Results 41 to 50 of about 4,440,633 (238)

Construction and function analysis of the LncRNA-miRNA-mRNA competing endogenous RNA network in autoimmune hepatitis

BMC Medical Genomics, 2022
Research Highlights It was the first time to explore the disorder of ceRNA network involved in the pathogenesis of AIH. The co-expression relationship between the differentially expressed lncRNAs, miRNAs and mRNAs were predicted. The potential biological
Zhencheng Li, Ying Liu, Yiwen Hou, Zhurong Li, Chen Chen, Huiqin Hao, Yang Liu   +6 more
doaj   +1 more source

Development of an Inflammation-Related lncRNA-miRNA-mRNA Network Based on Competing Endogenous RNA in Breast Cancer at Single-Cell Resolution

Frontiers in Cell and Developmental Biology, 2022
The role and mechanism of inflammation in breast cancer is unclear. This study aims to probe the relationship between inflammation and long non-coding RNAs (lncRNAs) and to stablish an inflammation-related competing endogenous RNA (ceRNA) network in ...
Jingxing Liu, Shuyuan Xiao, Jing Chen
doaj   +1 more source

Construction and dissection of the ceRNA‑ceRNA network reveals critical modules in depression

Molecular Medicine Reports, 2019
The prevalence of mental health disorders such as depression is high. Depression is a multifactorial disorder and its underlying mechanisms remain unclear. Competing endogenous RNA (ceRNA) regulation has been reported to serve important roles in human disease.
Lang, Yan, Zhang, Jingchao, Yuan, Zheng
openaire   +3 more sources

Age-related ceRNA networks in adult Drosophila ageing

Frontiers in Genetics, 2023
As Drosophila is an extensively used genetic model system, understanding of its regulatory networks has great significance in revealing the genetic mechanisms of ageing and human diseases. Competing endogenous RNA (ceRNA)-mediated regulation is an important mechanism by which circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) regulate ageing ...
Deying Yang, Deying Yang, Feng Xiao, Jiamei Li, Siqi Wang, Xiaolan Fan, Xiaolan Fan, Qingyong Ni, Qingyong Ni, Yan Li, Yan Li, Mingwang Zhang, Mingwang Zhang, Taiming Yan, Mingyao Yang, Mingyao Yang, Zhi He   +16 more
openaire   +3 more sources

Identification of Potential Signatures and Their Functions for Acute Lymphoblastic Leukemia: A Study Based on the Cancer Genome Atlas

Frontiers in Genetics, 2021
ObjectiveAcute lymphoblastic leukemia (ALL) is a malignant disease most commonly diagnosed in adolescents and young adults. This study aimed to explore potential signatures and their functions for ALL.MethodsDifferentially expressed mRNAs (DEmRNAs) and ...
Weimin Wang, Chunhui Lyu, Fei Wang, Congcong Wang, Feifei Wu, Xue Li, Silin Gan   +6 more
doaj   +1 more source

Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in human aortic dissection

, 2021
Background Many studies on long chain non-coding RNAs (lncRNAs) are published in recent years. But the roles of lncRNAs in aortic dissection (AD) are still unclear and should be further examined.
Panpan Guo, Liu, Qingyang, Xiaotong Song, Zhang, Jian, Guo, Panpan, Han, Yanshuo, Hao Zhang, Tu, Simei, Simei Tu, Fanxing Yin, Zhang, Hao, Yin, Fanxing, Bian, Ce, Ce Bian, Chen Chen, Song, Xiaotong, Chen, Chen, Jian Zhang, Yanshuo Han, Qingyang Liu   +19 more
core   +1 more source

Extensive ceRNA–ceRNA interaction networks mediated by miRNAs regulate development in multiple rhesus tissues [PDF]

Nucleic Acids Research, 2016
Crosstalk between RNAs mediated by shared microRNAs (miRNAs) represents a novel layer of gene regulation, which plays important roles in development. In this study, we analyzed time series expression data for coding genes and long non-coding RNAs (lncRNAs) to identify thousands of interactions among competitive endogenous RNAs (ceRNAs) in four rhesus ...
Xu, Juan, Feng, Lin, Han, Zujing, Li, Yongsheng, Wu, Aiwei, Shao, Tingting, Ding, Na, Li, Lili, Deng, Wei, Di, Xuebing, Wang, Jian, Zhang, Lianfeng, Li, Xia, Zhang, Kaitai, Cheng, Shujun   +14 more
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Chemoresistance Mediated by ceRNA Networks Associated With the PVT1 Locus [PDF]

Frontiers in Oncology, 2019
Competitive endogenous RNA (ceRNA) networks have emerged as critical regulators of carcinogenesis. Their activity is mediated by various non-coding RNAs (ncRNAs), including long non-coding RNAs and microRNAs, which competitively bind to targets, thereby modulating gene expression and activity of proteins.
Olorunseun O. Ogunwobi, Olorunseun O. Ogunwobi, Adithya Kumar   +2 more
openaire   +3 more sources

ceRNA network.

, 2021
(A) An integrative pipeline for transcriptome-wide identification of lincRNA-miRNA-mRNA regulatory networks. Interactions between miRNAs and their targets are predicted using three computational approaches (miRanda, PITA and RNAhybrid). miRNA-lincRNA and
Jiaxing Chen (9107364), Xiaoqin Liu (296429), Zishuai Wang (735976), Lixian Wang (465239), ShuaiCheng Li (5734427), Zhonglin Tang (48165), Guoqiang Yi (489551), Yuwen Liu (1724473), Yalan Yang (735975), Kui Li (48173), Junyu Yan (11191291), Xinhao Fan (11191288), Yongchao Niu (3315834), Longchao Zhang (465233)   +13 more
core   +1 more source

Integrative Clustering Reveals a Novel Subtype of Soft Tissue Sarcoma With Poor Prognosis

Frontiers in Genetics, 2020
BackgroundSoft tissue sarcomas (STSs) are heterogeneous at the clinical and molecular level and need to be further sub-clustered for treatment and prognosis.Materials And MethodsSTSs were sub-clustered based on RNAseq and miRNAseq data extracted from The
Zhenhua Zhu, Zheng Jin, Haibo Zhang, Mei Zhang, Dahui Sun   +4 more
doaj   +1 more source