Results 21 to 30 of about 2,278,547 (269)
BMC Genomics, 2018 Background Emerging evidence indicates that Circular RNAs (circRNAs) exert post-transcriptional regulation of gene expression. A subclass of circRNA was found enriched with miRNA target sites. This evidence suggests that this kind of circRNA functions as
Yu-Chen Liu +5 more
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miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2 [PDF]
Genetics and Molecular Biology, 2021 MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of ...
Xuesong Yuan +5 more
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Advances on the roles of circular RNA in breast cancer [PDF]
Jichu yixue yu linchuang, 2022 Circular RNA (circRNA) is a kind of non-coding RNA with circular structure and is found in a variety of cell types. CircRNA is characterized by diversity, specificity, conservatism and stability.
HE Xiao, HU Wei-jie, LYU Wen-chang, REN Yu-ping, WU Min, WU Yi-ping, ZHANG Qi
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Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease [PDF]
Annals of Translational Medicine, 2021 The present study aimed to construct a network of competitive endogenous RNAs (ceRNAs) related to the pathogenesis of coronary artery disease (CAD), to provide a novel rationale for CAD treatment.Bioinformatics methods were applied to screen for differentially expressed long non-coding RNAs (DElncRNAs), microRNAs (DEmiRNAs), and mRNAs (DEmRNAs) from ...
Zuo, Jiebin +4 more
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Integrated Analysis of ceRNA Network to Reveal Potential Prognostic Biomarkers for Glioblastoma
Frontiers in Genetics, 2022 Glioblastoma (GBM), originating in the brain, is a universally aggressive malignant tumor with a particularly poor prognosis. Therefore, insight into the critical role of underlying genetic mechanisms is essential to developing new therapeutic approaches.
Ruifei Liu +8 more
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Comprehensive analysis of competitive endogenous RNA network in colorectal cancer [PDF]
Translational Cancer Research, 2020 Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Growing evidence supports a role for noncoding RNAs (ncRNAs) in CRC. In particular, they form competitive endogenous RNA (ceRNA) networks involved in the regulation of mRNA expression.
Zhang, Meng-Yi, Guo, Bin-Han
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Whole Transcriptome Sequencing Identifies a Competitive Endogenous RNA Network That Regulates the Immunity of Bladder Cancer [PDF]
HeliyonSanhe Liu, Liqun Duan
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BMC Cancer, 2020 Background Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to the treatment and prognosis of ...
Junyou Zhu +9 more
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Identification of competitive endogenous RNAs network in breast cancer [PDF]
Cancer Medicine, 2019 AbstractBackgroundMiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer.
Xiaojin Wang +7 more
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Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis [PDF]
Molecular Biology and Evolution, 2018 The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microRNAs such that the expression level of another target sequence is altered.
Cian Glenfield, Aoife McLysaght
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