Results 21 to 30 of about 110,378 (294)
BMC Cancer, 2020 Background Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to the treatment and prognosis of ...
Junyou Zhu +9 more
doaj +1 more source
Competitive Endogenous RNAs Cannot Alter MicroRNA Function In Vivo [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
Broderick, Jennifer A +1 more
openaire +3 more sources
Identification of competitive endogenous RNAs network in breast cancer [PDF]
Cancer Medicine, 2019 AbstractBackgroundMiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer.
Xiaojin Wang +7 more
openaire +3 more sources
Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance
European Journal of Medical Research, 2023 Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity
Shuang Qin +3 more
doaj +1 more source
Hsa_circ_0038383-mediated competitive endogenous RNA network in recurrent implantation failure
Aging, 2021 Inadequate endometrial receptivity contributes to recurrent implantation failure (RIF) during IVF-embryo transfer. Though multiple circRNAs have been confirmed differentially expression in RIF, the potential function of novel circRNAs needed to be detected.The top ten DEcircRNAs were selected as initial candidates.
Zhao, Huishan +7 more
openaire +2 more sources
Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis [PDF]
Molecular Biology and Evolution, 2018 The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microRNAs such that the expression level of another target sequence is altered.
Cian Glenfield, Aoife McLysaght
openaire +4 more sources
Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy
Frontiers in Genetics, 2022 Cardiac hypertrophy is an adaptive cardiac response that accommodates the variable hemodynamic demands of the human body during extended periods of preload or afterload increase.
Yang-Hao Chen +7 more
doaj +1 more source
Interaction and cross-talk between non-coding RNAs. [PDF]
, 2017 Non-coding RNA (ncRNA) has been shown to regulate diverse cellular processes and functions through controlling gene expression. Long non-coding RNAs (lncRNAs) act as a competing endogenous RNAs (ceRNAs) where microRNAs (miRNAs) and lncRNAs regulate each ...
Dahiya, Rajvir +3 more
core +2 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Specific binding of the methyl binding domain protein 2 at the BRCA1-NBR2 locus [PDF]
, 1996 The methyl-CpG binding domain (MBD) proteins are key molecules in the interpretation of DNA methylation signals leading to gene silencing. We investigated their binding specificity at the constitutively methylated region of a CpG island containing the ...
Auriol, Emilie +3 more
core +2 more sources