Results 61 to 70 of about 2,278,547 (269)

Identification of potential biomarkers of gout through competitive endogenous RNA network analysis

European Journal of Pharmaceutical Sciences, 2022
Gout is a widespread inflammatory arthritis. The present study aimed to identify potential biomarkers of gout and explore their underlying mechanisms through bioinformatics methods.The microarray data was downloaded from the GSE160170 dataset from the Gene Expression Omnibus (GEO) database, and the GEO2R online tool was used to obtain differentially ...
Yang, Li, Chengcheng, Huang, Zhenguo, Yang, Lei, Wang, Dan, Luo, Lu, Qi, Zhichao, Li, Yanqin, Huang   +7 more
openaire   +2 more sources

Competing Endogenous RNA Networks Reveal Long Non-coding RNAs as Potential Prognostic Biomarkers in Gastric Cancer: A Systematic Review and Meta-Analysis

Advanced Biomedical Research
Background: Gastric cancer (GC) represents a global healthcare challenge. Recently, many competing endogenous RNA (ceRNA) network studies have elucidated critical long noncoding RNAs (lncRNAs) as potential prognostic biomarkers in GC.
Sadra Salehi-Mazandarani, Mohammad Hossein Donyavi, Amirhossein Vedaei, Alireza Najimi, Ziba Farajzadegan, Parvaneh Nikpour   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comprehensive Analysis of Differentially Expressed lncRNAs miRNAs and mRNA and Their ceRNA Network of Patients With Rare-Earth Pneumoconiosis

Frontiers in Genetics, 2021
Rare-earth pneumoconiosis (REP) is the main occupational disease of rare earth exposed workers and there is no specific treatment. In this study, we performed high-throughput sequencing on the plasma of nine REP to describe and analyze the expression ...
Xue-min Shi, Yu-chao Bai, Yan-rong Gao, Ning Bu, Hai-yan Song, Li-hua Huang, Yu-hang Zhao, Su-hua Wang   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Cancer Cell International, 2019
Background Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs in gastric cancer (GC) are still unknown.
Yong-jun Guan, Jian-ying Ma, Wei Song
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Roles of Cellular RNA-Dependent RNA Polymerases in Endogenous Small RNA Pathways in Caenorhabditis elegans: A Dissertation [PDF]

, 2010
The RNA interference (RNAi) pathway in Caenorhabditis elegans is a two-step, small RNA-mediated silencing pathway. Unlike in other organisms, Dicer processing of double-stranded RNA into small interfering (si) RNAs is not sufficient in worms to induce ...
Vasale, Jessica J.
core   +1 more source

Erratum: Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma.

Medical science monitor : international medical journal of experimental and clinical research, 2021
There was an error in Figure 4. The correct Figure 4 is provided below. The picture error would not affect the conclusion of the paper. Reference: Dong Ouyang, Ruyi Li, Yaxian Li, Xueqiong Zhu. Construction of a Competitive Endogenous RNA Network in Uterine Corpus Endometrial Carcinoma. Med Sci Monit 2019; 25:7998-8010. DOI: 10.12659/MSM.915798.
Ouyang, Dong, Li, Ruyi, Li, Yaxian, Zhu, Xueqiong   +3 more
openaire   +2 more sources

A Potential Competitive Endogenous RNA Pathway Involved in Chronic Spinal Cord Injury [PDF]

Medical Science Monitor, 2018
BACKGROUND Chronic spinal cord injury (CSCI) is a worldwide clinical problem. We aimed to reveal differentially expressed (DE) lncRNAs and to find associated pathways that may function as targets for CSCI therapy. MATERIAL AND METHODS After a CSCI rat model was confirmed by the Basso Beattie Bresnahan (BBB) scale and the Magnetic Resonance Imaging (MRI)
Zhang, Liang, Yang, Li, Li, Wenhui, Yang, Yalin, Sun, Weizong, Gong, Pengfei, Wang, Ling, Wang, Kai   +7 more
openaire   +2 more sources