Liu Y.   +6 more
europepmc   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets

Cell Death & Disease
AbstractAs a newly identified regulated cell death, ferroptosis is a metabolically driven process that relies on iron and is associated with polyunsaturated fatty acyl peroxidation, elevated levels of reactive oxygen species (ROS), and mitochondrial damage. This distinct regulated cell death is dysregulated in various cancers; activating ferroptosis in
Fatemeh Nejadi Orang, Mahdi Abdoli Shadbad   +1 more
openaire   +3 more sources

Reconstruction and analysis of potential biomarkers for hypertrophic cardiomyopathy based on a competing endogenous RNA network. [PDF]

BMC Cardiovasc Disord, 2022
Chen JY, Xie ZX, Dai JZ, Han JY, Wang K, Lu LH, Jin JJ, Xue SJ.   +7 more
europepmc   +1 more source

Ovarian Cancer Diagnosis and Chemoresistance Prediction Model Based on cfRNA Molecular Signature

Advanced Science, EarlyView.
A deep learning model analyzes cfRNA profiles extracted from the blood of OVCA patients. This innovative approach distinguishes OVCA from healthy controls with high accuracy. Crucially, it reliably predicts patient response to chemotherapy (sensitive versus resistant subgroups).
Qinhao Guo, Yangyang Zhang, Yongcheng Jin, Siwei Deng, Yongqi Chen, Zheng Feng, Hao Wen, Liu Wang, Yilin Li, Fanghong Ou, Yong Shen, Haiming Li, Tianyao Zhou, Xingzhu Ju, Xiaohua Wu   +14 more
wiley   +1 more source

Delineation of a SMARCA4-specific competing endogenous RNA network and its function in hepatocellular carcinoma. [PDF]

World J Clin Cases, 2022
Zhang L, Sun T, Wu XY, Fei FM, Gao ZZ.
europepmc   +1 more source