Results 41 to 50 of about 2,278,547 (269)

Regulatory mechanism of circular RNA involvement in osteoarthritis

Frontiers in Surgery, 2023
Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene ...
Yuke Zhang, Liting Liu, Kai Liu, Meiying Wang, Xiulan Su, Jianzhong Wang   +5 more
doaj   +1 more source

Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis

Frontiers in Genetics, 2021
Severe acute pancreatitis (SAP) is an acute digestive system disease with high morbidity mortality and hospitalization rate worldwide, due to various causes and unknown pathogenesis.
Bing Wang, Bing Wang, Jun Wu, Jun Wu, Qilin Huang, Qilin Huang, Xiaohui Yuan, Xiaohui Yuan, Yi Yang, Yi Yang, Wen Jiang, Wen Jiang, Yi Wen, Lijun Tang, Lijun Tang, Hongyu Sun, Hongyu Sun, Hongyu Sun   +17 more
doaj   +1 more source

Kinetic Modelling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs [PDF]

, 2019
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended and highly heterogeneous miRNA-RNA interaction networks.
Martirosyan, Araks, Del Giudice, Marco, ENRICO BENA, CHIARA, Pagnani, Andrea, Bosia, Carla, De Martino, Andrea   +5 more
openaire   +5 more sources

Comprehensive identification and characterization of lncRNAs and circRNAs reveal potential brown planthopper-responsive ceRNA networks in rice

Frontiers in Plant Science, 2023
Brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most destructive pests of rice. Non-coding RNA plays an important regulatory role in various biological processes.
Yan Wu, Yan Wu, Wenjun Zha, Wenjun Zha, Dongfeng Qiu, Jianping Guo, Gang Liu, Changyan Li, Bian Wu, Sanhe Li, Junxiao Chen, Liang Hu, Shaojie Shi, Lei Zhou, Lei Zhou, Zaijun Zhang, Bo Du, Aiqing You, Aiqing You   +18 more
doaj   +1 more source

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism [PDF]

, 2010
For a long time it has been assumed that the decay of RNA in eukaryotes is mainly carried out by exoribonucleases, which is in contrast to bacteria, where endoribonucleases are well documented to initiate RNA degradation.
Tomecki, Rafał, Dziembowski, Andrzej
core   +3 more sources

Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma [PDF]

Medical Science Monitor, 2019
BACKGROUND Long non-coding RNAs (lncRNAs) affect post-transcriptional regulation by interfering with microRNAs (miRNAs), and by acting as competitive endogenous RNAs (ceRNAs). The roles and mechanisms of lncRNAs as ceRNAs in the progression and prognosis of uterine corpus endometrial carcinoma are not well understood.
Ouyang, Dong, Li, Ruyi, Li, Yaxian, Zhu, Xueqiong   +3 more
openaire   +2 more sources

Non‐coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis

Orthopaedic Surgery, 2021
Objective To investigate the regulatory network of long non‐coding RNA (lncRNA) as competing endogenous RNAs (ceRNAs) in osteonecrosis of the femoral head (ONFH).
Ning Han, Zengchun Li
doaj   +1 more source

Endogenous double-stranded RNA [PDF]

, 2021
\ua9 2021 by the authors. Licensee MDPI, Basel, Switzerland. The birth of long non-coding RNAs (lncRNAs) is closely associated with the presence and activation of repetitive elements in the genome.
Shaymaa Sadeq, Andreas Werner, Al-Hashimi S, Surar Al-Hashimi, Sadeq S, Werner A, Cusack CM, Carmen M. Cusack   +7 more
core   +1 more source

HMGA1pseudogenes as candidate proto-oncogenic competitive endogenous RNAs

Oncotarget, 2014
The High Mobility Group A (HMGA) are nuclear proteins that participate in the organization of nucleoprotein complexes involved in chromatin structure, replication and gene transcription. HMGA overexpression is a feature of human cancer and plays a causal role in cell transformation.
Esposito F, de Martino M, Petti MG, Forzati F, Tornincasa M, Federico A, Arra C, Pierantoni GM, Fusco A   +8 more
openaire   +6 more sources

Bioinformatics Analysis of circRNA Expression and Construction of “circRNA-miRNA-mRNA” Competing Endogenous RNAs Networks in Bipolar Disorder Patients

Frontiers in Genetics, 2021
Bipolar disorder (BD) is a severe mood disorder disease in China, and its underlying pathogenesis remains unknown. Circular RNAs (circRNAs) have been reported to play a key role in mental disorders and can be used as competitive endogenous RNAs (ceRNAs).
Yonghui Fu, Wenfeng He, Chaoxiong Zhou, Xia Fu, Qigen Wan, Ling He, Bo Wei   +6 more
doaj   +1 more source