Results 81 to 90 of about 110,378 (294)

Identification of a long non‑coding RNA‑mediated competitive endogenous RNA network in hepatocellular carcinoma

Oncology Reports, 2019
The present study was designed to identify the endogenous RNA regulatory networks involved in hepatocellular carcinoma (HCC) by bioinformatic analysis. Both miRNA interaction network‑based correlation analysis and expression‑based Spearman correlation coefficients were utilized to identify potential mRNA‑lncRNA interactions.
Hui, He, Di, Chen, Shimeng, Cui, Hailong, Piao, Haibo, Tang, Xun, Wang, Peng, Ye, Shi, Jin   +7 more
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Research Progress of Circular RNA CircHIPK3 in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer
Lung cancer ranks among the most prevalent and deadliest malignancies worldwide. Despite significant strides in targeted therapies and immunotherapy for lung cancer, curing the disease remains a highly prioritized issue.
Yuheng WANG, Liang CHEN
doaj   +1 more source

Identification of circRNA–miRNA–mRNA regulatory network in gastric cancer by analysis of microarray data

Cancer Cell International, 2019
Background Evidence is increasingly indicating that circular RNAs (circRNAs) are closely involved in tumorigenesis and cancer progression. However, the function of circRNAs in gastric cancer (GC) are still unknown.
Yong-jun Guan, Jian-ying Ma, Wei Song
doaj   +1 more source

Construction of Circular RNA–MicroRNA–Messenger RNA Regulatory Network of Recurrent Implantation Failure to Explore Its Potential Pathogenesis

Frontiers in Genetics, 2021
Background: Many studies on circular RNAs (circRNAs) have recently been published. However, the function of circRNAs in recurrent implantation failure (RIF) is unknown and remains to be explored.
Jiahuan Luo, Li Zhu, Li Zhu, Ning Zhou, Yuanyuan Zhang, Lirong Zhang, Lirong Zhang, Ruopeng Zhang, Ruopeng Zhang   +8 more
doaj   +1 more source

Negative spatial regulation of the lineage specific CyIIIa actin gene in the sea urchin embryo [PDF]

, 1990
The CyIIIa·CAT fusion gene was injected into Strongylocentrotus purpuratus eggs, together with excess ligated competitor sequences representing subregions of the CyIIIa regulatory domain.
Britten, Roy J., Davidson, Eric H., Franks, Roberta R., Hough-Evans, Barbara R., Zeller, Robert W.   +4 more
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

PVT1: a rising star among oncogenic long non-coding RNAs [PDF]

, 2015
It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function.
Colombo, Teresa, Farina, Lorenzo, Macino, Giuseppe, Paci, Paola   +3 more
core   +4 more sources

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

Molecular Medicine Reports, 2018
Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR.
Wu, Yingcheng, Jia, Keren, Wu, Huiqun, Sang, Aimin, Wang, Lei, Shi, Lili, Jiang, Kui, Dong, Jiancheng   +7 more
openaire   +3 more sources