Results 21 to 30 of about 56,443 (240)

Comprehensive analysis of competitive endogenous RNA network in colorectal cancer [PDF]

Translational Cancer Research, 2020
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Growing evidence supports a role for noncoding RNAs (ncRNAs) in CRC. In particular, they form competitive endogenous RNA (ceRNA) networks involved in the regulation of mRNA expression.
Zhang, Meng-Yi, Guo, Bin-Han
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Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease [PDF]

Annals of Translational Medicine, 2021
The present study aimed to construct a network of competitive endogenous RNAs (ceRNAs) related to the pathogenesis of coronary artery disease (CAD), to provide a novel rationale for CAD treatment.Bioinformatics methods were applied to screen for differentially expressed long non-coding RNAs (DElncRNAs), microRNAs (DEmiRNAs), and mRNAs (DEmRNAs) from ...
Zuo, Jiebin, Xu, Mengxi, Wang, Danning, Bai, Weizhe, Li, Gang   +4 more
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Identification of competitive endogenous RNAs network in breast cancer [PDF]

Cancer Medicine, 2019
AbstractBackgroundMiRNAs can regulate gene expression directly or indirectly, and long noncoding RNAs as competing endogenous RNA (ceRNAs) can bind to miRNAs competitively and affect mRNA expression. The ceRNA network is still unclear in breast cancer.
Xiaojin Wang, Jiahui Wan, Zhanxiang Xu, Shijun Jiang, Lin Ji, Yutian Liu, Shuwen Zhai, Rongjun Cui   +7 more
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Competitive endogenous network of circRNA, lncRNA, and miRNA in osteosarcoma chemoresistance

European Journal of Medical Research, 2023
Osteosarcoma is the most prevalent and fatal type of bone tumor. Despite advancements in the treatment of other cancers, overall survival rates for patients with osteosarcoma have stagnated over the past four decades Multiple-drug resistance—the capacity
Shuang Qin, Yuting Wang, Chunhui Ma, Qi Lv   +3 more
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Pseudogenes Provide Evolutionary Evidence for the Competitive Endogenous RNA Hypothesis [PDF]

Molecular Biology and Evolution, 2018
The competitive endogenous RNA (ceRNA) hypothesis is an attractively simple model to explain the biological role of many putatively functionless noncoding RNAs. Under this model, there exist transcripts in the cell whose role is to titrate out microRNAs such that the expression level of another target sequence is altered.
Cian Glenfield, Aoife McLysaght
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Competitive Endogenous RNAs Cannot Alter MicroRNA Function In Vivo [PDF]

Molecular Cell, 2014
In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
Broderick, Jennifer A, Zamore, Phillip D.   +1 more
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Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy

Frontiers in Genetics, 2022
Cardiac hypertrophy is an adaptive cardiac response that accommodates the variable hemodynamic demands of the human body during extended periods of preload or afterload increase.
Yang-Hao Chen, Ling-Feng Zhong, Xia Hong, Qian-Li Zhu, Song-Jie Wang, Ji-Bo Han, Wei-Jian Huang, Bo-Zhi Ye   +7 more
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Identification of lncRNA–miRNA–mRNA Networks Linked to Non-small Lung Cancer Resistance to Inhibitors of Epidermal Growth Factor Receptor

Frontiers in Genetics, 2021
Background: Tyrosine kinase inhibitors that act against epidermal growth factor receptor (EGFR) show strong efficacy against non-small cell lung cancer (NSCLC) involving mutated EGFRs.
Ting Wang, Chengliang Yang, Bing Li, Ying Xing, Jian Huang, Yangping Zhang, Shanshan Bu, Hong Ge   +7 more
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Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

Life, 2021
Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack ...
Yubo Shi, Qingyun Huang, Xinyu Kong, Ruichen Zhao, Xinyue Chen, Yujia Zhai, Lixia Xiong   +6 more
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Hsa_circ_0038383-mediated competitive endogenous RNA network in recurrent implantation failure

Aging, 2021
Inadequate endometrial receptivity contributes to recurrent implantation failure (RIF) during IVF-embryo transfer. Though multiple circRNAs have been confirmed differentially expression in RIF, the potential function of novel circRNAs needed to be detected.The top ten DEcircRNAs were selected as initial candidates.
Zhao, Huishan, Chen, Lili, Shan, Yinghua, Chen, Gang, Chu, Yongli, Dai, Huangguan, Liu, Xuemei, Bao, Hongchu   +7 more
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