Results 51 to 60 of about 19,790 (218)
Frontiers in Bioengineering and Biotechnology, 2019 Alzheimer's disease (AD), a degenerative disease of the central nervous system, is the most common form of dementia in old age. The complexity and behavior of circular RNA (circRNA)-associated competing endogenous RNA (ceRNA) network remained poorly ...
Yan Zhang, Fulong Yu, Siqi Bao, Jie Sun
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Frontiers in Cardiovascular Medicine, 2022 BackgroundAccumulated studies have revealed that long non-coding RNAs (lncRNAs) play critical roles in human diseases by acting as competing endogenous RNAs (ceRNAs).
Xiangyu Ke +8 more
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High-throughput validation of ceRNA regulatory networks
BMC Genomics, 2017 Background: MicroRNAs (miRNAs) play multiple roles in tumor biology [1]. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive stoichiometric sequestration [2]. Specifically, computational models predicted [3, 4] and experimental assays confirmed [5, 6] that miRNA activity is dependent on miRNA target
Hua-Sheng Chiu +7 more
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Heliyon, 2022 Background: Hepatitis C virus (HCV) infection contribute to liver fibrosis and cirrhosis, which significantly increases the risk of hepatocellular carcinoma (HCC) development.
Lishi Shao +3 more
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Frontiers in Genetics, 2022 Background: Numerous studies have suggested that programmed cell death (PCD) pathways play vital roles in cerebral ischemia/reperfusion (I/R) injury.
Jun Shu, Lu Yang, Wenshi Wei, Li Zhang
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Tamoxifen resistance-related ceRNA network for breast cancer
Frontiers in Cell and Developmental Biology, 2022 Background: Tamoxifen (TMX) is one of the most widely used drugs to treat breast cancer (BC). However, acquired drug resistance is still a major obstacle to its application, rendering it crucial to explore the mechanisms of TMX resistance in BC. This aims of this study were to identify the mechanisms of TMX resistance and construct ceRNA regulatory ...
Zipeng Qiao +11 more
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BMC Medical Genomics, 2022 Background Being the most common arrhythmia in clinic, atrial fibrillation (AF) causes various comorbidities to patients such as heart failure and stroke.
Xi Chen, Xiang-Yu He, Qing Dan, Yang Li
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Comprehensive analysis of ceRNA network of ERCC4 in colorectal cancer
PeerJ, 2021 Objective ERCC4 is one of the most significant molecules of Nucleotide Excision Repair (NER), which has been researched due to its high expression in colorectal cancer (CRC). This study aimed to find out the ceRNA (competitive endogenous RNA) network of ERCC4 in CRC.
Hu, Huixin +5 more
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Frontiers in Genetics, 2021 AimsActivation of cardiac fibroblasts (CF) is crucial to cardiac fibrosis. We constructed a cardiac fibroblast-related competing endogenous RNA (ceRNA) network.
Qing-Yuan Gao +19 more
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The regulatory mechanism of LncRNA-mediated ceRNA network in osteosarcoma
Scientific Reports, 2022 AbstractAberrantly expressed lncRNAs have been reported to be closely related to the oncogenesis and development of osteosarcoma. However, the role of a dysregulated lncRNA-miRNA-mRNA network in osteosarcoma in the same individual needs to be further investigated. Whole transcriptome sequencing was performed on the tumour tissues and matched paratumour
Chengsen Lin +10 more
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