Results 1 to 10 of about 4,583,316 (255)

Construction of a lncRNA-associated competing endogenous RNA regulatory network after traumatic brain injury in mouse

Molecular Brain, 2022
Traumatic brain injury (TBI) is a major public health problem worldwide which causes high mortality and disability. Functioning as microRNA (miRNA) sponges, long non-coding RNA (lncRNA) regulates the expression of protein-coding genes in a competing ...
Siqi Wang, Yiyu Sun, Shaobo Hu, Cen Lou, Yuan-Bo Pan   +4 more
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Comprehensive analysis of ceRNA network related to lincRNA in glioblastoma and prediction of clinical prognosis

BMC Cancer, 2021
Background Long intergenic non-coding RNAs (lincRNAs) are capable of regulating several tumours, while competitive endogenous RNA (ceRNA) networks are of great significance in revealing the biological mechanism of tumours.
Guangdong Liu, Danian Liu, Jingjing Huang, Jianxin Li, Chuang Wang, Guangyao Liu, Shiqiang Ge, Haidong Gong   +7 more
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Reconstruction of the lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveals functional miRNAs and lncRNAs in burns and keloids.

PLoS ONE
BackgroundsLong non-coding RNAs (lncRNAs) exert their pharmacological functions by serving as sponges for related microRNAs (miRNAs), thereby modulating gene expression.
Yueru Wang, Zhichao Wang, Jiaojiao Pan, He Wang, Ziwen Lei, Jing Liu, Junbo Zou, Haizhen Lv, Fei Luan   +8 more
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Comprehensive analysis of the FOXA1-related ceRNA network and identification of the MAGI2-AS3/DUSP2 axis as a prognostic biomarker in prostate cancer

Frontiers in Oncology, 2023
BackgroundProstate cancer (PCa) is the second most common cause of cancer-related deaths in American men. Even though increasing evidence has disclosed the competitive endogenous RNA (ceRNA) regulatory networks among cancers, the complexity and behavior ...
Guo Yang, Xiong Chen, Zhen Quan, Miao Liu, Yuan Guo, Yangbin Tang, Lang Peng, Leilei Wang, Yingying Wu, Xiaohou Wu, Jiayu Liu, Yongbo Zheng   +11 more
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Comprehensive characterization of the competitive endogenous RNA network revealing its immune-related functions in hepatic ischemia-reperfusion injury.

PLoS ONE
Hepatic ischemia-reperfusion injury (HIRI) is a common complication in liver surgery and transplantation. Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) network in HIRI.
Lirong Liu, Qi Wang, Shuang Qin, Chang Su, Xin Hai, Zhenkuan Yuan   +5 more
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Identification and validation of a novel glycolysis-related ceRNA network for sepsis-induced cardiomyopathy

Frontiers in Medicine
PurposeSepsis-induced cardiomyopathy (SIC) is a major life-threatening condition in critically infected patients. Early diagnosis and intervention are important to improve patient prognosis.
Lulu Cheng, Lulu Cheng, Jiabin Liang, Fangmei Xie, Zeping Han, Wenfeng Luo, Hanwei Chen, Jinhua He   +7 more
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Study of Neuronal Apoptosis ceRNA Network in Hippocampal Sclerosis of Human Temporal Lobe Epilepsy by RNA-Seq

Frontiers in Neuroscience, 2021
Hippocampal sclerosis (HS) is one of the most common pathological type of intractable temporal lobe epilepsy (TLE), often characterized by hippocampal atrophy, neuronal apoptosis, and gliogenesis.
Shengkun Yu, Yifei Gu, Tianyu Wang, Long Mu, Haiyang Wang, Shi Yan, Aoweng Wang, Jiabin Wang, Li Liu, Hong Shen, Meng Na, Zhiguo Lin   +11 more
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Construction of competing endogenous RNA networks from paired RNA-seq data sets by pointwise mutual information

BMC Genomics, 2019
Background A long noncoding RNA (lncRNA) can act as a competing endogenous RNA (ceRNA) to compete with an mRNA for binding to the same miRNA. Such an interplay between the lncRNA, miRNA, and mRNA is called a ceRNA crosstalk. As an miRNA may have multiple
Chaowang Lan, Hui Peng, Gyorgy Hutvagner, Jinyan Li   +3 more
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Identification of lncRNA–miRNA–mRNA regulatory network associated with primary open angle glaucoma

BMC Ophthalmology, 2020
Background Primary open angle glaucoma (POAG) is a multifactorial disorder characterized by a progressive permanent degeneration of retinal ganglion cell (RGCs) death. An increasing number of studies have suggested that long noncoding RNAs (lncRNAs) have
Minwen Zhou, Bing Lu, Wei Tan, Mingshui Fu   +3 more
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Comprehensive analysis of GSEC/miR-101-3p/SNX16/PAPOLG axis in hepatocellular carcinoma.

PLoS ONE, 2022
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies. A growing number of studies have shown that competitive endogenous RNA (ceRNA) regulatory networks might play important roles during HCC process. The present study aimed to identify a
Shangshang Hu, Jinyan Zhang, Guoqing Guo, Li Zhang, Jing Dai, Yu Gao   +5 more
doaj   +1 more source