Results 31 to 40 of about 110,378 (294)

Identification of lncRNA–miRNA–mRNA Networks Linked to Non-small Lung Cancer Resistance to Inhibitors of Epidermal Growth Factor Receptor

Frontiers in Genetics, 2021
Background: Tyrosine kinase inhibitors that act against epidermal growth factor receptor (EGFR) show strong efficacy against non-small cell lung cancer (NSCLC) involving mutated EGFRs.
Ting Wang, Chengliang Yang, Bing Li, Ying Xing, Jian Huang, Yangping Zhang, Shanshan Bu, Hong Ge   +7 more
doaj   +1 more source

Differentially-Expressed Pseudogenes in HIV-1 Infection. [PDF]

, 2015
Not all pseudogenes are transcriptionally silent as previously thought. Pseudogene transcripts, although not translated, contribute to the non-coding RNA pool of the cell that regulates the expression of other genes.
Adami, Christoph, Brown, C Titus, Gupta, Aditi, Zheng, Yong-Hui   +3 more
core   +2 more sources

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]

, 2012
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik, Altschul, Andrew C. Penn, Arzumanov, Arzumanov, Balik, Bass, Birney, Brusa, Carver, Daniel, Darty, Dominski, Egebjerg, Eisen, Enstero, Feldmeyer, Gallo, Ge, Greger, Hamada, Heasman, Higuchi, Higuchi, Hogg, Ingo H. Greger, Jepson, Jubin, Katoh, Kent, Kwak, Laurencikiene, Maas, Moulton, Peng, Reenan, Rice, Rosenthal, Rueter, Ryman, Schoft, Sommer, Stephens, Summerton, Summerton, Summerton, Tariq, Traynelis, Valente, Venkatesh, Yamashita, Yang   +51 more
core   +1 more source

Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

Life, 2021
Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack ...
Yubo Shi, Qingyun Huang, Xinyu Kong, Ruichen Zhao, Xinyue Chen, Yujia Zhai, Lixia Xiong   +6 more
doaj   +1 more source

A snoRNA modulates mRNA 3' end processing and regulates the expression of a subset of mRNAs. [PDF]

, 2017
mRNA 3' end processing is an essential step in gene expression. It is well established that canonical eukaryotic pre-mRNA 3' processing is carried out within a macromolecular machinery consisting of dozens of trans-acting proteins. However, it is unknown
Ding, Junjun, Guo, Yibin, Huang, Chunliu, Huang, Shanshan, Huang, Weijun, Huang, Xi, Jia, Jie, Ming, Siqi, Shi, Junjie, Shi, Yongsheng, Wu, Xingui, Xiang, Andy Peng, Yao, Chengguo, Zhang, Rui, Zhao, Wei   +14 more
core   +1 more source

Market Power and Technological Bias: The Case of Electricity Generation [PDF]

, 2006
It is difficult to elminated all market power in electricity markets and it is therefore frequently suggested that some market power should be tolerated: extra revenues contribute to fixed cost recovery,facilitate investment and increase security of ...
Neuhoff, Karsten, Twomey, Paul
core   +2 more sources

Identification of potential biomarkers of gout through competitive endogenous RNA network analysis

European Journal of Pharmaceutical Sciences, 2022
Gout is a widespread inflammatory arthritis. The present study aimed to identify potential biomarkers of gout and explore their underlying mechanisms through bioinformatics methods.The microarray data was downloaded from the GSE160170 dataset from the Gene Expression Omnibus (GEO) database, and the GEO2R online tool was used to obtain differentially ...
Yang, Li, Chengcheng, Huang, Zhenguo, Yang, Lei, Wang, Dan, Luo, Lu, Qi, Zhichao, Li, Yanqin, Huang   +7 more
openaire   +2 more sources

Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

BMC Medical Genomics, 2020
Background A growing evidence suggests that long non-coding RNAs (lncRNAs) can function as a microRNA (miRNA) sponge in various diseases including oral cancer. However, the pathophysiological function of lncRNAs remains unclear.
Junhao Yin, Xiaoli Zeng, Zexin Ai, Miao Yu, Yang’ou Wu, Shengjiao Li   +5 more
doaj   +1 more source

Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. [PDF]

, 2018
Deficiency of ribosomal proteins (RPs) leads to Diamond Blackfan Anemia (DBA) associated with anemia, congenital defects, and cancer. While p53 activation is responsible for many features of DBA, the role of immune system is less defined.
Bibikova, Elena, Danilova, Nadia, Lin, Shuo, Sakamoto, Kathleen M, Wilkes, Mark, Youn, Min-Young   +5 more
core   +2 more sources

BDNF Expression in Cortical GABAergic Interneurons [PDF]

, 2020
Brain-derived neurotrophic factor (BDNF) is a major neuronal growth factor that is widely expressed in the central nervous system. It is synthesized as a glycosylated precursor protein, (pro)BDNF and post-translationally converted to the mature form, (m ...
Barreda Tomás, Federico José, Heilmann, Heike, Münster-Wandowski, Agnieszka, Trimbuch, Thorsten, Turko, Paul, Vida, Imre, Yanagawa, Yuchio   +6 more
core   +1 more source