The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis [PDF]
Scientific Reports, 2022 Osteoporosis (OP) is a common bone disease of old age resulting from the imbalance between bone resorption and bone formation. CircRNAs are a class of endogenous non-coding RNAs (ncRNAs) involved in gene regulation and may play important roles in the ...
Hao Li +5 more
doaj +5 more sources
Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke [PDF]
Frontiers in Genetics, 2022 Background: Acute ischemic stroke (AIS) is a severe neurological disease with complex pathophysiology, resulting in the disability and death. The goal of this study is to explore the underlying molecular mechanisms of AIS and search for new potential ...
Zongkai Wu +7 more
doaj +4 more sources
Construction, bioinformatics analysis, and validation of competitive endogenous RNA networks in ulcerative colitis [PDF]
Frontiers in Genetics, 2022 Background: Ulcerative colitis (UC) is a common chronic disease of the digestive system. Recently, competitive endogenous RNAs (ceRNAs) have been increasingly used to reveal key mechanisms for the pathogenesis and treatment of UC.
Longcong Dong +7 more
doaj +4 more sources
Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression. [PDF]
Cell CycleCircular RNA (circRNA) can influence the development of hepatocellular carcinoma (HCC) as a competitive endogenous RNA (ceRNA). However, there are still many circRNAs whose functions are unknown. Our research explores the role of a novel circRNA, hsa_circ_0079875, in HCC.
Liu Y +8 more
europepmc +3 more sources
Role of exosomal competitive endogenous RNA (ceRNA) in diagnosis and treatment of malignant tumors. [PDF]
Bioengineered, 2022 Malignant tumors are a threat to human health, thus it is critical to better understand the mechanism of tumor occurrence and development and to find key therapeutic targets. Competitive endogenous RNA (ceRNA) is a type of RNA molecule that includes mRNA of coding-protein, pseudogenes, long non-coding RNA (lncRNA), and circular RNA (circRNA) etc. It is
Mao M +5 more
europepmc +3 more sources
The Integrative Analysis of Competitive Endogenous RNA Regulatory Networks in Coronary Artery Disease [PDF]
Frontiers in Cardiovascular Medicine, 2021 Background: Coronary artery disease (CAD) is the leading cause of cardiovascular death. The competitive endogenous RNAs (ceRNAs) hypothesis is a new theory that explains the relationship between lncRNAs and miRNAs.
Yuyao Ji +7 more
doaj +3 more sources
Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer’s disease [PDF]
Neural Regeneration ResearchLong noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer’s disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated.
Li Zeng +7 more
doaj +2 more sources
Scientific Reports, 2021 To identify the prognostic biomarker of the competitive endogenous RNA (ceRNA) and explore the tumor infiltrating immune cells (TIICs) which might be the potential prognostic factors in lung adenocarcinoma.
Wenjie Chen +7 more
doaj +3 more sources
Establishment of potential lncRNA-related hub genes involved competitive endogenous RNA in lung adenocarcinoma [PDF]
BMC CancerLong non-coding RNAs (lncRNAs) have a notable role in the diagnosis and prognosis of cancer. However, the associations between lncRNA-related hub genes (LRHGs) expression and the corresponding outcomes have not been fully understood in lung ...
Yong Li +6 more
doaj +2 more sources
Long noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism [PDF]
Scientific ReportsOsteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis.
Zhouzhou Tang +5 more
doaj +2 more sources