Results 31 to 40 of about 56,443 (240)

Construction and analysis of a lncRNA-miRNA-mRNA network based on competitive endogenous RNA reveal functional lncRNAs in oral cancer

BMC Medical Genomics, 2020
Background A growing evidence suggests that long non-coding RNAs (lncRNAs) can function as a microRNA (miRNA) sponge in various diseases including oral cancer. However, the pathophysiological function of lncRNAs remains unclear.
Junhao Yin, Xiaoli Zeng, Zexin Ai, Miao Yu, Yang’ou Wu, Shengjiao Li   +5 more
doaj   +1 more source

The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo [PDF]

Cell, 2015
Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments demonstrated that pseudogenes contribute to cell transformation through several mechanisms. However, in vivo evidence for a causal role of pseudogenes in cancer development is lacking.
Karreth, Florian A., Reschke, Markus, Ruocco, Anna, Ng, Christopher, Chapuy, Bjoern, Léopold, Valentine, Sjoberg, Marcela K., Keane, Thomas M., Verma, Akanksha, Ala, Ugo, Tay, Yvonne, Wu, David, Seitzer, Nina, Del Castillo Velasco-Herrera, Martín, Bothmer, Anne, Fung, Jacqueline, Langellotto, Fernanda, Rodig, Scott J., Elemento, Olivier, Shipp, Margaret A., Adams, David J., Chiarle, Roberto, Pandolfi, Pier Paolo   +22 more
openaire   +3 more sources

Regulatory mechanism of circular RNA involvement in osteoarthritis

Frontiers in Surgery, 2023
Osteoarthritis (OA) causes joint pain, stiffness, and dysfunction in middle-aged and older adults; however, its pathogenesis remains unclear. Circular RNAs (circRNAs) are differentially expressed in patients with OA and participate in a multigene ...
Yuke Zhang, Liting Liu, Kai Liu, Meiying Wang, Xiulan Su, Jianzhong Wang   +5 more
doaj   +1 more source

Introduction of LPIN1 as a potential diagnostic and prognostic biomarker for gastric cancer via integrative bioinformatics analysis of a competing endogenous RNA network and experimental validation [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Identification of effective biomarkers is crucial for the heterogeneous disease of gastric cancer (GC). Recent studies have focused on the role of pseudogenes regulating gene expression through competing endogenous RNA (ceRNA) networks ...
Milad Daneshmand-Parsa, Parvaneh Nikpour
doaj   +1 more source

Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis

Frontiers in Genetics, 2021
Severe acute pancreatitis (SAP) is an acute digestive system disease with high morbidity mortality and hospitalization rate worldwide, due to various causes and unknown pathogenesis.
Bing Wang, Bing Wang, Jun Wu, Jun Wu, Qilin Huang, Qilin Huang, Xiaohui Yuan, Xiaohui Yuan, Yi Yang, Yi Yang, Wen Jiang, Wen Jiang, Yi Wen, Lijun Tang, Lijun Tang, Hongyu Sun, Hongyu Sun, Hongyu Sun   +17 more
doaj   +1 more source

Comprehensive identification and characterization of lncRNAs and circRNAs reveal potential brown planthopper-responsive ceRNA networks in rice

Frontiers in Plant Science, 2023
Brown planthopper (Nilaparvata lugens Stål, BPH) is one of the most destructive pests of rice. Non-coding RNA plays an important regulatory role in various biological processes.
Yan Wu, Yan Wu, Wenjun Zha, Wenjun Zha, Dongfeng Qiu, Jianping Guo, Gang Liu, Changyan Li, Bian Wu, Sanhe Li, Junxiao Chen, Liang Hu, Shaojie Shi, Lei Zhou, Lei Zhou, Zaijun Zhang, Bo Du, Aiqing You, Aiqing You   +18 more
doaj   +1 more source

Kinetic Modelling of Competition and Depletion of Shared miRNAs by Competing Endogenous RNAs [PDF]

, 2019
Non-conding RNAs play a key role in the post-transcriptional regulation of mRNA translation and turnover in eukaryotes. miRNAs, in particular, interact with their target RNAs through protein-mediated, sequence-specific binding, giving rise to extended and highly heterogeneous miRNA-RNA interaction networks.
Martirosyan A, Del Giudice M, Bena CE, Pagnani A, Bosia C, De Martino A   +5 more
openaire   +4 more sources

Non‐coding RNA Identification in Osteonecrosis of the Femoral Head Using Competitive Endogenous RNA Network Analysis

Orthopaedic Surgery, 2021
Objective To investigate the regulatory network of long non‐coding RNA (lncRNA) as competing endogenous RNAs (ceRNAs) in osteonecrosis of the femoral head (ONFH).
Ning Han, Zengchun Li
doaj   +1 more source

Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma [PDF]

Medical Science Monitor, 2019
BACKGROUND Long non-coding RNAs (lncRNAs) affect post-transcriptional regulation by interfering with microRNAs (miRNAs), and by acting as competitive endogenous RNAs (ceRNAs). The roles and mechanisms of lncRNAs as ceRNAs in the progression and prognosis of uterine corpus endometrial carcinoma are not well understood.
Ouyang, Dong, Li, Ruyi, Li, Yaxian, Zhu, Xueqiong   +3 more
openaire   +2 more sources

Bioinformatics Analysis of circRNA Expression and Construction of “circRNA-miRNA-mRNA” Competing Endogenous RNAs Networks in Bipolar Disorder Patients

Frontiers in Genetics, 2021
Bipolar disorder (BD) is a severe mood disorder disease in China, and its underlying pathogenesis remains unknown. Circular RNAs (circRNAs) have been reported to play a key role in mental disorders and can be used as competitive endogenous RNAs (ceRNAs).
Yonghui Fu, Wenfeng He, Chaoxiong Zhou, Xia Fu, Qigen Wan, Ling He, Bo Wei   +6 more
doaj   +1 more source