Results 81 to 90 of about 2,278,547 (269)

CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression

Aging, 2019
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Recent years, circular RNA (circRNA) have been shown to exert vital functions in the pathological progressions of many diseases. A growing number of evidences have identified the representative function of exosomal circRNAs in the physiological state of donor cells, which ...
Su, Yang, Lv, Xiurui, Yin, Wei, Zhou, Lingling, Hu, Yilin, Zhou, Ang, Qi, FuZhen   +6 more
openaire   +2 more sources

Targeted Restoration of the Microbial Tryptophan Oxidative Pathway Ameliorates Autism‐Like Behavioral and Synaptic Deficits

Advanced Science, EarlyView.
ABSTRACT Autism Spectrum Disorder (ASD) is associated with gut microbiota dysbiosis, yet the contribution of specific microbial metabolic pathways remains unclear. Reanalysis of a public ASD cohort revealed reduced functional potential in microbial tryptophan oxidative metabolism.
Rui Guo, Caian He, Xiao Xiao, Jingmeng Li, Zilong Zhang, Ying He, Chuanchuan Wang, Jiale Zhao, Jun Gong, Jiarui Liang, Tian Yuan, Haiting Sun, Xuebo Liu, Chao Gao, Zhigang Liu   +14 more
wiley   +1 more source

Additional file 6: of Long non-coding RNA AGAP2-AS1, functioning as a competitive endogenous RNA, upregulates ANXA11 expression by sponging miR-16-5p and promotes proliferation and metastasis in hepatocellular carcinoma

, 2019
Figure S6. A schematic diagram representing the role of AGAP2-AS1, functioning as a competitive endogenous RNA.
Yufeng Wang, Zhikui Liu (3554570), Yufeng Wang (274657), Liang Wang, Yongshen Niu, Zhikui Liu, Liang Wang (23021), Tianxiang Chen (252805), Qingguang Liu, Liankang Sun, Bowen Yao (1835059), Yongshen Niu (6700727), Qingguang Liu (119654), Kangsheng Tu, Kangsheng Tu (428934), Liankang Sun (4269757), Tianxiang Chen, Runkun Liu, Runkun Liu (6700724), Bowen Yao   +19 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

RNA-specific ribonucleotidyl transferases [PDF]

, 2007
RNA-specific nucleotidyl transferases (rNTrs) are a diverse family of template-independent polymerases that add ribonucleotides to the 3'-ends of RNA molecules.
Keller, W., Martin, G., W. Keller, G. Martin, Martin G, Keller W   +5 more
core   +1 more source

Research Progress of Long Non-coding RNA in Esophageal Cancer

Zhongliu Fangzhi Yanjiu, 2018
With the technological innovation of molecular biology research and the vigorous development of computer bioinformatics, the role of long non-coding RNA(lncRNA) and its biological functions have been studied intensively.It plays important roles in ...
CHEN Mengxue, LI Xueliang
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Identification of a Circular RNA as a Potential Diagnostic and Prognostic Biomarker in Breast Cancer Through Integrated Bioinformatic and Experimental Analyses

Analytical Science Advances
Breast cancer (BC), which has complex molecular subgroups that contribute to a range of clinical outcomes, is still one of the top causes of morbidity and death among women globally. This challenge necessitates ongoing research to improve early detection,
MohamadReza Hashemi, Pejman Morovat, Azin Khoshghiafeh, Novin Nikbakhsh, Mohamadreza Ahmadifard   +4 more
doaj   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Identification of DGUOK-AS1 as a Prognostic Factor in Breast Cancer by Bioinformatics Analysis

Frontiers in Oncology, 2020
Background: Significant developments have been made in breast cancer diagnosis and treatment, yet the prognosis remains unsatisfactory. Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play pivotal roles in the development and ...
Yalun Li, Yalun Li, Yiran Liang, Tingting Ma, Qifeng Yang, Qifeng Yang   +5 more
doaj   +1 more source