Decoding competitive endogenous RNA regulatory network in postoperative cognitive dysfunction [PDF]
Frontiers in Neuroscience, 2022 Postoperative cognitive dysfunction (POCD) is a common postoperative neurological complication in elderly patients. Circular RNAs (circRNAs) are abundant in the mammalian brain and can probably regulate cognitive function.
Wei Wang +4 more
doaj +4 more sources
Long noncoding RNA/circular RNA regulates competitive endogenous RNA networks in rheumatoid arthritis: molecular mechanisms and traditional Chinese medicine therapeutic significances [PDF]
Annals of Medicine, 2023 Rheumatoid arthritis (RA) is a systemic and autoimmune disease that is mainly featured abnormal fibroblast-like synoviocyte (FLS) proliferation and inflammatory cell infiltration.
Jianting Wen +3 more
doaj +2 more sources
Whole-transcriptome analysis of periodontal tissue and construction of immune-related competitive endogenous RNA network [PDF]
BMC Oral Health, 2022 Background In periodontitis, noncoding RNAs may play a regulatory role in the immune microenvironment through competitive endogenous RNA. We aimed to profile noncoding RNA expression and construct immune-related ceRNA network in periodontitis.
Quanquan Zhao +7 more
doaj +2 more sources
The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis [PDF]
Scientific Reports, 2022 Osteoporosis (OP) is a common bone disease of old age resulting from the imbalance between bone resorption and bone formation. CircRNAs are a class of endogenous non-coding RNAs (ncRNAs) involved in gene regulation and may play important roles in the ...
Hao Li +5 more
doaj +2 more sources
Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke [PDF]
Frontiers in Genetics, 2022 Background: Acute ischemic stroke (AIS) is a severe neurological disease with complex pathophysiology, resulting in the disability and death. The goal of this study is to explore the underlying molecular mechanisms of AIS and search for new potential ...
Zongkai Wu +7 more
doaj +2 more sources
Identification of the specific microRNAs and competitive endogenous RNA mechanisms in osteoporosis
Journal of International Medical Research, 2020 Objective Osteoporosis and osteoarthritis are metabolic skeletal disorders. This study aimed to identify specific networks of competitive endogenous RNA (ceRNA) in osteoporosis that differ from those in osteoarthritis.
Junyi Hong +5 more
doaj +2 more sources
Frontiers in Genetics, 2022 Keratoconus (KC) is the most common corneal ectatic disease, with its pathological mechanisms unclear. We mainly performed bioinformatics approaches to reveal core RNA targets and hub competitive endogenous RNA (ceRNA) network and explored the potential ...
Shuai Ouyang +5 more
doaj +3 more sources
Construction, bioinformatics analysis, and validation of competitive endogenous RNA networks in ulcerative colitis [PDF]
Frontiers in Genetics, 2022 Background: Ulcerative colitis (UC) is a common chronic disease of the digestive system. Recently, competitive endogenous RNAs (ceRNAs) have been increasingly used to reveal key mechanisms for the pathogenesis and treatment of UC.
Longcong Dong +7 more
doaj +2 more sources
Exploring Breast Cancer-Associated Genes: A Comprehensive Analysis and Competitive Endogenous RNA Network Construction [PDF]
Archives of Razi InstituteBreast cancer is a cancer affecting women in which cells become abnormal and multiplies in an uncontrollable fashion. These cancers are hereditary and gene mutations with geographic indications stand alone in most invasive breast cancer types, several ...
CharuMeena H +4 more
doaj +2 more sources
Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer’s disease [PDF]
Neural Regeneration ResearchLong noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer’s disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated.
Li Zeng +7 more
doaj +2 more sources