Integrated Analysis of ceRNA Network to Reveal Potential Prognostic Biomarkers for Glioblastoma
Frontiers in Genetics, 2022 Glioblastoma (GBM), originating in the brain, is a universally aggressive malignant tumor with a particularly poor prognosis. Therefore, insight into the critical role of underlying genetic mechanisms is essential to developing new therapeutic approaches.
Ruifei Liu +8 more
doaj +1 more source
Comprehensive analysis of competitive endogenous RNA network in colorectal cancer [PDF]
Translational Cancer Research, 2020 Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Growing evidence supports a role for noncoding RNAs (ncRNAs) in CRC. In particular, they form competitive endogenous RNA (ceRNA) networks involved in the regulation of mRNA expression.
Zhang, Meng-Yi, Guo, Bin-Han
openaire +2 more sources
Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network [PDF]
Frontiers in Genetics, 2022 Zhang H +6 more
exaly +2 more sources
BMC Cancer, 2020 Background Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to the treatment and prognosis of ...
Junyou Zhu +9 more
doaj +1 more source
Identification of competitive endogenous RNAs network in breast cancer [PDF]
Cancer Medicine, 2019 AbstractBackgroundMiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer.
Xiaojin Wang +7 more
openaire +3 more sources
Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance
European Journal of Medical Research, 2023 Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity
Shuang Qin +3 more
doaj +1 more source
Competitive endogenous RNA networks: Decoding the role of long non‐coding RNAs and circular RNAs in colorectal cancer chemoresistance [PDF]
Journal of Cellular and Molecular MedicineAli Khalafizadeh
exaly +2 more sources
Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. [PDF]
Cell CycleCircular RNA (circRNA) can influence the development of hepatocellular carcinoma (HCC) as a competitive endogenous RNA (ceRNA). However, there are still many circRNAs whose functions are unknown. Our research explores the role of a novel circRNA, hsa_circ_0079875, in HCC.
Liu Y +8 more
europepmc +3 more sources
Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis [PDF]
Molecular Biology and Evolution, 2018 The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microRNAs such that the expression level of another target sequence is altered.
Cian Glenfield, Aoife McLysaght
openaire +4 more sources
Competitive Endogenous RNAs Cannot Alter MicroRNA Function In Vivo [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
Broderick, Jennifer A +1 more
openaire +3 more sources