Results 61 to 70 of about 110,378 (294)

Predicting functional circular RNA-based competitive endogenous RNA network in gastric carcinoma using novel bioinformatics analysis

Experimental Biology and Medicine, 2021
Gastric cancer (GC) remains one of the most prevalent types of malignancies worldwide, and also one of the most reported lethal tumor-related diseases. Circular RNAs (circRNAs) have been certified to be trapped in multiple aspects of GC pathogenesis. Yet, the mechanism of this regulation is mostly undefined.
Zirui Zhu, Rui Huang, Baojun Huang
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]

, 2015
FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J, Fan, R, Hou, Y, Hou, Y, Jiang, Y, Li, L, Li, W, Mittal, N, Peace, D, Qian, Z, Wang, X, Wu, W, Zhu, T   +12 more
core   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Comprehensive analysis of competitive endogenous RNA associated with immune infiltration in lung adenocarcinoma

Scientific Reports, 2021
To identify the prognostic biomarker of the competitive endogenous RNA (ceRNA) and explore the tumor infiltrating immune cells (TIICs) which might be the potential prognostic factors in lung adenocarcinoma.
Wenjie Chen, Wen Li, Zhenkun Liu, Guangzhi Ma, Yunfu Deng, Xiaogang Li, Zhu Wang, Qinghua zhou   +7 more
doaj   +1 more source

Comprehensive Analysis of Differentially Expressed lncRNAs miRNAs and mRNA and Their ceRNA Network of Patients With Rare-Earth Pneumoconiosis

Frontiers in Genetics, 2021
Rare-earth pneumoconiosis (REP) is the main occupational disease of rare earth exposed workers and there is no specific treatment. In this study, we performed high-throughput sequencing on the plasma of nine REP to describe and analyze the expression ...
Xue-min Shi, Yu-chao Bai, Yan-rong Gao, Ning Bu, Hai-yan Song, Li-hua Huang, Yu-hang Zhao, Su-hua Wang   +7 more
doaj   +1 more source

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal [PDF]

, 2013
Embryonic stem (ES) cell self-renewal efficiency is determined by the Nanog protein level. However, the protein partners of Nanog that function to direct self-renewal are unclear.
Alessia Gagliardi, Ambrosetti DC, Ambrosetti DC, Anastasia Felker, Anastasia I Kousa, Avilion AA, Bailey TL, Bogan AA, Brookes E, Chambers I, Chambers I, Chen X, Chen X, Costa Y, DeLano WL, Dignam JD, Douglas Colby, Engelen E, Favaro R, Festuccia N, Fidalgo M, Florian Halbritter, Gao Z, Genzor CG, Halbritter F, Han JD, Harley VR, Hatano SY, Ho SN, Hooper M, Hutchins AP, Ian Chambers, Jang H, Jason T Weiss, Jauch R, Jepsen K, Jeroen Demmers, Karel Bezstarosti, Kim J, Laemmli UK, Lam CS, Liang J, Ma T, Marson A, Maruyama M, Masui S, McDonel P, Mitsui K, Moretto-Zita M, Mullin NP, Navarro P, Navarro P, Nicholas P Mullin, Noble SM, Pardo M, Parisi S, Perkins DN, Qin J, Raymond A Poot, Rebecca Favaro, Remenyi A, Reynolds N, Rogers MS, Rugg-Gunn PJ, Shi W, Silvia K Nicolis, Simon R Tomlinson, Singh AM, Smith AG, Surface LE, Ura H, van den Berg DL, Wang J, Wang Z, Whyte WA, Wu Q, Yates A, Yuan H, Zappone MV, Zi Ying Tan   +79 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Target RNAs strike back on MicroRNAs [PDF]

, 2018
MicroRNAs are extensively studied regulatory non-coding small RNAs that silence animal genes throughout most biological processes, typically doing so by binding to partially complementary sequences within target RNAs.
de la Mata, Manuel, Fededa, Juan Pablo, Fuchs Wightman, Federico, Giono, Luciana Eugenia   +3 more
core   +1 more source

Comprehensive Analysis of Competitive Endogenous Rnas Network Associated With Hepatocellular Carcinoma [PDF]

, 2020
Abstract Background: Increasing evidences show that long non-coding RNA (lncRNA) plays the role of competitive endogenous RNAs (ceRNAs) in the development and progression of cancers. The purpose of our study was to identify potential lncRNA biomarkers that serve as a therapeutic target and prognostic biomarker in HCC.Methods: The differential ...
jiahui Wan, Xiuli Wang, Fusheng Zhao, Ying Jiang, Wei Ma, Shijun Jiang, Zikang He, Xiaojin Wang, Rongjun Cui   +8 more
openaire   +1 more source