Results 1 to 10 of about 110,378 (294)

Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction [PDF]

Frontiers in Neuroscience, 2022
Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication in elderly patients. Circular RNAs (circRNAs) are abundant in the mammalian brain and can probably regulate cognitive function.
Wei Wang, Pengwei Huo, Lei Zhang, Gang Lv, Zhongyuan Xia   +4 more
doaj   +4 more sources

The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis [PDF]

Scientific Reports, 2022
Osteoporosis (OP) is a common bone disease of old age resulting from the imbalance between bone resorption and bone formation. CircRNAs are a class of endogenous non-coding RNAs (ncRNAs) involved in gene regulation and may play important roles in the ...
Hao Li, Changyuan Wang, Yue Jin, Yuanqing Cai, Huijun Sun, Mozhen Liu   +5 more
doaj   +5 more sources

Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke [PDF]

Frontiers in Genetics, 2022
Background: Acute ischemic stroke (AIS) is a severe neurological disease with complex pathophysiology, resulting in the disability and death. The goal of this study is to explore the underlying molecular mechanisms of AIS and search for new potential ...
Zongkai Wu, Zongkai Wu, Wanyi Wei, Hongzhen Fan, Yongsheng Gu, Litao Li, Hebo Wang, Hebo Wang   +7 more
doaj   +4 more sources

Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma [PDF]

Frontiers in Cell and Developmental Biology, 2021
Non-coding RNAs have been shown to play important regulatory roles, notably in cancer development. In this study, we investigated the role of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression
Xiandong Lin, Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang   +7 more
doaj   +3 more sources

Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances [PDF]

Annals of Medicine, 2023
Rheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration.
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang   +3 more
doaj   +2 more sources

Whole-transcriptome analysis of periodontal tissue and construction of immune-related competitive endogenous RNA network [PDF]

BMC Oral Health, 2022
Background In periodontitis, noncoding RNAs may play a regulatory role in the immune microenvironment through competitive endogenous RNA. We aimed to profile noncoding RNA expression and construct immune-related ceRNA network in periodontitis.
Quanquan Zhao, Jing Wen, Xiangying Ouyang, Jianru Liu, Wenyi Liu, Shengnan Zhang, Peiying Lv, Xinzhe Lou   +7 more
doaj   +2 more sources

Identification of the specific microRNAs and competitive endogenous RNA mechanisms in osteoporosis [PDF]

Journal of International Medical Research, 2020
Objective Osteoporosis and osteoarthritis are metabolic skeletal disorders. This study aimed to identify specific networks of competitive endogenous RNA (ceRNA) in osteoporosis that differ from those in osteoarthritis.
Junyi Hong, Fusheng Ye, Binjia Yu, Junwei Gao, Feicheng Qi, Wei Wang   +5 more
doaj   +3 more sources

Kinetic modelling of competition and depletion of shared miRNAs by competing endogenous RNAs [PDF]

, 2018
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended ...
A Arvey, A Baccarini, A Fatica, A Franks, A Helwak, A Joshi, A Loinger, A Martirosyan, A Martirosyan, A Nadal, A Raveh, A Re, A Riba, A Sanchez, A Sanchez-Mejias, AD Bosson, AK Leung, AM Gurtan, AS Flynt, B Du, B Obermayer, C Bosia, C Bosia, C Bosia, CW Hsu, D Baek, D Kim, DP Bartel, DP Bartel, DP Bartel, DT Gillespie, E Anastasiadou, E Berezikov, E Koller, E Levine, E Levine, FA Karreth, G Tkacik, H Liang, H Teimouri, I Alvarez-Garcia, I Bose, I Legnini, J Breda, J Das, J Fiorentino, J Kwon, J Noorbakhsh, J Tsang, JM Franco-Zorrilla, JM Schmiedel, L López-Maury, L Salmena, L Tsimring, M Chekulaeva, M Figliuzzi, M Figliuzzi, M Gerstein, M Jens, M Klein, M Mauri, M Nitzan, M Osella, M Osella, M Samoilov, MA Gibson, MA Valencia-Sanchez, MS Ebert, MS Ebert, NG Kampen Van, P Flondor, P Mehta, P Sumazin, PB Detwiler, PS Swain, R Denzler, R Denzler, RC Brewster, RC Friedman, RI Gregory, S Djuranovic, S Grigolon, S Guil, S Jonas, S Mukherji, S Pitchiaya, S Sass, S Wang, SD Chandradoss, TB Hansen, TR Cech, U Ala, U Alon, V Siciliano, X Lai, X Wang, X Yuan, Y Liang, Y Shimoni, Y Tay, Y Tay, Y Yuan   +101 more
core   +5 more sources

Construction, bioinformatics analysis, and validation of competitive endogenous RNA networks in ulcerative colitis [PDF]

Frontiers in Genetics, 2022
Background: Ulcerative colitis (UC) is a common chronic disease of the digestive system. Recently, competitive endogenous RNAs (ceRNAs) have been increasingly used to reveal key mechanisms for the pathogenesis and treatment of UC.
Longcong Dong, Ruibin Zhang, Qin Huang, Yuan Shen, Hongying Li, Shuguang Yu, Qiaofeng Wu, Qiaofeng Wu   +7 more
doaj   +2 more sources

Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. [PDF]

Cell Cycle
Circular RNA (circRNA) can influence the development of hepatocellular carcinoma (HCC) as a competitive endogenous RNA (ceRNA). However, there are still many circRNAs whose functions are unknown. Our research explores the role of a novel circRNA, hsa_circ_0079875, in HCC.
Liu Y, Luo X, Chen W, Dong Z, Cheng T, Chen L, Ju L, Cai W, Bian Z.   +8 more
europepmc   +3 more sources