Frontiers in Genetics, 2022 Keratoconus (KC) is the most common corneal ectatic disease, with its pathological mechanisms unclear. We mainly performed bioinformatics approaches to reveal core RNA targets and hub competitive endogenous RNA (ceRNA) network and explored the potential ...
Shuai Ouyang +5 more
doaj +3 more sources
DNA Double-Strand Break-Related Competitive Endogenous RNA Network of Noncoding RNA in Bovine Cumulus Cells. [PDF]
Genes (Basel), 2023 (1) Background: DNA double strand breaks (DSBs) are the most serious form of DNA damage that affects oocyte maturation and the physiological state of follicles and ovaries. Non-coding RNAs (ncRNAs) play a crucial role in DNA damage and repair. This study aims to analyze and establish the network of ncRNAs when DSB occurs and provide new ideas for next ...
Liu JB +13 more
europepmc +3 more sources
Long noncoding RNA GAS5 acts as a competitive endogenous RNA to regulate GSK-3β and PTEN expression by sponging miR-23b-3p in Alzheimer’s disease [PDF]
Neural Regeneration ResearchLong noncoding RNA and microRNA are regulatory noncoding RNAs that are implicated in Alzheimer’s disease, but the role of long noncoding RNA-associated competitive endogenous RNA has not been fully elucidated.
Li Zeng +7 more
doaj +2 more sources
Establishment of potential lncRNA-related hub genes involved competitive endogenous RNA in lung adenocarcinoma [PDF]
BMC CancerLong non-coding RNAs (lncRNAs) have a notable role in the diagnosis and prognosis of cancer. However, the associations between lncRNA-related hub genes (LRHGs) expression and the corresponding outcomes have not been fully understood in lung ...
Yong Li +6 more
doaj +2 more sources
Long noncoding RNA DHRS4 antisense RNA 1 suppresses osteosarcoma cell proliferation and promotes apoptosis through a competitive endogenous RNA mechanism [PDF]
Scientific ReportsOsteosarcoma (OS) is the most common primary malignant bone tumor. Recent evidence suggests that the novel long noncoding RNA DHRS4 antisense RNA 1 (DHRS4-AS1) serves an important role in cancer progression and metastasis.
Zhouzhou Tang +5 more
doaj +2 more sources
miR-34a regulates phenotypic modulation of vascular smooth muscle cells in intracranial aneurysm by targeting CXCR3 and MMP-2 [PDF]
Genetics and Molecular Biology, 2021 MicroRNAs (miRNAs) dysregulation is tightly related to diseases including tumor, neuro disease and cardiovascular disease. In this study, we investigated the potential biological effects of miR-34a and its target CXCR3 in phenotypic modulation of ...
Xuesong Yuan +5 more
doaj +1 more source
Advances on the roles of circular RNA in breast cancer [PDF]
Jichu yixue yu linchuang, 2022 Circular RNA (circRNA) is a kind of non-coding RNA with circular structure and is found in a variety of cell types. CircRNA is characterized by diversity, specificity, conservatism and stability.
HE Xiao, HU Wei-jie, LYU Wen-chang, REN Yu-ping, WU Min, WU Yi-ping, ZHANG Qi
doaj +1 more source
Comprehensive analysis of competitive endogenous RNA network in colorectal cancer [PDF]
Translational Cancer Research, 2020 Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Growing evidence supports a role for noncoding RNAs (ncRNAs) in CRC. In particular, they form competitive endogenous RNA (ceRNA) networks involved in the regulation of mRNA expression.
Zhang, Meng-Yi, Guo, Bin-Han
openaire +2 more sources
Integrated Analysis of ceRNA Network to Reveal Potential Prognostic Biomarkers for Glioblastoma
Frontiers in Genetics, 2022 Glioblastoma (GBM), originating in the brain, is a universally aggressive malignant tumor with a particularly poor prognosis. Therefore, insight into the critical role of underlying genetic mechanisms is essential to developing new therapeutic approaches.
Ruifei Liu +8 more
doaj +1 more source
Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma [PDF]
Bioengineered, 2021 Asthma is a chronic inflammatory disease characterized by airway remodeling and bronchial hyperresponsiveness. A variety of effector cells and cytokines jointly stimulate the occurrence of inflammatory response in asthma. Although the pathogenesis of asthma is not entirely clear, the possible roles of non-coding RNAs (ncRNAs) have been recently ...
Wang, Xiaoxu +6 more
openaire +2 more sources