Results 41 to 50 of about 110,378 (294)

HMGA1pseudogenes as candidate proto-oncogenic competitive endogenous RNAs

Oncotarget, 2014
The High Mobility Group A (HMGA) are nuclear proteins that participate in the organization of nucleoprotein complexes involved in chromatin structure, replication and gene transcription. HMGA overexpression is a feature of human cancer and plays a causal role in cell transformation.
Esposito F, de Martino M, Petti MG, Forzati F, Tornincasa M, Federico A, Arra C, Pierantoni GM, Fusco A   +8 more
openaire   +6 more sources

Regulatory mechanism of circular RNA involvement in osteoarthritis

Frontiers in Surgery, 2023
Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene ...
Yuke Zhang, Liting Liu, Kai Liu, Meiying Wang, Xiulan Su, Jianzhong Wang   +5 more
doaj   +1 more source

Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease [PDF]

Annals of Translational Medicine, 2021
The present study aimed to construct a network of competitive endogenous RNAs (ceRNAs) related to the pathogenesis of coronary artery disease (CAD), to provide a novel rationale for CAD treatment.Bioinformatics methods were applied to screen for differentially expressed long non-coding RNAs (DElncRNAs), microRNAs (DEmiRNAs), and mRNAs (DEmRNAs) from ...
Zuo, Jiebin, Xu, Mengxi, Wang, Danning, Bai, Weizhe, Li, Gang   +4 more
openaire   +2 more sources

Introduction of LPIN1 as a potential diagnostic and prognostic biomarker for gastric cancer via integrative bioinformatics analysis of a competing endogenous RNA network and experimental validation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Identification of effective biomarkers is crucial for the heterogeneous disease of gastric cancer (GC). Recent studies have focused on the role of pseudogenes regulating gene expression through competing endogenous RNA (ceRNA) networks ...
Milad Daneshmand-Parsa, Parvaneh Nikpour
doaj   +1 more source

Non‐coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis

Orthopaedic Surgery, 2021
Objective To investigate the regulatory network of long non‐coding RNA (lncRNA) as competing endogenous RNAs (ceRNAs) in osteonecrosis of the femoral head (ONFH).
Ning Han, Zengchun Li
doaj   +1 more source

Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis

Frontiers in Genetics, 2021
Severe acute pancreatitis (SAP) is an acute digestive system disease with high morbidity mortality and hospitalization rate worldwide, due to various causes and unknown pathogenesis.
Bing Wang, Bing Wang, Jun Wu, Jun Wu, Qilin Huang, Qilin Huang, Xiaohui Yuan, Xiaohui Yuan, Yi Yang, Yi Yang, Wen Jiang, Wen Jiang, Yi Wen, Lijun Tang, Lijun Tang, Hongyu Sun, Hongyu Sun, Hongyu Sun   +17 more
doaj   +1 more source

Comprehensive identification and characterization of lncRNAs and circRNAs reveal potential brown planthopper-responsive ceRNA networks in rice

Frontiers in Plant Science, 2023
Brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most destructive pests of rice. Non-coding RNA plays an important regulatory role in various biological processes.
Yan Wu, Yan Wu, Wenjun Zha, Wenjun Zha, Dongfeng Qiu, Jianping Guo, Gang Liu, Changyan Li, Bian Wu, Sanhe Li, Junxiao Chen, Liang Hu, Shaojie Shi, Lei Zhou, Lei Zhou, Zaijun Zhang, Bo Du, Aiqing You, Aiqing You   +18 more
doaj   +1 more source

A conditional marker gene allowing both positive and negative selection in plants [PDF]

, 2004
Selectable markers enable transgenic plants or cells to be identified after transformation. They can be divided into positive and negative markers conferring a selective advantage or disadvantage, respectively.
Erikson, Oskar, Hertzberg, Magnus, Näsholm, Torgny   +2 more
core   +1 more source

A Potential Competitive Endogenous RNA Pathway Involved in Chronic Spinal Cord Injury [PDF]

Medical Science Monitor, 2018
BACKGROUND Chronic spinal cord injury (CSCI) is a worldwide clinical problem. We aimed to reveal differentially expressed (DE) lncRNAs and to find associated pathways that may function as targets for CSCI therapy. MATERIAL AND METHODS After a CSCI rat model was confirmed by the Basso Beattie Bresnahan (BBB) scale and the Magnetic Resonance Imaging (MRI)
Zhang, Liang, Yang, Li, Li, Wenhui, Yang, Yalin, Sun, Weizong, Gong, Pengfei, Wang, Ling, Wang, Kai   +7 more
openaire   +2 more sources

Role of RNA Interference (RNAi) in the Moss Physcomitrella patens [PDF]

, 2013
RNA interference (RNAi) is a mechanism that regulates genes by either transcriptional (TGS) or posttranscriptional gene silencing (PTGS), required for genome maintenance and proper development of an organism.
Arif, Muhammad Asif, Frank, Wolfgang, Khraiwesh, Basel   +2 more
core   +3 more sources