Results 31 to 40 of about 2,278,547 (269)

Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. [PDF]

Cell Cycle
Circular RNA (circRNA) can influence the development of hepatocellular carcinoma (HCC) as a competitive endogenous RNA (ceRNA). However, there are still many circRNAs whose functions are unknown. Our research explores the role of a novel circRNA, hsa_circ_0079875, in HCC.
Liu Y, Luo X, Chen W, Dong Z, Cheng T, Chen L, Ju L, Cai W, Bian Z.   +8 more
europepmc   +3 more sources

Competitive Endogenous RNAs Cannot Alter MicroRNA Function In Vivo [PDF]

Molecular Cell, 2014
In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).
Broderick, Jennifer A, Zamore, Phillip D.   +1 more
openaire   +3 more sources

Integrated Analysis of circRNA-miRNA-mRNA ceRNA Network in Cardiac Hypertrophy

Frontiers in Genetics, 2022
Cardiac hypertrophy is an adaptive cardiac response that accommodates the variable hemodynamic demands of the human body during extended periods of preload or afterload increase.
Yang-Hao Chen, Ling-Feng Zhong, Xia Hong, Qian-Li Zhu, Song-Jie Wang, Ji-Bo Han, Wei-Jian Huang, Bo-Zhi Ye   +7 more
doaj   +1 more source

The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo [PDF]

Cell, 2015
Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments demonstrated that pseudogenes contribute to cell transformation through several mechanisms. However, in vivo evidence for a causal role of pseudogenes in cancer development is lacking.
Karreth, Florian A, Reschke, Markus, Ruocco, Anna, Ng, Christopher, Chapuy, Bjoern, Léopold, Valentine, Sjoberg, Marcela, Keane, Thomas M, Verma, Akanksha, ALA, UGO, Tay, Yvonne, Wu, David, Seitzer, Nina, Velasco Herrera, Martin Del Castillo, Bothmer, Anne, Fung, Jacqueline, Langellotto, Fernanda, Rodig, Scott J, Elemento, Olivier, Shipp, Margaret A, Adams, David J, CHIARLE, Roberto, Pandolfi, Pier Paolo   +22 more
openaire   +3 more sources

Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors. [PDF]

Bioengineered, 2022
Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-coding RNA (lncRNA), and circular RNA (circRNA) etc. It is
Mao M, Zhang J, Xiang Y, Gong M, Deng Y, Ye D.   +5 more
europepmc   +3 more sources

Identification of lncRNA–miRNA–mRNA Networks Linked to Non-small Lung Cancer Resistance to Inhibitors of Epidermal Growth Factor Receptor

Frontiers in Genetics, 2021
Background: Tyrosine kinase inhibitors that act against epidermal growth factor receptor (EGFR) show strong efficacy against non-small cell lung cancer (NSCLC) involving mutated EGFRs.
Ting Wang, Chengliang Yang, Bing Li, Ying Xing, Jian Huang, Yangping Zhang, Shanshan Bu, Hong Ge   +7 more
doaj   +1 more source

Hsa_circ_0038383-mediated competitive endogenous RNA network in recurrent implantation failure

Aging, 2021
Inadequate endometrial receptivity contributes to recurrent implantation failure (RIF) during IVF-embryo transfer. Though multiple circRNAs have been confirmed differentially expression in RIF, the potential function of novel circRNAs needed to be detected.The top ten DEcircRNAs were selected as initial candidates.
Zhao, Huishan, Chen, Lili, Shan, Yinghua, Chen, Gang, Chu, Yongli, Dai, Huangguan, Liu, Xuemei, Bao, Hongchu   +7 more
openaire   +2 more sources

Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

BMC Medical Genomics, 2020
Background A growing evidence suggests that long non-coding RNAs (lncRNAs) can function as a microRNA (miRNA) sponge in various diseases including oral cancer. However, the pathophysiological function of lncRNAs remains unclear.
Junhao Yin, Xiaoli Zeng, Zexin Ai, Miao Yu, Yang’ou Wu, Shengjiao Li   +5 more
doaj   +1 more source

Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

Life, 2021
Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack ...
Yubo Shi, Qingyun Huang, Xinyu Kong, Ruichen Zhao, Xinyue Chen, Yujia Zhai, Lixia Xiong   +6 more
doaj   +1 more source

Introduction of LPIN1 as a potential diagnostic and prognostic biomarker for gastric cancer via integrative bioinformatics analysis of a competing endogenous RNA network and experimental validation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Identification of effective biomarkers is crucial for the heterogeneous disease of gastric cancer (GC). Recent studies have focused on the role of pseudogenes regulating gene expression through competing endogenous RNA (ceRNA) networks ...
Milad Daneshmand-Parsa, Parvaneh Nikpour
doaj   +1 more source