Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction [PDF]
Frontiers in Neuroscience, 2022 Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication in elderly patients. Circular RNAs (circRNAs) are abundant in the mammalian brain and can probably regulate cognitive function.
Wei Wang +4 more
doaj +6 more sources
Identification of the specific microRNAs and competitive endogenous RNA mechanisms in osteoporosis [PDF]
Journal of International Medical Research, 2020 Objective Osteoporosis and osteoarthritis are metabolic skeletal disorders. This study aimed to identify specific networks of competitive endogenous RNA (ceRNA) in osteoporosis that differ from those in osteoarthritis.
Junyi Hong +5 more
doaj +4 more sources
Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances [PDF]
Annals of Medicine, 2023 Rheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration.
Jianting Wen +3 more
doaj +2 more sources
Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma [PDF]
Frontiers in Cell and Developmental Biology, 2021 Non-coding RNAs have been shown to play important regulatory roles, notably in cancer development. In this study, we investigated the role of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression
Xiandong Lin +7 more
doaj +3 more sources
Whole-transcriptome analysis of periodontal tissue and construction of immune-related competitive endogenous RNA network [PDF]
BMC Oral Health, 2022 Background In periodontitis, noncoding RNAs may play a regulatory role in the immune microenvironment through competitive endogenous RNA. We aimed to profile noncoding RNA expression and construct immune-related ceRNA network in periodontitis.
Quanquan Zhao +7 more
doaj +2 more sources
Frontiers in Genetics, 2022 Keratoconus (KC) is the most common corneal ectatic disease, with its pathological mechanisms unclear. We mainly performed bioinformatics approaches to reveal core RNA targets and hub competitive endogenous RNA (ceRNA) network and explored the potential ...
Shuai Ouyang +5 more
doaj +3 more sources
miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2 [PDF]
Genetics and Molecular Biology, 2021 MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of ...
Xuesong Yuan +5 more
doaj +1 more source
Advances on the roles of circular RNA in breast cancer [PDF]
Jichu yixue yu linchuang, 2022 Circular RNA (circRNA) is a kind of non-coding RNA with circular structure and is found in a variety of cell types. CircRNA is characterized by diversity, specificity, conservatism and stability.
HE Xiao, HU Wei-jie, LYU Wen-chang, REN Yu-ping, WU Min, WU Yi-ping, ZHANG Qi
doaj +1 more source
Integrated Analysis of ceRNA Network to Reveal Potential Prognostic Biomarkers for Glioblastoma
Frontiers in Genetics, 2022 Glioblastoma (GBM), originating in the brain, is a universally aggressive malignant tumor with a particularly poor prognosis. Therefore, insight into the critical role of underlying genetic mechanisms is essential to developing new therapeutic approaches.
Ruifei Liu +8 more
doaj +1 more source
BMC Cancer, 2020 Background Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to the treatment and prognosis of ...
Junyou Zhu +9 more
doaj +1 more source