Results 51 to 60 of about 29,499 (226)

Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks [PDF]

Genome Research, 2014
We introduce a method for simultaneous prediction of microRNA–target interactions and their mediated competitive endogenous RNA (ceRNA) interactions. Using high-throughput validation assays in breast cancer cell lines, we show that our integrative approach significantly improves on microRNA–target prediction accuracy as assessed by both mRNA and ...
Chiu HS, Llobet-Navas D, Yang X, Chung WJ, Ambesi-Impiombato A, Iyer A, Kim HR, Seviour EG, Luo Z, Sehgal V, Moss T, Lu Y, Ram P, Silva J, Mills GB, Califano A, Sumazin P   +16 more
openaire   +3 more sources

Construction of a paclitaxel-related competitive endogenous RNA network and identification of a potential regulatory axis in pancreatic cancer

Translational Oncology, 2022
Background: Increasing numbers of studies have elucidated the role of competitive endogenous RNA (ceRNA) networks in carcinogenesis. However, the potential role of the paclitaxel-related ceRNA network in the innate mechanism and prognosis of pancreatic ...
Si Yuan Lu, Jie Hua, Jiang Liu, Miao Yan Wei, Chen Liang, Qing Cai Meng, Bo Zhang, Xian Jun Yu, Wei Wang, Jin Xu   +9 more
doaj   +1 more source

HumanViCe: host ceRNA network in virus infected cells in human [PDF]

Frontiers in Genetics, 2014
Host-virus interaction via host cellular components has been an important field of research in recent times. RNA interference mediated by short interfering RNAs and microRNAs (miRNA), is a widespread anti-viral defense strategy. Importantly, viruses also encode their own miRNAs.
Suman eGhosal, Shaoli eDas, Rituparno eSen, Jayprokas eChakrabarti, Jayprokas eChakrabarti   +4 more
openaire   +3 more sources

Identification of Long Noncoding RNA Associated ceRNA Networks in Rosacea [PDF]

BioMed Research International, 2020
Rosacea is a chronic and relapsing inflammatory cutaneous disorder with highly variable prevalence worldwide that adversely affects the health of patients and their quality of life. However, the molecular characterization of each rosacea subtype is still unclear.
Lian Wang, Ruifeng Lu, Yujia Wang, Xiaoyun Wang, Dan Hao, Xiang Wen, Yanmei Li, Minghui Zeng, Xian Jiang   +8 more
openaire   +2 more sources

FAM201A, a long noncoding RNA potentially associated with atrial fibrillation identified by ceRNA network analyses and WGCNA

BMC Medical Genomics, 2022
Background Being the most common arrhythmia in clinic, atrial fibrillation (AF) causes various comorbidities to patients such as heart failure and stroke.
Xi Chen, Xiang-Yu He, Qing Dan, Yang Li
doaj   +1 more source

MicroRNAs in age-related diseases [PDF]

, 2013
Aging is a complex process that is linked to an increased incidence of major diseases such as cardiovascular and neurodegenerative disease, but also cancer and immune disorders.
Jazbutyte V, Olivieri F, Pierluigi Nicotera, Stefanie Dimmeler, Yang J   +4 more
core   +1 more source

Circular RNAs and competing endogenous RNA (ceRNA) networks

Translational Cancer Research, 2018
In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance.
Apratim, Mitra, Karl, Pfeifer, Ki-Sun, Park   +2 more
openaire   +2 more sources

Construction and Analysis of a ceRNA Network in Cardiac Fibroblast During Fibrosis Based on in vivo and in vitro Data

Frontiers in Genetics, 2021
AimsActivation of cardiac fibroblasts (CF) is crucial to cardiac fibrosis. We constructed a cardiac fibroblast-related competing endogenous RNA (ceRNA) network.
Qing-Yuan Gao, Qing-Yuan Gao, Hai-Feng Zhang, Hai-Feng Zhang, Zhi-Teng Chen, Zhi-Teng Chen, Yue-Wei Li, Yue-Wei Li, Shao-Hua Wang, Shao-Hua Wang, Zhu-Zhi Wen, Zhu-Zhi Wen, Yong Xie, Yong Xie, Jing-Ting Mai, Jing-Ting Mai, Jing-Feng Wang, Jing-Feng Wang, Yang-Xin Chen, Yang-Xin Chen   +19 more
doaj   +1 more source

Network-based approaches to explore complex biological systems towards network medicine [PDF]

, 2018
Network medicine relies on different types of networks: from the molecular level of protein–protein interactions to gene regulatory network and correlation studies of gene expression.
Conte, Federica, Farina, Lorenzo, Fiscon, Giulia, Paci, Paola   +3 more
core   +1 more source

Construction of ceRNA Network to Reveal Potential Biomarkers in Crohn’s Disease and Validation in a TNBS Induced Mice Model

Journal of Inflammation Research, 2021
Chenglin Ye,1 Sizhe Zhu,2 Jingping Yuan1 1Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Department of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences
Ye C, Zhu S, Yuan J
doaj